Results 61 to 70 of about 80,074 (304)

Characterisation of the delta11-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera: Noctuidae)

, 1992
One of the key enzymes involved in moth pheromone biosynthesis, palmitoyl-CoA Δ11-desaturase, has been characterized in subcellular fractions from pheromonal glands of adult female Spodoptera littoralis.
Pickett, J. A., Hallahan, D. L., Camps, F., Rodriguez, F.   +3 more
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Nothing can replace polyunsaturated lipids

eLife
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
Sofia Rodriguez-Gallardo, Takeshi Harayama   +1 more
doaj   +1 more source

Desaturase Genes And Their Use (Patent US 6897050 B1) [PDF]

, 2005
cDNA encoding C. elegans Delta6 desaturase has been cloned and sequenced, and the Delta6 desaturase amino acid sequence has been determined: The C. elegans Delta6 desaturase has a surprisingly low level of sequence identity with the known borage Delta6 ...
Napier, J. A.
core  

The alternative pathway C20 Δ8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5-fusion desaturase

, 2006
A cDNA encoding a C20 Δ8-desaturase was isolated from the free-living soil amoeba, Acanthamoeba castellanii and functionally characterised by heterologous expression. The open reading frame of the A.
Sayanova, Olga, Sayanova, O. V., Haslam, R. P., Napier, Johnathan A., Lazarus, Colin M., Qi, B., Lazarus, C. M., Lazarus, CM, Napier, JA, Haslam, R, Qi, B, Qi, Baoxiu, Haslam, Richard, Napier, J. A., Sayanova, O   +14 more
core   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Functional identification of a delta8-sphingolipid desaturase from Borago officinalis

, 2001
The similarities between Δ12- and Δ15-fatty acyl desaturase sequences were used to construct degenerate primers for PCR experiments with cDNA transcribed from mRNA of developing borage seeds.
Heinz, E., Libisch, B., Napier, J. A., Zahringer, U., Sperling, P.   +4 more
core   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Enzymes enabling the biosynthesis of various C20 polyunsaturated fatty acids in a sea urchin Hemicentrotus pulcherrimus

Open Biology
Sea urchins, integral to marine ecosystems and valued as a delicacy in Asia and Europe, contain physiologically important long-chain (>C20) polyunsaturated fatty acids (PUFA) in their gonads, including arachidonic acid (ARA, 20:4n-6), eicosapentaenoic ...
Yingying Peng, Yutaka Haga, Naoki Kabeya
doaj   +1 more source