Results 51 to 60 of about 84,621 (282)

Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

eLife, 2020
The surface of insects is coated in cuticular hydrocarbons (CHCs); variations in the composition of this layer affect a range of traits including adaptation to arid environments and defence against pathogens and toxins.
Linda Grigoraki, Xavier Grau-Bové, Henrietta Carrington Yates, Gareth J Lycett, Hilary Ranson   +4 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

A vertebrate fatty acid desaturase with delta5 and delta6 activities [PDF]

, 2001
Δ5 and Δ6 fatty acid desaturases are critical enzymes in the pathways for the biosynthesis of the polyunsaturated fatty acids (PUFA) arachidonic, eicosapentanoic and docosahexanoic acids.
Sargent, John R, Teale, Alan J, Tocher, Douglas R, Agaba, Morris K, Hastings, Nicola, Leaver, Michael, Dick, James R   +6 more
core   +1 more source

Desaturase Genes And Their Use (Patent CA 2311472 A1)

, 1999
cDNA encoding C. elegans .DELTA.6 desaturase has been cloned and sequenced, and the .DELTA.6 desaturase amino acid sequence has been determined. The C.
Napier, J. A.
core   +2 more sources

Stearoyl-CoA desaturase and tumorigenesis

Chemico-Biological Interactions, 2020
Stearoyl-CoA desaturase (SCD) generates monounsaturated fatty acids (MUFAs) which contribute to cell growth, survival, differentiation, metabolic regulation and signal transduction. Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease.
Kohtaro, Kikuchi, Hidekazu, Tsukamoto
openaire   +3 more sources

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Characterisation of the delta11-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera: Noctuidae)

, 1992
One of the key enzymes involved in moth pheromone biosynthesis, palmitoyl-CoA Δ11-desaturase, has been characterized in subcellular fractions from pheromonal glands of adult female Spodoptera littoralis.
Pickett, J. A., Hallahan, D. L., Camps, F., Rodriguez, F.   +3 more
core   +1 more source

Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells

Frontiers in Immunology, 2018
Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised.
Charlene M. Sibbons, Charlene M. Sibbons, Nicola A. Irvine, J. Eduardo Pérez-Mojica, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge   +7 more
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Nutritional regulation of stearoyl-CoA desaturase in the bovine mammary gland [PDF]

, 2011
Increasing the proportion of unsaturated fatty acids (UFA) in milk is believed to be beneficial in terms of human health, thereby increasing the nutritional quality of milk.
Jacobs, A.A.A.
core