Results 41 to 50 of about 290,183 (300)

Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake[S]

Journal of Lipid Research, 2013
The LDL receptor (LDLR) supports efficient uptake of both LDL and VLDL remnants by binding lipoprotein at the cell surface, internalizing lipoprotein through coated pits, and releasing lipoprotein in endocytic compartments before returning to the surface
Shanica Pompey, Zhenze Zhao, Kate Luby-Phelps, Peter Michaely   +3 more
doaj   +1 more source

Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease. [PDF]

, 2013
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Agnello, Aizaki, Amako, Amako, Anderson, Atsukawa, Bader, Bishop, Boulant, Bradley, Bradley, Brasaemle, Bulankina, Calland, Catherine Schuster, Chhatwal, Chojkier, Ciesek, Clark, Dallinga-Thie, Daniel Felmlee, Dao Thi, Dienes, Enjoji, Esau, Forde, Fraser, Goldwasser, Grove, Haid, Harrison, Herker, Hijikata, Hirata, Hsu, Huang, Icard, Ishibashi, Jopling, Kaito, Kanto, Koutsoudakis, Lambert, Lanford, Lin, Lindenbach, Mancone, Martin, Marzouk, Mathieu Lefevre, McHutchison, Meex, Meunier, Miyanari, Mohamed Hafirassou, Nahmias, Nakamuta, Nishimura, Packard, Pecheur, Petit, Poynard, Prentoe, Pumeechockchai, Ramcharran, Reiss, Rocha-Perugini, Roe, Romero-Brey, Sakamoto, Sarasin-Filipowicz, Scholtes, Schuster, Serfaty, Sezaki, Shavinskaya, Shi, Shimakami, Stanford, Targett-Adams, Thomas Baumert, Thomssen, Tsai, Voisset, Wakita, Weng, Westin, Ye, Zeisel   +88 more
core   +7 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Interaction of rat plasma very low density lipoprotein with lipoprotein lipase-rich (postheparin) plasma.

Journal of Lipid Research, 1975
Incubation of 125I-labeled very low density lipoprotein (VLDL) with lipoprotein lipase-rich (postheparin) plasma obtained from intact or supradiaphragmatic rats resulted in the transfer of more than 80% of apoprotein C from VLDL to high density ...
S Eisenberg, D Rachmilewitz
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Upregulation of hepatic VLDLR via PPARα is required for the triglyceride-lowering effect of fenofibrate

Journal of Lipid Research, 2014
The liver and the VLDL receptor (VLDLR) play major roles in TG and VLDL metabolism. However, the exact role of liver VLDLR is not well known because of the absence of or difficulty in detecting VLDLR in the liver.
Yang Gao, Wei Shen, Boyu Lu, Qingjiong Zhang, Yang Hu, Ying Chen   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Accuracy of low-density lipoprotein cholesterol estimation at very low levels

BMC Medicine, 2017
Background As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical efficacy and safety evaluation.
Renato Quispe, Aditya Hendrani, Mohamed B. Elshazly, Erin D. Michos, John W. McEvoy, Michael J. Blaha, Maciej Banach, Krishnaji R. Kulkarni, Peter P. Toth, Josef Coresh, Roger S. Blumenthal, Steven R. Jones, Seth S. Martin   +12 more
doaj   +1 more source

The Association Between Cardiovascular Risk and Elevated Triglycerides [PDF]

, 2017
BACKGROUND: The association between elevated triglycerides and cardiovascular risk has been extensively studied. The elevated level of triglycerides occurs through abnormalities in hepatic very low-density lipoprotein (VLDL) production and intestinal ...
Handayani, O. (Olivia), Sargowo, D. (Djanggan)   +1 more
core   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source