Results 151 to 160 of about 142,528 (291)

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins. [PDF]

Metabolites, 2022
Sarin HV, Hulmi JJ, Qin Y, Inouye M, Ritchie SC, Cheng S, Watrous JD, Nguyen TC, Lee JH, Jin Z, Terwilliger JD, Niiranen T, Havulinna A, Salomaa V, Pietiläinen KH, Isola V, Ahtiainen JP, Häkkinen K, Jain M, Perola M.   +19 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Glycosphingolipids with Very Long-Chain Fatty Acids Accumulate in Fibroblasts from Adrenoleukodystrophy Patients. [PDF]

Int J Mol Sci, 2021
Fujiwara Y, Hama K, Shimozawa N, Yokoyama K.   +3 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent US 2011/0189697 A1) [PDF]

, 2011
The present disclosure is relative to a method for the production of Very-Long-Chain Fatty Acids (VLCFA) into a plant cell, including culturing a recombinant plant cell in an appropriate medium, wherein said plant cell is transformed with an heterologous
Faure, J-D., Napier, J. A., Miquel, M., Bach, L.   +3 more
core  

False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. [PDF]

J Pediatr Endocrinol Metab, 2021
Zhu J, Breault DT.
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Recombinant Cells And Plants For Synthesis Of Very Long Chains Fatty Acid (vlcfa) (Patent WO 2009/156469 A1) [PDF]

, 2009
The present invention is relative to a method for the production of Very-Long-Chain Fatty Acids (VLCFA) into a plant cell, comprising culturing a recombinant plant cell in an appropriate medium, wherein said plant cell is transformed with an heterologous
Faure, J-D., Napier, J. A., Miquel, M., Bach, L.   +3 more
core  

Association between the circulating very long-chain saturated fatty acid and cognitive function in older adults: findings from the NHANES

BMC Public Health
Background Age-related cognitive decline has a significant impact on the health and longevity of older adults. Circulating very long-chain saturated fatty acids (VLSFAs) may actively contribute to the improvement of cognitive function.
Yanxin Shen, Chunxiao Wei, Yezi Taishi, Guimei Zhang, Zhan Su, Panpan Zhao, Yongchun Wang, Mingxi Li, Yingshi Ji, Li Sun   +9 more
doaj   +1 more source