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Abstract Aims Heart failure with preserved ejection fraction (HFpEF) continues to be an increasingly common health problem associated with a high mortality rate. Elevated levels of Growth differentiation factor‐15 (GDF15) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) are reportedly associated with poor clinical outcomes in a broad range of ...
Yoichiro Otaki +11 more
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On the metabolic conversion of human plasma very low density lipoprotein to low density lipoprotein
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973Abstract The relationship of 125I-labelled apoproteins of very low density lipoprotein to that of other lipoproteins was studied in humans during steady-state conditions and following heparin injection. Heterogeneous metabolism of very low density lipo-protein apoproteins in normal individuals was apparent during steady-state conditions ...
S, Eisenberg +3 more
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Very-low-density lipoprotein assembly and secretion
Current Opinion in Lipidology, 2001The assembly of apolipoprotein B (apoB) into VLDL is broadly divided into two steps. The first involves transfer of lipid by the microsomal triglyceride transfer protein (MTP) to apoB during translation. The second involves fusion of apoB-containing precursor particles with triglyceride droplets to form mature VLDL. ApoB and MTP are homologs of the egg
G S, Shelness, J A, Sellers
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Very low density lipoprotein binding to adipocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980Human very low density lipoprotein (VLDL) has been found to interact with both isolated adipocytes and adipocyte membranes in a manner which is saturable, reversible and dependent on time and temperature. Except for a difference in maximum binding capacity, a similar pattern is seen with both rat epididymal adipocytes and human omental adipocytes.
K S, Desai +3 more
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Journal of Theoretical Biology, 1980
Abstract A new model for the catabolism of very low density lipoprotein will be proposed following a brief discussion of the relevant information about its metabolism. This model is based on the assumption that each very low density lipoprotein derivative has a distinct structural feature which determines its biological fate.
Y, Jeng, I, Jeng
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Abstract A new model for the catabolism of very low density lipoprotein will be proposed following a brief discussion of the relevant information about its metabolism. This model is based on the assumption that each very low density lipoprotein derivative has a distinct structural feature which determines its biological fate.
Y, Jeng, I, Jeng
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Clinica Chimica Acta, 1995
In some hyperlipidemic patients, low density lipoprotein (LDL) shows several peaks (polydisperse) on polyacrylamide gel disc electrophoreses, though LDL usually shows a single peak (monodisperse). In order to clarify the relationship between the LDL polydispersion and VLDL heterogeneity, LDL and VLDL were prepared from hyperlipidemic patients sera with
S, Saheki +5 more
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In some hyperlipidemic patients, low density lipoprotein (LDL) shows several peaks (polydisperse) on polyacrylamide gel disc electrophoreses, though LDL usually shows a single peak (monodisperse). In order to clarify the relationship between the LDL polydispersion and VLDL heterogeneity, LDL and VLDL were prepared from hyperlipidemic patients sera with
S, Saheki +5 more
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The catabolism of very low density lipoproteins
Canadian Journal of Biochemistry and Cell Biology, 1985The lipolysis of very low density lipoproteins (VLDL) in vitro is a useful model for the study of the process of conversion of this triacylglycerol rich lipoprotein into low (LDL) and high (HDL) density lipoproteins. Data is reviewed to show that a portion of surface cholesterol and phospholipid which becomes redundant during lipolysis is lost from ...
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Very low density lipoprotein receptor in Alzheimer disease
Microscopy Research and Technique, 2000The apolipoprotein (APO) E4 isoform is associated with an accelerated rate of Alzheimer disease (AD) expression in sporadic as well as late-onset familial forms of the disease but the precise mechanism is unknown. In an attempt to approach the possible mechanisms involved, APOE receptors have been studied. They all belong to the low density lipoprotein
N, Helbecque, P, Amouyel
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