Results 31 to 40 of about 290,183 (300)

Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria

Journal of Lipid Research, 2004
The use of lipoproteins has been suggested as a treatment for Gram-negative sepsis because they inhibit lipopolysaccharide (LPS)-mediated cytokine production.
Tom Sprong, Mihai G. Netea, Peter van der Ley, Trees J.G. Verver-Jansen, Liesbeth E.H. Jacobs, Anton Stalenhoef, Jos W.M. van der Meer, Marcel van Deuren   +7 more
doaj   +1 more source

Lipoprotein lipase releases esterified oxylipins from very low-density lipoproteins [PDF]

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2008
We previously demonstrated that defects in lipoprotein metabolism alter the distribution of oxygenated polyunsaturated fatty acids (PUFAs) in lipoprotein particles. If these oxidation products are released by lipoprotein lipase (LpL), then their delivery to peripheral tissues with bulk lipids could influence cellular function.
Gregory C, Shearer, John W, Newman
openaire   +2 more sources

ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice

Journal of Lipid Research, 2002
Apolipoprotein E (apoE) is essential for the clearance of plasma chylomicron and VLDL remnants. The human APOE locus is polymorphic and 5–10% of APOE*2 homozygotes exhibit type-III hyperlipoproteinemia (THL), while the remaining homozygotes have less ...
Myron E. Hinsdale, Patrick M. Sullivan, Hafid Mezdour, Nobuyo Maeda   +3 more
doaj   +1 more source

Study of serum lipid profile in the smokers

National Journal of Physiology, Pharmacy and Pharmacology, 2020
Background: Smoking of cigarettes has been found to alter lipoprotein levels. Smoking raises the blood total cholesterol (TC) content, triglycerides (TG), low-density lipoprotein (LDL), and very LDL (VLDL) and reduces the level of good cholesterol, i.e.,
S P Srinivas, Kamble Ganesh
doaj   +1 more source

ApoE genotype-specific inhibition of apoptosis

Journal of Lipid Research, 2003
Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoproteins ...
Robert M. DeKroon, Mirta Mihovilovic, Zoe V. Goodger, Jennifer B. Robinette, Patrick M. Sullivan, Ann M. Saunders, Warren J. Strittmatter   +6 more
doaj   +1 more source

Clinical outcome of a patient with lysosomal acid lipase deficiency and first results after initiation of treatment with Sebelipase alfa: A case report [PDF]

, 2019
We report on a case of very rare autosomal recessive cholesteryl ester storage disease due to lysosomal acid lipase deficiency (LALD). LALD is caused by mutations in the lysosomal acid lipase A (LIPA) gene resulting in cholesteryl ester accumulation in
Bobbert, Thomas, Demuth, Ilja, Haberbosch, Linus, Hollstein, Tim, Kassner, Ursula, Soll, Dominik, Spira, Dominik, Spranger, Joachim, Steinhagen-Thiessen, Elisabeth   +8 more
core   +1 more source

Characterization of apoM in normal and genetically modified mice

Journal of Lipid Research, 2004
A novel human apolipoprotein [apolipoprotein M (apoM)] was recently described and demonstrated to be a lipocalin. We have now examined apoM in wild-type mice and mice with genetically altered lipoprotein metabolism.
Kirsten Faber, Olof Axler, Björn Dahlbäck, Lars Bo Nielsen   +3 more
doaj   +1 more source

Metabolic profiling of fatty liver in young and middle-aged adults : Cross-sectional and prospective analyses of the Young Finns Study [PDF]

, 2016
Nonalcoholic fatty liver is associated with obesity-related metabolic disturbances, but little is known about the metabolic perturbations preceding fatty liver disease. We performed comprehensive metabolic profiling to assess how circulating metabolites,
Ala-Korpela, Mika, Hutri-Kähönen, Nina, Jula, Antti, Juonala, Markus, Kaikkonen, Jari E., Kangas, Antti J., Kähönen, Mika, Lehtimäki, Terho, Lehtovirta, Miia, Mikkilä, Vera, Raitakari, Olli T., Rönnemaa, Tapani, Soininen, Pasi, Suomela, Emmi, Viikari, Jorma S.A., Würtz, Peter   +15 more
core   +5 more sources

Long term hemodialysis aggravates lipolytic activity reduction and very low density, low density lipoproteins composition in chronic renal failure patients [PDF]

, 2009
Background Dyslipidemia, particularly hypertriglyceridemia is common in uremia, and represents an independent risk factor for atherosclerosis. Methods To investigate the effects of hemodialysis (HD) duration on very low density lipoprotein (VLDL) and low
Khedidja Mekki, Josiane Prost, Mustapha Remaoun, Jacques Belleville, Malika Bouchenak, JD Brunzell, I Akdag, A Kogan, CH Okechukwu, DT Chan, V Tsimihodimos, BH Prinsen, P Cullen, M Senti, MS Elisaf, C Ponticelli, O Ifudu, LB Haas, MA Sobh, G Paragh, K Mekki, K Mekki, P Nilsson-Ehle, P Nilsson-Ehle, RJ Havel, TG Redgrave, OH Lowry, CB Laurell, K Mekki, K Tsutsumi, K Mekki   +30 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source