Results 11 to 20 of about 2,715,237 (202)

Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis

Journal of Lipid Research, 2004
In algae, the biosynthesis of docosahexaenoic acid (22:6ω3; DHA) proceeds via the elongation of eicosapentaenoic acid (20:5ω3; EPA) to 22:5ω3, which is required as a substrate for the final Δ4 desaturation. To isolate the elongase specific for this step,
Astrid Meyer, Helene Kirsch, Frédéric Domergue, Amine Abbadi, Petra Sperling, Jörg Bauer, Petra Cirpus, Thorsten K. Zank, Hervé Moreau, Thomas J. Roscoe, Ulrich Zähringer, Ernst Heinz   +11 more
doaj   +3 more sources

Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases [PDF]

Journal of Lipid Research, 2005
Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult ...
Yun Wang, Daniela Botolin, Barbara Christian, Julia Busik, Jinghua Xu, Donald B. Jump   +5 more
doaj   +3 more sources

Mammalian fatty acid elongases. [PDF]

Methods Mol Biol, 2009
Very long chain fatty acids confer functional diversity on cells by variations in their chain length and degree of unsaturation. Microsomal fatty acid elongation represents the major pathway for determining the chain length of saturated, monounsaturated, and polyunsaturated fatty acids in cellular lipids.
Jump DB.
europepmc   +4 more sources

The structural basis of fatty acid elongation by the ELOVL elongases [PDF]

Nature Structural & Molecular Biology, 2020
Abstract Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids required for nerve, skin and retina function and 3-keto acyl-CoA synthases (ELOVL elongases) perform the first step in the FA elongation cycle.
Nie, L, Pascoa, TC, Pike, ACW, Bushell, SR, Quigley, A, Ruda, GF, Chu, A, Cole, V, Speedman, D, Moreira, T, Shrestha, L, Mukhopadhyay, SMM, Burgess-Brown, NA, Love, JD, Brennan, PE, Carpenter, EP   +15 more
openaire   +6 more sources

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer [PDF]

Cancer Research, 2021
Abstract The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation of novel AR targeting therapies, outcomes for metastatic disease remain dismal. There is an urgent need to better understand androgen-regulated cellular processes to more effectively ...
Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler   +32 more
openaire   +7 more sources

Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction. [PDF]

Eur J Clin Nutr, 2012
Aslibekyan S, Jensen MK, Campos H, Linkletter CD, Loucks EB, Ordovas JM, Deka R, Rimm EB, Baylin A.   +8 more
europepmc   +2 more sources

Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases

Marine Drugs, 2021
Long-chain (C20–24) polyunsaturated fatty acids (LC-PUFAs) are essential nutrients that are mostly produced in marine ecosystems. Previous studies suggested that gammarids have some capacity to endogenously produce LC-PUFAs.
Alberto Ribes-Navarro, Juan C. Navarro, Francisco Hontoria, Naoki Kabeya, Inger B. Standal, Jan O. Evjemo, Óscar Monroig   +6 more
doaj   +1 more source

Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. [PDF]

PLoS Pathogens, 2013
Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To
Emre Koyuncu, John G Purdy, Joshua D Rabinowitz, Thomas Shenk   +3 more
doaj   +1 more source

Functional Characterization of the Chicken Fatty Acid Elongases [PDF]

The Journal of Nutrition, 2013
The health benefits of the (n-3) PUFA, EPA, and DHA have created a demand for fish and fish oil, the main sources of these PUFA. Production animals, such as poultry, are potential alternate and sustainable sources of EPA and DHA, provided these fatty acids can be synthesized from plant-derived α-linolenic acid [ALA, 18:3(n-3)].
Gregory, M., Geier, M., Gibson, R., James, M.   +3 more
openaire   +3 more sources

A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n–3) exists in the marine Harpacticoida copepod Tigriopus californicus

Open Biology, 2021
The long-standing paradigm establishing that global production of Omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFA) derived almost exclusively from marine single-cell organisms, was recently challenged by the discovery that multiple ...
Naoki Kabeya, Masanari Ogino, Hideki Ushio, Yutaka Haga, Shuichi Satoh, Juan C. Navarro, Óscar Monroig   +6 more
doaj   +1 more source