Results 131 to 140 of about 271,842 (268)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Development and Verification of Test Procedures for Detecting Overloading and Improper Loading in Commercial Vehicles Using a High-Speed Weigh-in-Motion System: A Case Study in Republic of Korea

Applied Sciences
Despite continued efforts by the Korean government to improve road safety, truck-related accidents remain disproportionately fatal, with a rate approximately 2.6 times higher than that of passenger vehicles.
Ji-Won Jin, Chan-Woong Choi
doaj   +1 more source

Baseline evaluation of the impact of e-verification on counterfeit agricultural inputs and technology adoption in Uganda: Community listing exercise

, 2014
In Uganda, use of high-quality agricultural inputs like hybrid seed, agrochemicals, and fertilizer is extremely low. This depresses farm incomes and contributes to low agricultural productivity that continues to be hampered by poor agronomic practices ...
International Food Policy Research Institute (IFPRI)
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Abstract Interpretation-based verification/certification in the ciaoPP system

, 2005
CiaoPP is the abstract interpretation-based preprocessor of the Ciao multi-paradigm (Constraint) Logic Programming system. It uses modular, incremental abstract interpretation as a fundamental tool to obtain information about programs.
Albert Albiol, Elvira, Hermenegildo, Manuel V., Puebla Sánchez, Alvaro Germán   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Pregnancy and survival-related outcomes of uveal melanoma treated with brachytherapy in women of reproductive age

BMC Ophthalmology
Background To examine if pregnancy affects the prognosis of uveal melanoma (UM) patients undergoing plaque brachytherapy (PBT) and to assess if PBT has any subsequent impact on pregnancy outcomes.
Hao-Tian Wu, Li Dong, Rui-Heng Zhang, Wen-Da Zhou, He-Yan Li, Wen-Bin Wei, Yue-Ming Liu   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15‐year follow‐up study

Cancer Communications, 2022
Yu‐Ning Chen, Yi‐Ning Wang, Meng‐Xi Chen, Kai Zhang, Rong‐Tian Chen, Rui Fang, Heng Wang, Hai‐Han Zhang, Yi‐Ning Huang, Yu Feng, Jing‐Ting Luo, Yin‐Jun Lan, Yue‐Ming Liu, Yang Li, Wen‐Bin Wei   +14 more
doaj   +1 more source

Peripapillary RNFL cross-sectional area and its association with other parameters in a Chinese population

BMC Ophthalmology
Background Quantitative analysis of retinal nerve fibers is important for the diagnosis and treatment of optic nerve diseases. Peripapillary retinal nerve fiber layer (RNFL) cross-sectional area may give a more accurate quantitative assessment of retinal
Yan Yanni, Wang Qian, Wei Wenbin
doaj   +1 more source