Results 1 to 10 of about 6,456 (118)

Verteporfin-mediated on/off photoswitching functions synergistically to treat choroidal vascular diseases

Bioactive Materials, 2022
Choroidal vascular diseases, such as age-related macular degeneration, are the leading cause of vision impairment and are characterized by pathological angiogenesis.
Yahan Ju, Xiaochan Dai, Zhimin Tang, Zunzhen Ming, Ni Ni, Dongqing Zhu, Jing Zhang, Bo Ma, Jiajing Wang, Rui Huang, Siyu Zhao, Yan Pang, Ping Gu   +12 more
doaj   +1 more source

Transcatheter arterial chemoembolization combined with Hippo/YAP inhibition significantly improve the survival of rats with transplanted hepatocellular carcinoma

Lipids in Health and Disease, 2021
Background This study aimed to explore the effect of inhibiting the Hippo/Yes-associated protein (YAP) signaling pathway on the outcomes of transcatheter arterial chemoembolization (TACE) in treating transplanted hepatocellular carcinoma (HCC). Methods A
Yi Quan, Zhi Li, Kangshun Zhu, Jundi Liang   +3 more
doaj   +1 more source

Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin. [PDF]

PLoS ONE, 2014
Autophagy is a cellular catabolic process responsible for the degradation of cytoplasmic constituents, including organelles and long-lived proteins, that helps maintain cellular homeostasis and protect against various cellular stresses.
Elizabeth Donohue, Aruna D Balgi, Masaaki Komatsu, Michel Roberge   +3 more
doaj   +1 more source

Meta-analysis of best corrected visual acuity after treatment for myopic choroidal neovascularisation [PDF]

International Journal of Ophthalmology, 2014
AIM: To compare the best corrected visual acuity (BCVA) between Verteporfin with photodynamic therapy (PDT) and intravitreal anti-vascular endothelial growth factor (anti-VEGF) in patients with myopic choroidal neovascularization (CNV).METHOD: Published ...
Lin Zhou, Yi-Qiao Xing, Tuo Li, Yin Li, Xiu-Sheng Song, Jia-Zhang Li   +5 more
doaj   +1 more source

Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress

JCI Insight, 2021
Lung cancer with oncogenic KRAS makes up a significant proportion of lung cancers and is accompanied by a poor prognosis. Recent advances in understanding the molecular pathogenesis of lung cancer with oncogenic KRAS have enabled the development of drugs,
Iwao Shimomura, Naoaki Watanabe, Tomofumi Yamamoto, Minami Kumazaki, Yuji Tada, Koichiro Tatsumi, Takahiro Ochiya, Yusuke Yamamoto   +7 more
doaj   +1 more source

Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway

Frontiers in Oncology, 2020
Accumulated evidence has shown that the photosensitizer Verteporfin (VP) may be an ideal agent for various cancer types. However, the effect and mechanism of VP on human cervical carcinoma remain rudimentary.
Meng Wang, Chang Liu, Yuehan Li, Qiulin Zhang, Qiulin Zhang, Lixia Zhu, Zishui Fang, Lei Jin   +7 more
doaj   +1 more source

Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade

Veterinary Quarterly, 2021
The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus.
Shaydee J. Budel, Marloes M. Penning, Louis C. Penning   +2 more
doaj   +1 more source

The impact of interaction between verteporfin and yes-associated protein 1/transcriptional coactivator with PDZ-binding motif-TEA domain pathway on the progression of isocitrate dehydrogenase wild-type glioblastoma

Journal of Central Nervous System Disease, 2023
Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM).
Mahmoud Osama MD, Muhammed Amir Essibayi MD, Mona Osama B Pharm, Ismail A. Ibrahim, Mostafa Nasr Mostafa MD, Murat Şakir Ekşi MD   +5 more
doaj   +1 more source

Verteporfin: A Novel Antiproliferative Agent for Urinary Tract Fibrosis?

Société Internationale d’Urologie Journal, 2022
None available.
Jas Singh
doaj   +1 more source

Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused by Trp53 and Rb1 Deficiency in Ctsk-Expressing Cells via Impeding Hippo Pathway

Cells, 2022
Osteosarcoma is the most common primary malignancy of bone in children and adolescents. Others and our previous studies have shown that Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) as core components of the Hippo ...
Yang Li, Shuting Yang, Shuying Yang
doaj   +1 more source