Results 31 to 40 of about 633,143 (229)
Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. [PDF]
PLoS Pathogens, 2013 Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To
Emre Koyuncu +3 more
doaj +1 more source
Identification and Expression of a Rat Fatty Acid Elongase Involved in the Biosynthesis of C18 Fatty Acids [PDF]
Bioscience, Biotechnology, and Biochemistry, 2002 A major part of the palmitic acid (C16:0) generated by fatty acid synthase is converted into stearic acid (C18:0) via carbon chain elongation. Here, we describe the cloning and expression of a rat hepatic enzyme, rELO2, responsible for the elongation of C16:0, presumably at the condensing reaction.
INAGAKI, Katsuya +6 more
openaire +2 more sources
Fatty acid elongase is required for shoot development in rice [PDF]
The Plant Journal, 2011 SummaryOrganisms are covered extracellularly with cuticular waxes that consist of various fatty acids. In higher plants, extracellular waxes act as indispensable barriers to protect the plants from physical and biological stresses such as drought and pathogen attacks.
Yukihiro, Ito +7 more
openaire +2 more sources
Open Biology, 2021 The long-standing paradigm establishing that global production of Omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFA) derived almost exclusively from marine single-cell organisms, was recently challenged by the discovery that multiple ...
Naoki Kabeya +6 more
doaj +1 more source
YAKUGAKU ZASSHI, 2022 The increasing prevalence of obesity worldwide has become an alarming public health concern because of dramatic increases in the incidence of obesity-associated diseases, including type 2 diabetes mellitus (T2DM). Peripheral insulin resistance and impaired insulin secretion remain the core defects in T2DM. Despite significant advances in unraveling the
Takashi, Matsuzaka, Hitoshi, Shimano
openaire +2 more sources
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma [PDF]
Blood Advances, 2021 AbstractResistance to the proteasome inhibitor bortezomib (BTZ) represents a major obstacle in the treatment of multiple myeloma (MM). The contribution of lipid metabolism in the resistance of MM cells to BTZ is mostly unknown. Here we report that levels of fatty acid elongase 6 (ELOVL6) were lower in MM cells from BTZ-nonresponsive vs BTZ-responsive ...
Brittany C. Lipchick +12 more
openaire +2 more sources
Tackling functional redundancy of Arabidopsis fatty acid elongase complexes
Frontiers in Plant Science, 2023 Very-long-chain fatty acids (VLCFA) are precursors for various lipids playing important physiological and structural roles in plants. Throughout plant tissues, VLCFA are present in multiple lipid classes essential for membrane homeostasis, and also stored in triacylglycerols.
Marguerite Batsale +8 more
openaire +5 more sources
Cryptosporidium parvum Long-Chain Fatty Acid Elongase [PDF]
Eukaryotic Cell, 2007 ABSTRACT We report the presence of a new fatty acyl coenzyme A (acyl-CoA) elongation system in Cryptosporidium and the functional characterization of the key enzyme, a single long-chain fatty acid elongase (LCE), in this parasite.
Jason M, Fritzler +2 more
openaire +2 more sources
Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERα in Breast Cancer Cells. [PDF]
PLoS ONE, 2016 Endocrine therapy is the first-line targeted adjuvant therapy for hormone-sensitive breast cancer. In view of the potential anticancer property of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) together with chemotherapy in estrogen ...
Amanda González-Bengtsson +4 more
doaj +1 more source
Journal of Animal Science and Biotechnology, 2022 Background In rodents, research has revealed a role of liver X receptors (LXR) in controlling lipid homeostasis and regulating the synthesis of polyunsaturated fatty acids (PUFA).
Wenying Zhang +6 more
doaj +1 more source