Results 41 to 50 of about 1,721 (143)

Vericiguat, nuevo pilar en el tratamiento de la insuficiencia cardiaca con fracción de eyección reducida [PDF]

, 2023
Heart failure with reduced ejection fraction (HFrEF) is associated with high morbidity and mortality, conditioned by multiple hospitalizations. Vericiguat has currently beenshown to be effective and safe in patients with a recent decompensation.
Pérez-Ruiz, José M., Soria-Romero, Francisco Javier, Pérez-Velasco, Miguel Ángel, Pérez-Belmonte, Luis Miguel, Trenas, Alicia   +4 more
core   +1 more source

ANMCO position paper on vericiguat use in heart failure: from evidence to place in therapy [PDF]

, 2023
: In the growing therapeutic armamentarium for heart failure (HF) management, vericiguat represents an innovative therapeutic option. The biological target of this drug is different from that of other drugs for HF.
Di Fusco, Stefania Angela, Aquilani, Stefano, Gulizia, Michele Massimo, Manlio Cipriani, Oliva, Fabrizio, Michele Massimo Gulizia, Alberto Aimo, Aimo, Alberto, Andrea Matteucci, Navazio, Alessandro, Domenico Gabrielli, Leonardo De Luca, Alessandro Navazio, Stefano Aquilani, De Luca, Leonardo, Stefania Angela Di Fusco, Intravaia, Rita Cristina Myriam, Colivicchi, Furio, Alonzo, Alessandro, Valente, Serafina, Matteucci, Andrea, Rita Cristina Myriam Intravaia, Fabrizio Oliva, Serafina Valente, Alessandro Alonzo, Furio Colivicchi, Cipriani, Manlio, Gabrielli, Domenico   +27 more
core   +1 more source

Renal function and the effects of vericiguat in patients with worsening heart failure with reduced ejection fraction : insights from the VICTORIA (Vericiguat Global Study in Subjects with HFrEF) trial [PDF]

, 2021
Aims Vericiguat reduced the primary composite outcome of cardiovascular death or heart failure (HF) hospitalization in patients with worsening HF with reduced ejection fraction (HFrEF) and a lower limit of baseline estimated glomerular filtration rate ...
VICTORIA Study Grp, Voors, Adriaan A., Reyes, Eugene, Mulder, Hillary, Armstrong, Paul W., Lassus, Johan   +5 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano   +11 more
wiley   +1 more source

Vericiguat in Heart Failure: Characteristics, Scientific Evidence and Potential Clinical Applications

Biomedicines, 2022
Despite recent advances in heart failure (HF) management, the risk of death and hospitalizations remains high in the long term. HF is characterized by endothelial dysfunction, inflammation and increased oxidative stress, due to a reduction in the ...
Francesca Vannuccini, Alessandro Campora, Maria Barilli, Alberto Palazzuoli   +3 more
doaj   +1 more source

Initial Experience of Vericiguat Treatment in Patients with Heart Failure and Reduced Ejection Fraction

, 2023
Background: Vericiguat, a novel oral soluble guanylate cyclase stimulator, decreased the incidence of cardiovascular death and heart failure hospitalization in the cohort receiving triple therapy for heart failure with reduced ejection fraction. However,
Makiko Nakamura, Koichiro Kinugawa, Teruhiko Imamura   +2 more
core   +1 more source

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Vericiguat reduces atrial fibrillation recurrence by alleviating myocardial fibrosis via the TGF-β1/Smad2/3 pathway.

PLoS ONE
Atrial fibrillation (AF) and heart failure (HF) are mutually reinforcing, and the prognosis for both diseases is poor. Vericiguat is the first oral soluble guanylate cyclase (sGC) stimulator to be approved for the treatment of symptomatic, ejection ...
XiaoLin Sun, Yawen Sheng, Pei Xu, Qian Peng, Zhongbao Ruan   +4 more
doaj   +1 more source

2‐Chloro‐5‐(trifluoromethyl)aniline‐Derived Schiff Base Palladium(II) Complexes: From Molecular Design to Acute Toxicity Assessment

ChemistryOpen, Volume 15, Issue 10, October 2026.
Four new Schiff bases derived from 2‐chloro‐5‐(trifluoromethyl)aniline and their corresponding palladium(II) complexes were obtained and analyzed by multiple spectroscopic techniques. Single‐crystal X‐ray diffraction elucidated the structures of all the ligands and complexes 2 and 4. Their toxicity was assessed on Triticum aestivum L.
Andreea Elena Ştefan, Cristina Elena Dinu‐Pîrvu, Sergiu Shova, Ştefania Felicia Bărbuceanu, Teodora Venera Apostol, Diana Carolina Ilieş, Mihaela Badea, Mihaela Dinu, Robert Viorel Ancuceanu, Doina Drăgănescu, Elena Pahonţu   +10 more
wiley   +1 more source