Results 1 to 10 of about 84,621 (282)

The HMG-box protein PtHMG1 modulates lipid accumulation and fatty acid composition in the diatom Phaeodactylum tricornutum [PDF]

Frontiers in Plant Science
IntroductionThe diatom Phaeodactylum tricornutum is a premier biological platform for producing high-value polyunsaturated fatty acids (PUFAs). However, the transcriptional mechanisms coordinating lipid accumulation and fatty acid composition remain ...
Yuanfeng Li, Yuanfeng Li, Ning Ma, Ning Ma, Pu Song, Pu Song, Shaokun Dong, Shaokun Dong, Ronglu Liu, Ronglu Liu, Youyi Zhou, Youyi Zhou, Hongjin Qiao, Hongjin Qiao   +13 more
doaj   +2 more sources

Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity

Frontiers in Nutrition, 2023
IntroductionFatty acids (FAs) composition and desaturase activities can be altered in different metabolic conditions, but the adiposity-independent associations with clinical and biochemical indicators of cardiometabolic risk are still unclear.
Ivana Šarac, Jasmina Debeljak-Martačić, Marija Takić, Vuk Stevanović, Jelena Milešević, Milica Zeković, Tamara Popović, Jovica Jovanović, Nevena Kardum Vidović   +8 more
doaj   +1 more source

Biosynthesis of Fatty Acid Derivatives by Recombinant Yarrowia lipolytica Containing MsexD2 and MsexD3 Desaturase Genes from Manduca sexta

Journal of Fungi, 2023
One of the most interesting groups of fatty acid derivates is the group of conjugated fatty acids from which the most researched include: conjugated linoleic acid (CLA) and conjugated linolenic acid (CLNA), which are associated with countless health ...
Jaroslav Hambalko, Peter Gajdoš, Jean-Marc Nicaud, Rodrigo Ledesma-Amaro, Michal Tupec, Iva Pichová, Milan Čertík   +6 more
doaj   +1 more source

Acyl-Lipid Δ⁶-Desaturase May Act as a First FAD in Cyanobacteria

Biomolecules, 2022
Fatty acid desaturases (FADs) play important roles in various metabolic and adaptive pathways in all living organisms. They represent a superfamily of oxygenases that introduce double bonds into the acyl chains of fatty acids (FAs).
Alexander Y. Starikov, Roman A. Sidorov, Sergei V. Goriainov, Dmitry A. Los   +3 more
doaj   +1 more source

Different Cis-Regulatory Elements Control the Tissue-Specific Contribution of Plastid ω-3 Desaturases to Wounding and Hormone Responses

Frontiers in Plant Science, 2021
Trienoic fatty acids are essential constituents of biomembranes and precursors of jasmonates involved in plant defense responses. Two ω-3 desaturases, AtFAD7 and AtFAD8, synthetize trienoic fatty acids in the plastid.
María A. Luján, Ángel Soria-García, Ana Claver, Patricia Lorente, María C. Rubio, Rafael Picorel, Miguel Alfonso   +6 more
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Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis

Frontiers in Nutrition, 2022
Dietary bioactive lipids, one of the three primary nutrients, is not only essential for growth and provides nutrients and energy for life's activities but can also help to guard against disease, such as Alzheimer's and cardiovascular diseases, which ...
Xiao-Yan Zhuang, Yong-Hui Zhang, An-Feng Xiao, Ai-Hui Zhang, Bai-Shan Fang, Bai-Shan Fang   +5 more
doaj   +1 more source

Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study

Biomolecules, 2021
Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome.
Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, Jerome Baudry   +4 more
doaj   +1 more source

Light-Stress Response Mediated by the Transcription Factor KlMga2 in the Yeast Kluyveromyces lactis

Frontiers in Microbiology, 2021
In unicellular organisms like yeasts, which do not have specialized tissues for protection against environmental challenges, the presence of cellular mechanisms to respond and adapt to stress conditions is fundamental.
Ilaria Camponeschi, Arianna Montanari, Marzia Beccaccioli, Massimo Reverberi, Cristina Mazzoni, Michele M. Bianchi   +5 more
doaj   +1 more source

Temperature Acclimation of the Picoalga Ostreococcus tauri Triggers Early Fatty-Acid Variations and Involves a Plastidial ω3-Desaturase

Frontiers in Plant Science, 2021
Alteration of fatty-acid unsaturation is a universal response to temperature changes. Marine microalgae display the largest diversity of polyunsaturated fatty-acid (PUFA) whose content notably varies according to temperature.
Charlotte Degraeve-Guilbault, Nattiwong Pankasem, Maurean Gueirrero, Cécile Lemoigne, Frédéric Domergue, Tomonori Kotajima, Iwane Suzuki, Jérôme Joubès, Florence Corellou   +8 more
doaj   +1 more source

Molecular basis for differential elongation of omega-3 docosapentaenoic acid by the rat Elovl5 and Elovl2[S]

Journal of Lipid Research, 2013
Functional characterization of the rat elongases, Elovl5 and Elovl2, has identified that Elovl2 is crucial for omega-3 docosahexaenoic acid (DHA) (22:6n-3) synthesis.
Melissa K. Gregory, Leslie G. Cleland, Michael J. James   +2 more
doaj   +1 more source