Results 31 to 40 of about 2,715,237 (202)

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent WO 2011/006948 A1) [PDF]

, 2011
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid ...
Sayanova, O. V., Napier, J. A., Bauer, J.   +2 more
core   +3 more sources

The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases

Lifestyle Genomics, 2020
Background: At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids.
Michael A. Schmidt, Cem Meydan, Caleb M. Schmidt, Ebrahim Afshinnekoo, Christopher E. Mason   +4 more
doaj   +1 more source

Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species

Open Biology, 2023
Previous data revealed the unexpected presence of genes encoding for long-chain polyunsaturated fatty acid (LC-PUFA) biosynthetic enzymes in transcriptomes from freshwater gammarids but not in marine species, even though closely related species were ...
Alberto Ribes-Navarro, Naoki Kabeya, L. Filipe C. Castro, André Gomes-dos-Santos, Miguel M. Fonseca, Hilke Alberts-Hubatsch, Francisco Hontoria, Juan C. Navarro, Óscar Monroig   +8 more
doaj   +1 more source

Cryptosporidium parvum Long-Chain Fatty Acid Elongase [PDF]

Eukaryotic Cell, 2007
ABSTRACT We report the presence of a new fatty acyl coenzyme A (acyl-CoA) elongation system in Cryptosporidium and the functional characterization of the key enzyme, a single long-chain fatty acid elongase (LCE), in this parasite.
Jason M, Fritzler, Jason J, Millership, Guan, Zhu   +2 more
openaire   +2 more sources

Isolation and Characterization of the Diatom Phaeodactylum Δ5-Elongase Gene for Transgenic LC-PUFA Production in Pichia pastoris

Marine Drugs, 2014
The diatom Phaeodactylum tricornutum can accumulate eicosapentaenoic acid (EPA) up to 30% of the total fatty acids. This species has been targeted for isolating gene encoding desaturases and elongases for long-chain polyunsaturated fatty acid (LC-PUFA ...
Mulan Jiang, Bing Guo, Xia Wan, Yangmin Gong, Yinbo Zhang, Chuanjiong Hu   +5 more
doaj   +1 more source

Reduced erythrocyte membrane polyunsaturated fatty acid levels indicate diminished treatment response in patients with multi- versus first-episode schizophrenia

npj Schizophrenia, 2022
Antipsychotic effects seem to decrease in relapsed schizophrenia patients and the underlying mechanisms remain to be elucidated. Based on the essential role of polyunsaturated fatty acids in brain function and the treatment of schizophrenia, we ...
Nana Li, Ping Yang, Mimi Tang, Yong Liu, Wenbin Guo, Bing Lang, Jianjian Wang, Haishan Wu, Hui Tang, Yan Yu, Xiangxin Wu, Cuirong Zeng, Ting Cao, Hualin Cai   +13 more
doaj   +1 more source

Functional analysis of leishmania cyclopropane fatty acid synthetase [PDF]

, 2012
The single gene encoding cyclopropane fatty acid synthetase (CFAS) is present in Leishmania infantum, L. mexicana and L. braziliensis but absent from L. major, a causative agent of cutaneous leishmaniasis. In L.
Mottram Jeremy C., Evans, K.J., Samuel O. Oyola (112546), Barbara A. Smith (112553), Smith, Barbara A., Terry K Smith, Smith Barbara A., Samuel O Oyola, Smith, Deborah F., Paul M Kaye, James D. Hilley (112558), Kaye, Paul M., Evans, Krystal J., Smith, Terry K., Smith, B.A., Oyola, Samuel O., Hilley, J.D., Mottram, J.C., Kaye, P.M., Oyola, S.O., Jeremy C. Mottram (112563), Smith Terry K., Terry K. Smith (112550), Smith, D.F., Mottram, Jeremy C., Hilley James D., Oyola Samuel O., Paul M. Kaye (54054), Deborah F. Smith (112029), Krystal J Evans, Evans Krystal J., Jeremy C Mottram, Kaye Paul M., James D Hilley, Smith, T.K., Barbara A Smith, Krystal J. Evans (112547), Smith Deborah F., Deborah F Smith, Hilley, James D.   +39 more
core   +1 more source

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1) [PDF]

, 2017
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid ...
Sayanova, O. V., Napier, J. A., Bauer, J.   +2 more
core   +3 more sources

Tackling functional redundancy of Arabidopsis fatty acid elongase complexes

Frontiers in Plant Science, 2023
Very-long-chain fatty acids (VLCFA) are precursors for various lipids playing important physiological and structural roles in plants. Throughout plant tissues, VLCFA are present in multiple lipid classes essential for membrane homeostasis, and also stored in triacylglycerols.
Marguerite Batsale, Marie Alonso, Marie Alonso, Stéphanie Pascal, Didier Thoraval, Richard P. Haslam, Frédéric Beaudoin, Frédéric Domergue, Jérôme Joubès   +8 more
openaire   +5 more sources

The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma [PDF]

Blood Advances, 2021
AbstractResistance to the proteasome inhibitor bortezomib (BTZ) represents a major obstacle in the treatment of multiple myeloma (MM). The contribution of lipid metabolism in the resistance of MM cells to BTZ is mostly unknown. Here we report that levels of fatty acid elongase 6 (ELOVL6) were lower in MM cells from BTZ-nonresponsive vs BTZ-responsive ...
Brittany C. Lipchick, Adam Utley, Zhannan Han, Sudha Moparthy, Dong Hyun Yun, Anna Bianchi-Smiraglia, David W. Wolff, Emily Fink, Liang Liu, Cristina M. Furdui, Jingyun Lee, Kelvin P. Lee, Mikhail A. Nikiforov   +12 more
openaire   +2 more sources