Results 21 to 30 of about 80,074 (304)

Light-Stress Response Mediated by the Transcription Factor KlMga2 in the Yeast Kluyveromyces lactis

Frontiers in Microbiology, 2021
In unicellular organisms like yeasts, which do not have specialized tissues for protection against environmental challenges, the presence of cellular mechanisms to respond and adapt to stress conditions is fundamental.
Ilaria Camponeschi, Arianna Montanari, Marzia Beccaccioli, Massimo Reverberi, Cristina Mazzoni, Michele M. Bianchi   +5 more
doaj   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Temperature Acclimation of the Picoalga Ostreococcus tauri Triggers Early Fatty-Acid Variations and Involves a Plastidial ω3-Desaturase

Frontiers in Plant Science, 2021
Alteration of fatty-acid unsaturation is a universal response to temperature changes. Marine microalgae display the largest diversity of polyunsaturated fatty-acid (PUFA) whose content notably varies according to temperature.
Charlotte Degraeve-Guilbault, Nattiwong Pankasem, Maurean Gueirrero, Cécile Lemoigne, Frédéric Domergue, Tomonori Kotajima, Iwane Suzuki, Jérôme Joubès, Florence Corellou   +8 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. [PDF]

, 2006
Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA).
Renaville, B, Mullen, Anne, Anne Mullen, Moloney, F, RENAVILLE, Benedicte France Ghislaine, MOLONEY F, LARONDELLE Y, Helen M. Roche, Molonay, Fiona, Roche, HM, Fiona Moloney, Yvan Larondelle, Mullen, A, Renaville Bénédicte, Moloney, Fiona, Larondelle, Yvan, Yves-Jacques Schneider, MULLEN A, SCHNEIDER YJ ROCHE HM, Roche, Hélèje M., Renaville, Bénédicte, Roche, Helen M, Larondelle, Y, Schneider, Yves-Jacques   +23 more
core   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity[S]

Journal of Lipid Research, 2012
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated FA. Mice with whole-body or skin-specific deletion of SCD1 are resistant to obesity.
Matthew T. Flowers, Lacmbouh Ade, Maggie S. Strable, James M. Ntambi   +3 more
doaj   +1 more source

Lipid profiles of Mediterranean moray, Muraena helena, European conger, Conger conger, and European eel, Anguilla anguilla (Actinopterygii: Anguilliformes) [PDF]

Acta Ichthyologica et Piscatoria, 2017
Background. The current topics in fish fatty acid (FA) research include qualitative comparisons, trophic transfer as nutritive sources of FA, evolutionary comparison of synthesis pathways, and potential application of most efficient fish desaturases and ...
D. Đikić, I. Landeka, R. Fuchs, D. Skaramuca, S. Matić-Skoko, P. Tutman, Z. Franić, I. Cvetković, B. Skaramuca   +8 more
doaj   +3 more sources

Transcriptional regulation in bacterial membrane lipid synthesis

Journal of Lipid Research, 2009
This review covers the main transcriptional mechanisms that control membrane phospholipid synthesis in bacteria. The fatty acid components are the most energetically expensive modules to produce; thus, the regulation of fatty acid production is very ...
Yong-Mei Zhang, Charles O. Rock
doaj   +1 more source