Fatty Acid Synthesis by Elongases in Trypanosomes [PDF]
Cell, 2006 All eukaryotic and prokaryotic organisms are thought to synthesize fatty acids using a type I or type II synthase. In addition, eukaryotes extend pre-existing long chain fatty acids using microsomal elongases (ELOs). We have found that Trypanosoma brucei, a eukaryotic human parasite that causes sleeping sickness, uses three elongases instead of type I ...
Kimberly S Paul, Paul T Englund
exaly +4 more sources
Lifestyle Genomics, 2020 Background: At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids.
Michael A. Schmidt +4 more
doaj +3 more sources
Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases [PDF]
Marine Drugs, 2021 Long-chain (C20–24) polyunsaturated fatty acids (LC-PUFAs) are essential nutrients that are mostly produced in marine ecosystems. Previous studies suggested that gammarids have some capacity to endogenously produce LC-PUFAs.
Alberto Ribes-Navarro +6 more
doaj +3 more sources
Characterization of Entamoeba fatty acid elongases; validation as targets and provision of promising leads for new drugs against amebiasis. [PDF]
PLoS PathogensEntamoeba histolytica is a protozoan parasite belonging to the phylum Amoebozoa that causes amebiasis, a global public health problem. E. histolytica alternates its form between a proliferative trophozoite and a dormant cyst. Trophozoite proliferation is
Fumika Mi-Ichi +5 more
doaj +3 more sources
Cloning and functional characterisation of polyunsaturated fatty acid elongases of marine and freshwater teleost fish [PDF]
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005 Enzymes that lengthen the carbon chain of polyunsaturated fatty acids are key to the biosynthesis of the highly unsaturated fatty acids, arachidonic, eicosapentaenoic and docosahexaenoic acids from linoleic and α-linolenic acids.
Douglas R Tocher, Xiaozhong Zheng
exaly +3 more sources
A workflow to explore elongase diversity and extend the repertoire of fatty acids produced by Yarrowia lipolytica [PDF]
Microbial Cell FactoriesBackground Fatty acids display highly diverse structures that confer these molecules unique chemical properties and distinct physiological functions.
Jérémy Le Reun +5 more
doaj +2 more sources
Progress in Lipid Research, 2022 Marine ecosystems are rich in "omega-3" long-chain (C20-24) polyunsaturated fatty acids (LC-PUFA). Their production has been historically accepted to derive mostly from marine microbes.
Alexander Chong Shu-Chien +2 more
exaly +2 more sources
Long-chain polyunsaturated fatty acid biosynthesis in the euryhaline herbivorous teleost Scatophagus argus: Functional characterization, tissue expression and nutritional regulation of two fatty acyl elongases. [PDF]
Comparative Biochemistry and Physiology Part B Comparative Biochemistry, 2016 Both the spotted scat Scatophagus argus and rabbitfish Siganus canaliculatus belong to the few cultured herbivorous marine teleost, however, their fatty acyl desaturase (Fad) system involved in long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis
Dizhi Xie +8 more
semanticscholar +2 more sources
Characterization of Three Types of Elongases from Different Fungi and Site-Directed Mutagenesis
Journal of FungiFatty acid elongases play crucial roles in synthesizing long-chain polyunsaturated fatty acids. Identifying more efficient elongases is essential for enhancing oleaginous microorganisms to produce high yields of target products.
Yuxin Wang +5 more
doaj +2 more sources
Scientific Reports, 2016 Cuticular hydrocarbons (CHCs) play a major role in the evolution of reproductive isolation between insect species. The CHC profiles of two closely related sympatric grasshopper species, Chorthippus biguttulus and C.
Jonas Finck +4 more
semanticscholar +2 more sources