Results 41 to 50 of about 633,143 (229)

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Frontiers in Molecular Neuroscience, 2021
BackgroundLipids are a primary storage form of energy and the source of inflammatory and pain signaling molecules, yet knowledge of their importance in chronic migraine (CM) pathology is incomplete.
Katherine Castor, Jessica Dawlaty, Xianghong Arakaki, Xianghong Arakaki, Noah Gross, Yohannes W. Woldeamanuel, Michael G. Harrington, Michael G. Harrington, Michael G. Harrington, Robert P. Cowan, Alfred N. Fonteh, Alfred N. Fonteh   +11 more
doaj   +1 more source

ONION2 Fatty Acid Elongase is Required for Shoot Development in Rice [PDF]

Plant and Cell Physiology, 2012
A plant's surface is covered with epicuticular wax, which protects plants from inappropriate environmental conditions such as drought and pathogen attack. Very-long-chain fatty acids (VLCFAs) are the main component of epicuticular wax on the surface of above-ground organs.
Tsuda, Katsutoshi, Akiba, Takafumi, Kimura, Fumiko, Ishibashi, Mayu, Moriya, Chihiro, Nakagawa, Kiyotaka, Kurata, Nori, Ito, Yukihiro   +7 more
openaire   +2 more sources

Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases

Molecules, 2022
The essential fatty acid alpha-linolenic acid (ALA) is present in high amounts in oils such as flaxseed, soy, hemp, rapeseed, chia, and perilla, while stearidonic acid is abundant in echium oil.
Marija Takic, Biljana Pokimica, Gordana Petrovic-Oggiano, Tamara Popovic   +3 more
doaj   +1 more source

De novo synthesis of nervonic acid and optimization of metabolic regulation by Yarrowia lipolytica

Bioresources and Bioprocessing, 2023
Nervonic acid, a natural fatty acid compound and also a core component of nerve fibers and nerve cells, has been widely used to prevent and treat related diseases of the brain nervous system.
Xin-Ru Zhao, Xin-Liang Chen, Jing-Lin Yang, Qi Gao, Jiang-Ting Shi, Qiang Hua, Liu-Jing Wei   +6 more
doaj   +1 more source

Elongases of Long-Chain Fatty Acids ELO2 and ELO9 Are Involved in Cuticle Formation and Function in Fecundity in the Yellow Fever Mosquito, Aedes aegypti

Insects, 2023
Long-chain fatty acid elongases (ELOs) play important roles in the metabolism of fatty acids in insects. In this study, the genes for two elongases from Aedes aegypti were identified, AeELO2 and AeELO9.
Jing Chen, Yu-Chen Wu, Jiu-Kai Chen, Xiao-Jing Zhu, David Merkler, Cheng-Hong Liao, Qian Han   +6 more
doaj   +1 more source

Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species

Open Biology, 2023
Previous data revealed the unexpected presence of genes encoding for long-chain polyunsaturated fatty acid (LC-PUFA) biosynthetic enzymes in transcriptomes from freshwater gammarids but not in marine species, even though closely related species were ...
Alberto Ribes-Navarro, Naoki Kabeya, L. Filipe C. Castro, André Gomes-dos-Santos, Miguel M. Fonseca, Hilke Alberts-Hubatsch, Francisco Hontoria, Juan C. Navarro, Óscar Monroig   +8 more
doaj   +1 more source

Reduced erythrocyte membrane polyunsaturated fatty acid levels indicate diminished treatment response in patients with multi- versus first-episode schizophrenia

npj Schizophrenia, 2022
Antipsychotic effects seem to decrease in relapsed schizophrenia patients and the underlying mechanisms remain to be elucidated. Based on the essential role of polyunsaturated fatty acids in brain function and the treatment of schizophrenia, we ...
Nana Li, Ping Yang, Mimi Tang, Yong Liu, Wenbin Guo, Bing Lang, Jianjian Wang, Haishan Wu, Hui Tang, Yan Yu, Xiangxin Wu, Cuirong Zeng, Ting Cao, Hualin Cai   +13 more
doaj   +1 more source

Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release

Science Advances, 2023
Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells and purified extracellular quasi-enveloped virions with high-throughput RNA
Tomoyuki Shiota, Zhucui Li, Guan-Yuan Chen, K. McKnight, Takayoshi Shirasaki, Bryan Yonish, Hey-Ran Kim, Ethan J. Fritch, T. Sheahan, Masamichi Muramatsu, M. Kapustina, Craig E. Cameron, You Li, Qibin Zhang, Stanley M. Lemon   +14 more
semanticscholar   +1 more source

Isolation and Characterization of the Diatom Phaeodactylum Δ5-Elongase Gene for Transgenic LC-PUFA Production in Pichia pastoris

Marine Drugs, 2014
The diatom Phaeodactylum tricornutum can accumulate eicosapentaenoic acid (EPA) up to 30% of the total fatty acids. This species has been targeted for isolating gene encoding desaturases and elongases for long-chain polyunsaturated fatty acid (LC-PUFA ...
Mulan Jiang, Bing Guo, Xia Wan, Yangmin Gong, Yinbo Zhang, Chuanjiong Hu   +5 more
doaj   +1 more source

Functional analysis of leishmania cyclopropane fatty acid synthetase [PDF]

, 2012
The single gene encoding cyclopropane fatty acid synthetase (CFAS) is present in Leishmania infantum, L. mexicana and L. braziliensis but absent from L. major, a causative agent of cutaneous leishmaniasis. In L.
Mottram Jeremy C., Evans, K.J., Samuel O. Oyola (112546), Barbara A. Smith (112553), Smith, Barbara A., Terry K Smith, Smith Barbara A., Samuel O Oyola, Smith, Deborah F., Paul M Kaye, James D. Hilley (112558), Kaye, Paul M., Evans, Krystal J., Smith, Terry K., Smith, B.A., Oyola, Samuel O., Hilley, J.D., Mottram, J.C., Kaye, P.M., Oyola, S.O., Jeremy C. Mottram (112563), Smith Terry K., Terry K. Smith (112550), Smith, D.F., Mottram, Jeremy C., Hilley James D., Oyola Samuel O., Paul M. Kaye (54054), Deborah F. Smith (112029), Krystal J Evans, Evans Krystal J., Jeremy C Mottram, Kaye Paul M., James D Hilley, Smith, T.K., Barbara A Smith, Krystal J. Evans (112547), Smith Deborah F., Deborah F Smith, Hilley, James D.   +39 more
core   +1 more source