Results 31 to 40 of about 84,621 (282)

Desaturase Genes And Their Use (Patent US 6897050 B1) [PDF]

, 2005
cDNA encoding C. elegans Delta6 desaturase has been cloned and sequenced, and the Delta6 desaturase amino acid sequence has been determined: The C. elegans Delta6 desaturase has a surprisingly low level of sequence identity with the known borage Delta6 ...
Napier, J. A.
core   +3 more sources

Functional Analysis of the C-5 Sterol Desaturase PcErg3 in the Sterol Auxotrophic Oomycete Pathogen Phytophthora capsici

Frontiers in Microbiology, 2022
Although sterols play an important role in most eukaryotes, some oomycetes, including Phytophthora spp., have lost the sterol synthesis pathway. Nevertheless, the ERG3 gene encoding C-5 sterol desaturase in the sterol synthesis pathway is still present ...
Weizhen Wang, Tongshan Cui, Fan Zhang, Zhaolin Xue, Borui Zhang, Xili Liu, Xili Liu   +6 more
doaj   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity[S]

Journal of Lipid Research, 2012
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated FA. Mice with whole-body or skin-specific deletion of SCD1 are resistant to obesity.
Matthew T. Flowers, Lacmbouh Ade, Maggie S. Strable, James M. Ntambi   +3 more
doaj   +1 more source

Apocryphal FADS2 activity promotes fatty acid diversification in cancer

Cell Reports, 2021
Summary: Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation.
Reuben S.E. Young, Andrew P. Bowman, Elizabeth D. Williams, Kaylyn D. Tousignant, Charles L. Bidgood, Venkateswara R. Narreddula, Rajesh Gupta, David L. Marshall, Berwyck L.J. Poad, Colleen C. Nelson, Shane R. Ellis, Ron M.A. Heeren, Martin C. Sadowski, Stephen J. Blanksby   +13 more
doaj   +1 more source

Transcriptional regulation in bacterial membrane lipid synthesis

Journal of Lipid Research, 2009
This review covers the main transcriptional mechanisms that control membrane phospholipid synthesis in bacteria. The fatty acid components are the most energetically expensive modules to produce; thus, the regulation of fatty acid production is very ...
Yong-Mei Zhang, Charles O. Rock
doaj   +1 more source

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Frontiers in Plant Science, 2020
It is of great importance to combine stress tolerance and plant quality for breeding research. In this study, the role of phytoene desaturase (PDS), ζ-carotene desaturase (ZDS) and carotene isomerase (CRTISO) in the carotenoid biosynthesis are correlated
Chen Li, Jing Ji, Gang Wang, Zhaodi Li, Yurong Wang, Yajun Fan   +5 more
doaj   +1 more source

Complex Interactions Between Circulating Fatty Acid Levels, Desaturase Activities, and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study

Frontiers in Nutrition, 2022
ObjectiveMaternal abnormal fatty acid desaturation has previously been linked to gestational diabetes mellitus (GDM). However, few studies have investigated this relationship longitudinally throughout pregnancy.
Yue Liu, Yue Liu, Yue Liu, Yin-Yin Xia, Yin-Yin Xia, Ting Zhang, Yang Yang, Yang Yang, Richard D. Cannon, Toby Mansell, Toby Mansell, Boris Novakovic, Boris Novakovic, Richard Saffery, Richard Saffery, Ting-Li Han, Ting-Li Han, Ting-Li Han, Hua Zhang, Hua Zhang, Philip N. Baker   +20 more
doaj   +1 more source

The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe [PDF]

, 2003
Recent studies have identified a new family of desaturase-like polypeptide sequences in many higher eukaryotes. Functional characterisation of one member of this family, from Schizosaccharomyces pombe, revealed the enzyme to be a sphingolipid desaturase.
Beale, Michael H., Garton, Sarah, Michaelson, L. V., Napier, Johnathan A., Michael H. Beale, Beaudoin, Frédéric, Sarah Garton, Beale, M. H., Johnathan A. Napier, Michaelson, Louise V., Louise V. Michaelson, Napier, J. A., Frédéric Beaudoin, Beaudoin, F., Garton, S.   +14 more
core   +1 more source

Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

eLife
Polyunsaturated fatty acids (PUFAs) are essential for mammalian health and function as membrane fluidizers and precursors for signaling lipids, though the primary essential function of PUFAs within organisms has not been established.
Delaney Kaper, Uroš Radović, Per-Olof Bergh, August Qvist, Marcus Henricsson, Jan Borén, Marc Pilon   +6 more
doaj   +1 more source