Results 121 to 130 of about 46,600 (231)

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective

open access: yesLiver International, Volume 46, Issue 9, September 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga   +4 more
wiley   +1 more source

Tackling aging and chronic disease: How space exploration and the ‘chameleon effect’ of pharmaceuticals can lead the way

open access: yesExperimental Physiology, Volume 111, Issue 9, Page 4064-4072, 1 September 2026.
Abstract A common misconception surrounding space exploration is that humanity's pursuit of interplanetary travel, such as missions to Mars, is an escape from Earth. In reality, this endeavour offers an invaluable opportunity to address critical biomedical challenges here at home.
Carina Kern, Tina Woods, Keith Siew
wiley   +1 more source

Response to “Natural Coumarins as ABC Transporters Modulators: A Key Mechanistic Question for Osteosarcoma Chemotherapy”

open access: yes
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Parastoo Azadbeigi   +4 more
wiley   +1 more source

Molecular Mechanisms of Electric Signals Generated at Corneal Wounds

open access: yesThe FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Corneal injury triggers cell signaling (including calcium waves) leading to ion channel up‐regulation, increased ion pumping, and enhanced wound electric signals which stimulate wound healing. ABSTRACT Over 150 years ago, it was demonstrated that wounds produce electric fields and currents.
Brian Reid, Guillaume Luxardi, Min Zhao
wiley   +1 more source

Neuromuscular blocking action of verapamil in cats.

open access: yes, 1983
The effects of the calcium (slow) channel blocker verapamil, on non-cardiac excitable membranes were examined in vivo. In barbiturate anaesthetized cats, the effect of intravenously administered verapamil (0.1, 0.2, and 0.4 mg.kg-1) on isometric twitch ...
Gintautas, J, Lawson, N W, Kraynack, B J
core   +1 more source

Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458‐Based ST6GAL1 Inhibitors Enhance Membrane Permeability

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj   +9 more
wiley   +1 more source

Yavaş salinimli verapamil i?ntoksikasyonu

open access: yes, 2005
We observed toxicity in a patient who had taken high doses of slow-release verapamil. A 49 year-old female patient had ingested 25 tablets of verapamil (240 mg) with suicidal intentions. She presented with nausea and vomiting, hypotension, bradycardia. A
Özdemir Kol, Iclal   +4 more
core   +1 more source

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