Results 51 to 60 of about 1,721 (143)

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Additional file 1 of Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

, 2022
Additional file 1: Table S1. Vericiguat formulations administered within the clinical development program. Table S2. HPLC conditions for determination of vericiguat content in filtrate in dissolution studies. Table S3.
Wolfgang Mueck (223651), Michael Boettcher (120571), Maximilian Lobmeyer (14038275), Uwe Muenster (4385413), Corina Becker (6735149), Stephanie Loewen (14038272)   +5 more
core   +1 more source

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel, Andre Dallmann, Ibrahim Ince, Michaela Meyer, Jan‐Frederik Schlender, Donato Teutonico, Erik Sjögren   +6 more
wiley   +1 more source

Reversal of Pacing‐Induced Cardiomyopathy After Upgrade to Left Bundle Branch Area Pacing: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT High‐burden right ventricular pacing induced cardiomyopathy in a 47‐year‐old male; upgrading to left bundle branch area pacing may lead to rapid and sustained recovery of cardiac function.
Mengqi Yeh, Shunsong Chen, Shanshan He, Ke Liu, Kai Yang, Jiang Wang, Zhiying Zhao, Feiyan Shang, Jinrui Guo   +8 more
wiley   +1 more source

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, Volume 40, Issue 5, Page 2710-2729, May 2026.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

Vericiguat: A Novel Soluble Guanylate Cyclase Stimulator for Use in Patients With Heart Failure

, 2023
Heart failure (HF) affects 6.2 million Americans and is increasing annually in its frequency. Treatment of HF has been at the forefront of medical advancements due to the financial burden on our health care system.
Aronow, Wilbert S, Ahnert, Amy M, Vyas, Apurva V, Lanier, Gregg M, Frishman, William H, Wilbert S. Aronow, Maitz, Theresa, Theresa Maitz, Lin, Muling, Egeler, David J, Apurva V. Vyas, David J. Egeler, William H. Frishman, Sood, Aayaan, Gupta, Rahul, Muling Lin, Amy M. Ahnert, Rajeswaran, Yasotha, Aayaan Sood, Rahul Gupta, Yasotha Rajeswaran, Gregg M. Lanier   +21 more
core   +1 more source

Applicability of Vericiguat to Patients Hospitalized for Heart Failure in the United States. [PDF]

, 2023
BACKGROUND: In January 2021, vericiguat, a soluble guanylate cyclase stimulator, was approved by the U.S. Food and Drug Administration (FDA) to reduce the risk of cardiovascular death and heart failure (HF) hospitalization among patients with a recent ...
Fonarow, Gregg, Xu, Haolin, Hilkert, Robert, DeVore, Adam, Greene, Stephen, Alhanti, Brooke, Albert, Nancy, Butler, Javed, Allen, Larry, Lautsch, Dominik, Khan, Muhammad, Yancy, Clyde   +11 more
core   +1 more source

Vericiguat suppresses ventricular tachyarrhythmias inducibility in a rabbit myocardial infarction model.

PLoS ONE
BackgroundThe VICTORIA trial demonstrated a significant decrease in cardiovascular events through vericiguat therapy. This study aimed to assess the potential mechanisms responsible for the reduction of cardiovascular events with vericiguat therapy in a ...
Po-Cheng Chang, Hui-Ling Lee, Hung-Ta Wo, Hao-Tien Liu, Ming-Shien Wen, Chung-Chuan Chou   +5 more
doaj   +1 more source

Macrophage Cluster of Differentiation 163 promotes post‐infarction cardiac repair and preserves left ventricular function via osteopontin

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
• Circulating soluble CD163 is elevated in ischaemic cardiomyopathy and correlates with systolic dysfunction severity and ventricular dilation. • Macrophage CD163 protects against post‐infarction systolic dysfunction and left ventricular dilation in mice. • Loss of CD163 decreases macrophage osteopontin expression.
Jingyu Chen, Linjian Chen, Wei Huang, Gang Wang, Lin Wang, Wanchun Mei, Wei Ni, Yang Liu, Licheng Ding, Xiaofeng Ge, Zhaokai Li, Jing Yu, Shufen Huang, Jiayi Lin, Yifan Chen, Binni Cai, Peng Zhang, Cuilian Dai, Binbin Liu   +18 more
wiley   +1 more source

Open Systems Pharmacology Community Conference (OSP‐CC) Proceedings 2025

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Developed at Bayer Technology Services, PK‐Sim and MoBi transitioned into the Open Systems Pharmacology (OSP) Suite, released as free open‐source software in 2017. An active community with stakeholders from academia, industries, and regulators contributes to the continuous improvement of open‐source model‐informed drug development (MIDD). This
Henrik Cordes, Pieter Annaert, Pavel Balazki, Salih Benamara, Rodolfo Hernandes Bonan, Andrew Butler, Marylore Chenel, Yunhai Cui, André Dallmann, Wilhelmus E. A. de Witte, Cleo Demeester, Denise Feick, Florence Gattacceca, René Geci, Grégori Gerebtzoff, Andrea Gruber, Mariana Guimarães, Abdullah Hamadeh, Nina Hanke, Manuel Ibarra, Ibrahim Ince, Tobias Kanacher, Lars Kuepfer, Felix Mil, Ghazal Montaseri, Nina Nauwelaerts, Susana Proenca, Stephan Schaller, Jan Frederik Schlender, Annika R. P. Schneider, Erik Sjögren, Juri Solodenko, Alexander Staab, Paul Vrenken, Carla Troisi, Donato Teutonico   +35 more
wiley   +1 more source