Results 31 to 40 of about 80,074 (304)

The Partitioning of Newly Assimilated Linoleic and α-Linolenic Acids Between Synthesis of Longer-Chain Polyunsaturated Fatty Acids and Hydroxyoctadecaenoic Acids Is a Putative Branch Point in T-Cell Essential Fatty Acid Metabolism

Frontiers in Immunology, 2021
Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used stable
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge   +8 more
doaj   +1 more source

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells [PDF]

, 2013
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined.
Wei, Yijuan, Hu, Bingfang, Wen Xie, Xie Wen, Zhai Yonggong, Yonggong Zhai, Huang Min, Bingfang Hu, Hu, B, Xie, W, Jun Zhang, Yijuan Wei, Zhai, Yonggong, Xie, Wen, Min Huang, Zhang Jun, Hu Bingfang, Huang, M, Huang, Min, Wei Yijuan, Zhang, Jun, Zhang, J, Wei, Y, Zhai, Y   +23 more
core   +1 more source

FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases [PDF]

, 2009
Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease.
Lattka, E., Lattka, Eva, Heinrich, Joachim, Illig, T., Koletzko, Berthold, Heinrich, J., Illig, Thomas, Koletzko, B.   +7 more
core   +1 more source

Stearoyl-CoA desaturase and tumorigenesis

Chemico-Biological Interactions, 2020
Stearoyl-CoA desaturase (SCD) generates monounsaturated fatty acids (MUFAs) which contribute to cell growth, survival, differentiation, metabolic regulation and signal transduction. Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease.
Kohtaro, Kikuchi, Hidekazu, Tsukamoto
openaire   +3 more sources

Fatty acid desaturase 2 promoter mutation is not responsible for Δ6-desaturase deficiency [PDF]

European Journal of Human Genetics, 2011
Dietary essential polyunsaturated fatty acids (PUFAs) require fatty acid desaturases (FADS) for conversion to long-chain PUFAs (LCPUFAs), which are critical for many aspects of human health. A Δ6-desaturase deficiency in a single patient was attributed to an insertion mutation in the FADS2 promoter.
Melissa K, Gregory, Susan E, Lester, Rebecca J, Cook-Johnson, Robert A, Gibson, Susanna M, Proudman, Leslie G, Cleland, Michael J, James   +6 more
openaire   +2 more sources

Transformation and Characterization of Δ12-Fatty Acid Acetylenase and Δ12-Oleate Desaturase Potentially Involved in the Polyacetylene Biosynthetic Pathway from Bidens pilosa

Plants, 2020
Bidens pilosa is commonly used as an herbal tea component or traditional medicine for treating several diseases, including diabetes. Polyacetylenes have two or more carbon–carbon triple bonds or alkynyl functional groups and are mainly derived from fatty
Po-Yen Chen, Mi-Jou Hsieh, Yung-Ting Tsai, Hsiao-Hang Chung, Lie-Fen Shyur, Cheng-Han Hsieh, Kin-Ying To   +6 more
doaj   +1 more source

Desaturase Genes Expression and Fatty Acid Composition of Pleurotus ostreatus in Response to Zinc and Iron [PDF]

Journal of Cell and Molecular Research, 2018
The influence of ZnSO4, FeSO4, ZnO, and Fe2O3 at 80 µM on the expression of desaturase genes and fatty acid composition of Pleurotus ostreatus was investigated. Fatty acid was extracted by lipid extraction and methylation procedure using acidic methanol:
Kamran Safavi, Gholamreza Kavoosi, Roghayeh Siahbalaei   +2 more
doaj   +1 more source

Molecular basis for differential elongation of omega-3 docosapentaenoic acid by the rat Elovl5 and Elovl2[S]

Journal of Lipid Research, 2013
Functional characterization of the rat elongases, Elovl5 and Elovl2, has identified that Elovl2 is crucial for omega-3 docosahexaenoic acid (DHA) (22:6n-3) synthesis.
Melissa K. Gregory, Leslie G. Cleland, Michael J. James   +2 more
doaj   +1 more source

Functional Analysis of the C-5 Sterol Desaturase PcErg3 in the Sterol Auxotrophic Oomycete Pathogen Phytophthora capsici

Frontiers in Microbiology, 2022
Although sterols play an important role in most eukaryotes, some oomycetes, including Phytophthora spp., have lost the sterol synthesis pathway. Nevertheless, the ERG3 gene encoding C-5 sterol desaturase in the sterol synthesis pathway is still present ...
Weizhen Wang, Tongshan Cui, Fan Zhang, Zhaolin Xue, Borui Zhang, Xili Liu, Xili Liu   +6 more
doaj   +1 more source

Les lipides des différentes catégories de pépins de Cabernet Sauvignon au moment de la véraison

OENO One, 1980
Cinq catégories de pépins de Cabernet Sauvignon ont été séparées à la véraison. Plus de 95 p. 100 des acides gras sont contenus dans les lipides neutres.
J. J. Lavaud, Monique Cherrad
doaj   +1 more source