Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species[S] [PDF]
Journal of Lipid Research, 2010 Enhanced production of monounsaturated fatty acids (FA) derived from carbohydrate-enriched diets has been implicated in the development of obesity and insulin resistance.
Christopher D. Green +4 more
doaj +8 more sources
Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men [PDF]
Brain Sciences, 2022 One line of research on the possible ways of inhibiting the growth of glioblastoma multiforme (GBM), a brain tumor with a very poor prognosis, is the analysis of its metabolism, such as fatty acid synthesis by desaturases and elongases.
Jan Korbecki +7 more
doaj +3 more sources
Mammalian fatty acid elongases. [PDF]
Methods Mol Biol, 2009 Summary Very long chain fatty acids confer functional diversity on cells by variations in their chain length and degree of unsaturation. Microsomal fatty acid elongation represents the major pathway for determining the chain length of saturated ...
Jump DB.
europepmc +5 more sources
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases [PDF]
Journal of Lipid Research, 2005 Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult ...
Yun Wang +5 more
doaj +4 more sources
Engineering yeast for tailored fatty acid profiles [PDF]
Applied Microbiology and BiotechnologyThe demand for sustainable and eco-friendly alternatives to fossil and plant oil-derived chemicals has spurred interest in microbial production of lipids, particularly triacylglycerols, fatty acids, and their derivatives.
Simon Kobalter +2 more
doaj +3 more sources
Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis
Journal of Lipid Research, 2004 In algae, the biosynthesis of docosahexaenoic acid (22:6ω3; DHA) proceeds via the elongation of eicosapentaenoic acid (20:5ω3; EPA) to 22:5ω3, which is required as a substrate for the final Δ4 desaturation. To isolate the elongase specific for this step,
Astrid Meyer +11 more
doaj +4 more sources
A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology. [PDF]
Eur J Med Res, 2023 Background The very-long-chain fatty acid elongase (ELOVL) family plays essential roles in lipid metabolism and cellular functions. This comprehensive review explores the structural characteristics, functional properties, and physiological significance ...
Wang X, Yu H, Gao R, Liu M, Xie W.
europepmc +2 more sources
The structural basis of fatty acid elongation by the ELOVL elongases [PDF]
Nature Structural & Molecular Biology, 2020 Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalyzed by the 3-keto acyl-coenzyme A (CoA) synthases (in mammals, ELOVL elongases)
Laiyin Nie +15 more
semanticscholar +7 more sources
Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction. [PDF]
Eur J Clin Nutr, 2012 Aslibekyan S +8 more
europepmc +3 more sources
Functional characterization of the chicken fatty acid elongases. [PDF]
The Journal of Nutrition, 2013 The health benefits of the (n-3) PUFA, EPA, and DHA have created a demand for fish and fish oil, the main sources of these PUFA. Production animals, such as poultry, are potential alternate and sustainable sources of EPA and DHA, provided these fatty acids can be synthesized from plant-derived α-linolenic acid [ALA, 18:3(n-3)].
M. Gregory +3 more
semanticscholar +4 more sources