Results 11 to 20 of about 6,525 (155)

GPSM2 Promotes Pancreatic Cancer Progression Through METTL3-Mediated m6A Modification of YAP1 mRNA. [PDF]

J Cell Mol Med
ABSTRACT Pancreatic cancer poses a major therapeutic challenge due to its insidious onset and difficulty in early diagnosis. G‐protein signalling modulator 2 (GPSM2), a member of the G‐protein signalling regulator family, is highly expressed in various tumour tissues; however, its role in pancreatic cancer remains largely undefined.
Xiu J, Qiao L, Li M, Hu X, Shen Z, Yang R, Zhang H, Dong Z, Liu X, Zhang Y.   +9 more
europepmc   +2 more sources

Airborne ¹O₂ Delivery via a Superhydrophobic Dressing as a Pathway to Next-Generation Wound Therapies, an In Vivo Murine Burn Model Study. [PDF]

Adv Healthc Mater
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Cabral FV, Xu Q, Eidenschink N, Haresh P, Rastelli ANS, Goverman J, Greer A, Lyons AM, Hasan T.   +8 more
europepmc   +2 more sources

Comparison between the functional and anatomical outcomes of full-dose, half-dose photodynamic therapy and intravitreal bevacizumab in chronic central serous chorioretinopathy

Journal of the Egyptian Ophthalmological Society, 2015
Purpose The aim of the present study was to compare the efficacy of full-dose, half-dose photodynamic therapy (PDT) and intravitreal bevacizumab (IVB) injection in treatment of chronic central serous chorioretinopathy (CCSC). Design The current study was
Abdelrahman G Salman
doaj   +1 more source

Evaluation of Verteporfin as a Novel Antifibrotic Agent in a Rabbit Model of Glaucoma Filtration Surgery

Ophthalmology Science
Purpose: Verteporfin is a benzoporphyrin derivative which is Food and Drug Administration-approved for treatment of choroidal neovascularization in conjunction with photodynamic therapy. It has been shown to prevent fibrosis and scar formation in several
Michelle T. Sun, MBBS, PhD, Renee M. Cotton, VMD, Chaow Charoenkijkajorn, MD, Julian Garcia-Sanchez, MD, Roopa Dalal, MSc, Xin Xia, MD, PhD, Jonathan H. Lin, MD, PhD, Kuldev Singh, MD, Jeffrey L. Goldberg, MD, PhD, Wendy W. Liu, MD, PhD   +9 more
doaj   +1 more source

Combination of verteporfin-photodynamic therapy with 5-aza-2’-deoxycytidine enhances the anti-tumour immune response in triple negative breast cancer

Frontiers in Immunology, 2023
IntroductionTriple negative breast cancer (TNBC) is a subtype of breast cancer characterised by its high tumourigenic, invasive, and immunosuppressive nature.
Shramana M. Banerjee, Shramana M. Banerjee, Pilar Acedo, Pilar Acedo, Soha El Sheikh, Rania Harati, Amelia Meecham, Norman R. Williams, Gareth Gerard, Mohammed R. S. Keshtgar, Mohammed R. S. Keshtgar, Alexander J. MacRobert, Rifat Hamoudi, Rifat Hamoudi   +13 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Real-world data of verteporfin-related ocular adverse events: A disproportionality analysis

Photodiagnosis and Photodynamic Therapy
Aim/Background: To investigate verteporfin-induced ocular adverse events (AEs) by analysing real-world data reported in the US Food and Drug Administration's Adverse Event Reporting System (FAERS) database.
Nesrin Caglayan Duman, Aslihan Uzun
doaj   +1 more source

Photoproducts of the Photodynamic Therapy Agent Verteporfin Identified via Laser Interfaced Mass Spectrometry

Molecules, 2020
Verteporfin, a free base benzoporphyrin derivative monoacid ring A, is a photosensitizing drug for photodynamic therapy (PDT) used in the treatment of the wet form of macular degeneration and activated by red light of 689 nm.
Chris Furlan, Jacob A. Berenbeim, Caroline E. H. Dessent   +2 more
doaj   +1 more source

Inhibiting YAP in Endothelial Cells From Entering the Nucleus Attenuates Blood-Brain Barrier Damage During Ischemia-Reperfusion Injury

Frontiers in Pharmacology, 2021
Blood-brain barrier (BBB) damage is a critical event in ischemic stroke, contributing to aggravated brain damage. Endothelial cell form a major component of the BBB, but its regulation in stroke has yet to be clarified.
Shuaishuai Gong, Huifen Ma, Fan Zheng, Juan Huang, Yuanyuan Zhang, Boyang Yu, Fang Li, Junping Kou   +7 more
doaj   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source