Results 41 to 50 of about 80,074 (304)

Apocryphal FADS2 activity promotes fatty acid diversification in cancer

Cell Reports, 2021
Summary: Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation.
Reuben S.E. Young, Andrew P. Bowman, Elizabeth D. Williams, Kaylyn D. Tousignant, Charles L. Bidgood, Venkateswara R. Narreddula, Rajesh Gupta, David L. Marshall, Berwyck L.J. Poad, Colleen C. Nelson, Shane R. Ellis, Ron M.A. Heeren, Martin C. Sadowski, Stephen J. Blanksby   +13 more
doaj   +1 more source

Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes

Frontiers in Nutrition, 2018
This study aimed to evaluate whether resveratrol (RSV) and its microbial metabolites dihydro-resveratrol (DHR) and lunularin (LUN) affected fatty acid metabolism and omega-3 polyunsaturated fatty acid (n3-PUFA) synthesis in cultured hepatocytes.
Gianna Kühn, Kathrin Pallauf, Carsten Schulz, Carsten Schulz, Marc Birringer, Beatriz Diaz-Rica, Sonia de Pascual-Teresa, Gerald Rimbach   +7 more
doaj   +1 more source

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Frontiers in Plant Science, 2020
It is of great importance to combine stress tolerance and plant quality for breeding research. In this study, the role of phytoene desaturase (PDS), ζ-carotene desaturase (ZDS) and carotene isomerase (CRTISO) in the carotenoid biosynthesis are correlated
Chen Li, Jing Ji, Gang Wang, Zhaodi Li, Yurong Wang, Yajun Fan   +5 more
doaj   +1 more source

Complex Interactions Between Circulating Fatty Acid Levels, Desaturase Activities, and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study

Frontiers in Nutrition, 2022
ObjectiveMaternal abnormal fatty acid desaturation has previously been linked to gestational diabetes mellitus (GDM). However, few studies have investigated this relationship longitudinally throughout pregnancy.
Yue Liu, Yue Liu, Yue Liu, Yin-Yin Xia, Yin-Yin Xia, Ting Zhang, Yang Yang, Yang Yang, Richard D. Cannon, Toby Mansell, Toby Mansell, Boris Novakovic, Boris Novakovic, Richard Saffery, Richard Saffery, Ting-Li Han, Ting-Li Han, Ting-Li Han, Hua Zhang, Hua Zhang, Philip N. Baker   +20 more
doaj   +1 more source

Isolation of a Delta(5)-fatty acid desaturase gene from Mortierella alpina [PDF]

, 1998
Arachidonic acid (C20:4 Δ5,8,11,14)) is a polyunsaturated fatty acid synthesized by the ?-fatty acid desaturation of di-homo-?-linolenic acid (C20:3 Δ8,11,14)).
Michaelson, L. V., Michaelson, Louise V., Stobart, A. K., Napier, Johnathan A., Stobart, A.Keith, Napier, J. A., Griffiths, G., Griffiths, Gareth, Lazarus, C. M., Lazarus, Colin M.   +9 more
core   +1 more source

Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity

Angewandte Chemie, EarlyView.
A native ene‐reductase, XenA, was repurposed to catalyze the reverse‐enantioselective desaturation of cyclohexanones. The final variant was obtained through extensive protein engineering, combining PROSS‐guided computational design with mutagenesis and screening.
Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu   +4 more
wiley   +2 more sources

A new class of lipid desaturases: Identification of the Δ4 sphingoid base desaturase

Biochemical Society Transactions, 2002
Abstract
Garton, S., Michaelson, L. V., Beaudoin, F., Napier, J. A.   +3 more
openaire   +1 more source

Stearoyl coenzyme A desaturase [PDF]

Translational Research in Oral Oncology, 2018
Background: Oral cancer is a major public health problem in many parts of South Asia and ranking third among the cancer types in India. Numerous diagnostic, prognostic and metastatic biomarkers have been employed till date to assess various carcinomas.
Marin Abraham, SV Sowmya, Roopa S Rao, Vanishri C Haragannavar, Shankargouda Patil, Dominic Augustine, Shwetha Nambiar   +6 more
openaire   +1 more source

Expression Profiling of Lipolytic and Long-Chain Fatty Acid Biosynthesis Genes in Catfish Larvae Fed With Graded Lipid Levels

Frontiers in Marine Science, 2020
This study was designed to evaluate the effect of dietary lipid levels on the mRNA transcripts of lipid metabolic regulatory genes. Nine combinations of experimental diets containing graded lipid (80, 100, and 120 g/kg) and protein (450, 500, and 550 g ...
Ishfaq Nazir Mir, P. P. Srivastava, Irfan Ahmad Bhat, Jaffer Yousuf Dar, Deepak Agarwal   +4 more
doaj   +1 more source

The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases

Lifestyle Genomics, 2020
Background: At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids.
Michael A. Schmidt, Cem Meydan, Caleb M. Schmidt, Ebrahim Afshinnekoo, Christopher E. Mason   +4 more
doaj   +1 more source