Results 21 to 30 of about 268,720 (256)

Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders

Cells, 2021
Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein localized to the Golgi apparatus and the cytosol. GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate [PI(4)P] and regulates Golgi architecture ...
Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D’Avino, Maria Grazia Giansanti   +7 more
doaj   +1 more source

A Direct Interaction between Cdc42 and Vesicle-associated Membrane Protein 2 Regulates SNARE-dependent Insulin Exocytosis [PDF]

Journal of Biological Chemistry, 2005
In pancreatic beta cells, insulin granule exocytosis is regulated by SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein (SNAP) receptor) proteins, and this is coupled to cortical F-actin reorganization via the Rho family GTPase Cdc42 by an unknown mechanism.
Angela K, Nevins, Debbie C, Thurmond
openaire   +2 more sources

Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation

Frontiers in Immunology, 2018
Vesicle-associated V-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins and target membrane-associated T-SNAREs (syntaxin 4 and SNAP-23) assemble into a core trans-SNARE complex that mediates membrane fusion during ...
Yoosoo Yang, Yoosoo Yang, Byoungjae Kong, Byoungjae Kong, Younghoon Jung, Younghoon Jung, Joon-Bum Park, Joon-Bum Park, Jung-Mi Oh, Jaesung Hwang, Jae Youl Cho, Jae Youl Cho, Dae-Hyuk Kweon, Dae-Hyuk Kweon   +13 more
doaj   +1 more source

Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting

JCI Insight, 2021
PDCD10, also known as CCM3, is a gene found to be associated with the human disease cerebral cavernous malformations (CCMs). PDCD10 forms a complex with GCKIII kinases including STK24, STK25, and MST4. Studies in C.
Rui Wang, Shi-Ting Wu, Xi Yang, Yude Qian, Jaesung P. Choi, Rui Gao, Siliang Song, Yixuan Wang, Tao Zhuang, Justin J.L. Wong, Yuzhen Zhang, Zhiming Han, Hua A. Lu, Stephen I. Alexander, Renjing Liu, Yin Xia, Xiangjian Zheng   +16 more
doaj   +1 more source

Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy [PDF]

Neuroscience, 2012
Our previous work has correlated permanent alterations in the rat neurosecretory machinery with epileptogenesis. Such findings highlighted the need for a greater understanding of the molecular mechanisms underlying epilepsy so that novel therapeutic regimens can be designed.
E A, Matveeva, D A, Price, S W, Whiteheart, T C, Vanaman, G A, Gerhardt, J T, Slevin   +5 more
openaire   +2 more sources

Vesicle-associated Membrane Protein (VAMP)/Synaptobrevin-2 Is Associated with Dense Core Secretory Granules in PC12 Neuroendocrine Cells [PDF]

Journal of Biological Chemistry, 1995
The presence and intracellular distribution of vesicle-associated membrane protein-1 (VAMP-1) and VAMP-2 were investigated in the PC12 neuroendocrine cell line using isotype-specific polyclonal antibodies. VAMP-2 was detected in the total membrane fraction, while VAMP-1 was undetectable.
PAPINI, EMANUELE, ROSSETTO O., CUTLER D.
openaire   +4 more sources

Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca Signalling

Contact, 2021
We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER– plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK regulation of ER-PM contacts was revealed by
Maria Livia Sassano, Rita Derua, Etienne Waelkens, Patrizia Agostinis, Alexander R van Vliet   +4 more
doaj   +1 more source

Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom

Toxins, 2017
Scorpions are among the oldest venomous living organisms and the family Buthidae is the largest and most medically relevant one. Scorpion venoms include many toxic peptides, but recently, a metalloprotease from Tityus serrulatus called antarease was ...
Irene Zornetta, Michele Scorzeto, Pablo Victor Mendes Dos Reis, Maria E. De Lima, Cesare Montecucco, Aram Megighian, Ornella Rossetto   +6 more
doaj   +1 more source

Apolipoproteins L1 and L3 control mitochondrial membrane dynamics

Cell Reports, 2023
Summary: Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular myosin 2A.
Laurence Lecordier, Paul Heo, Jonas H. Graversen, Dorle Hennig, Maria Kløjgaard Skytthe, Alexandre Cornet d’Elzius, Frédéric Pincet, David Pérez-Morga, Etienne Pays   +8 more
doaj   +1 more source

Expression of vesicle-associated membrane protein 2 (VAMP-2)/synaptobrevin II and cellubrevin in rat skeletal muscle and in a muscle cell line [PDF]

Biochemical Journal, 1994
Molecular studies have identified a family of synaptic vesicle-associated membrane proteins (VAMPs, also known as synaptobrevins) which have been implicated in synaptic vesicle docking and/or fusion with plasma membrane proteins. Here we demonstrate the expression of two members of this family, VAMP-2/synaptobrevin II and cellubrevin, in skeletal ...
A, Volchuk, Y, Mitsumoto, L, He, Z, Liu, E, Habermann, W, Trimble, A, Klip   +6 more
openaire   +2 more sources