Results 21 to 30 of about 633,143 (229)

Functional Characterization of Two Elongases of Very Long-Chain Fatty Acid from Tenebrio molitor L. (Coleoptera: Tenebrionidae) [PDF]

Scientific Reports, 2017
The elongases of very long chain fatty acid (ELOVL or ELO) are essential in the biosynthesis of fatty acids longer than C14. Here, two ELO full-length cDNAs (TmELO1, TmELO2) from the yellow mealworm (Tenebrio molitor L.) were isolated and the functions ...
Tianxiang Zheng, Hongshuang Li, Na Han, Shengyin Wang, J. Hackney Price, Minzi Wang, Dayu Zhang   +6 more
semanticscholar   +3 more sources

The repertoire of desaturases and elongases reveals fatty acid variations in 56 eukaryotic genomes [PDF]

Journal of Lipid Research, 2008
The repertoire of biosynthetic enzymes found in an organism is an important clue for elucidating the chemical structural variations of various compounds. In the case of fatty acids, it is essential to examine key enzymes that are desaturases and elongases, whose combination determine the range of fatty acid structures. We systematically investigated 56
Kosuke Hashimoto, Akiyasu C Yoshizawa, Shujiro Okuda   +2 more
exaly   +4 more sources

Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity [PDF]

Journal of Lipid Research, 2006
Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid composition. We examined the role that key transcription factors played in the control of hepatic elongase and desaturase expression.
Yun Wang, Daniela Botolin, Jinghua Xu, Barbara Christian, Ernestine Mitchell, Bolleddula Jayaprakasam, Muraleedharan Nair, Jeffery M. Peters, Julia Busik, L. Karl Olson, Donald B. Jump   +10 more
doaj   +3 more sources

Freshwater-adapted polychaetes exhibit a complete enzymatic machinery for synthesizing long-chain polyunsaturated fatty acids [PDF]

Open Biology
The sustainability of aquaculture is challenged by limited fishmeal and fish oil supplies, key sources of long-chain polyunsaturated fatty acids (LC-PUFA) such as eicosapentaenoic acid (EPA, 20:5 n-3), docosahexaenoic acid (DHA, 22:6 n-3) and arachidonic
Khalida Bainour, Nabilah Zulkifli, Ka-Kei Sam, Juan C. Navarro, Luis Filipe C. Castro, Christopher J. Glasby, Alexander C. Shu-Chien, Óscar Monroig   +7 more
doaj   +2 more sources

Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease [PDF]

Journal of Clinical Medicine, 2022
Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between ...
J. Martínez-Sanz, M. Calvo, S. Serrano-Villar, M. Montes, R. Martín-Mateos, D. Burgos‐Santamaría, J. Díaz-Álvarez, Alba Talavera-Rodríguez, M. Rosas, S. Moreno, J. Fontecha, M. Sánchez-Conde   +11 more
semanticscholar   +2 more sources

Polyketide synthase-like functionality acquired by plant fatty acid elongase. [PDF]

Sci Adv
Abstract Fatty acid elongation (FAE) typically proceeds through a four-step cycle of condensation, reduction, dehydration, and reduction to yield very long-chain fatty acids. Here, we describe a variation of this pathway in Orychophragmus limprichtianus , whose seed oil was found to
Kim H, Park K, Jia H, Huang F, Tang X, Zhong T, Yu W, Riethoven JM, Cahoon RE, Zhang C, Cahoon EB.   +10 more
europepmc   +3 more sources

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer [PDF]

Cancer Research, 2021
Abstract The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation of novel AR targeting therapies, outcomes for metastatic disease remain dismal. There is an urgent need to better understand androgen-regulated cellular processes to more effectively ...
Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler   +32 more
openaire   +7 more sources

Expression of fatty acid elongases in cells of the seminiferous epithelium

, 2014
Fil: Oresti, Gerardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Oresti, Gerardo Martín, Furland, Natalia Edith, Vasquez, C., Osses, N., Reyes, J. G., Aveldaño, Marta Isabel   +5 more
openaire   +2 more sources

Molecular characterization of biosynthesis of polyunsaturated fatty acids during different developmental stages in the copepod Apocyclops royi

Aquaculture Reports, 2022
Copepod Apocyclops royi can biosynthesize long-chain polyunsaturated fatty acids (LC-PUFAs) when fed low-PUFA precursors. Previously, two elongases and two desaturases in the n-3 PUFA biosynthetic pathway were identified from A. royi.
Piti Amparyup, Supakarn Sungkaew, Walaiporn Charoensapsri, Paveena Tapaneeyaworawong, Parichat Chumtong, Patchari Yocawibun, Prarthana Pantong, Ratree Wongpanya, Chanprapa Imjongjirak, Sorawit Powtongsook   +9 more
doaj   +1 more source

Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides

Proceedings of the National Academy of Sciences of the United States of America, 2004
Sandra Trenkamp, William F Martin, Trenkamp Sandra   +2 more
exaly   +2 more sources