Evidence that Electrostatic Interactions between Vesicle-associated Membrane Protein 2 and Acidic Phospholipids May Modulate the Fusion of Transport Vesicles with the Plasma Membrane [PDF]
Molecular Biology of the Cell, 2009 The juxtamembrane domain of vesicle-associated membrane protein (VAMP) 2 (also known as synaptobrevin2) contains a conserved cluster of basic/hydrophobic residues that may play an important role in membrane fusion. Our measurements on peptides corresponding to this domain determine the electrostatic and hydrophobic energies by which this domain of ...
Dumaine, Williams +4 more
openaire +2 more sources
Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation
Frontiers in Physiology, 2017 The transport of mineral ions from the enamel organ-associated blood vessels to the developing enamel crystals involves complex cargo packaging and carriage mechanisms across several cell layers, including the ameloblast layer and the stratum intermedium.
Mirali Pandya +7 more
doaj +1 more source
Synuclein Regulates Synaptic Vesicle Clustering and Docking at a Vertebrate Synapse
Frontiers in Cell and Developmental Biology, 2021 Neurotransmission relies critically on the exocytotic release of neurotransmitters from small synaptic vesicles (SVs) at the active zone. Therefore, it is essential for neurons to maintain an adequate pool of SVs clustered at synapses in order to sustain
Kaitlyn E. Fouke +7 more
doaj +1 more source
STARD3: A Swiss Army Knife for Intracellular Cholesterol Transport
Contact, 2019 Intracellular cholesterol transport is a complex process involving specific carrier proteins. Cholesterol-binding proteins, such as the lipid transfer protein steroidogenic acute regulatory-related lipid transfer domain-3 (STARD3), are implicated in ...
Laetitia Voilquin +6 more
doaj +1 more source
Mover is a homomeric phospho-protein present on synaptic vesicles.
PLoS ONE, 2013 With remarkably few exceptions, the molecules mediating synaptic vesicle exocytosis at active zones are structurally and functionally conserved between vertebrates and invertebrates. Mover was found in a yeast-2-hybrid assay using the vertebrate-specific
Saheeb Ahmed +9 more
doaj +1 more source
The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells. [PDF]
The Journal of cell biology, 1996 Insulin stimulates glucose transport in adipocytes by translocation of the glucose transporter (GLUT-4) from an intracellular site to the cell surface. We have characterized different synaptobrevin/vesicle-associated membrane protein (VAMP) homologues in adipocytes and studied their intracellular distribution with respect to GLUT-4. VAMP-1, VAMP-2, and
Martin, S. +5 more
openaire +5 more sources
Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy
Biomedicines, 2021 Diabetic retinopathy (DR) involves progressive neurovascular degeneration of the retina. Reduction in synaptic protein expression has been observed in retinas from several diabetic animal models and human retinas.
Hugo Ramos +6 more
doaj +1 more source
Characterization of VAMP2 in Schistosoma japonicum and the Evaluation of Protective Efficacy Induced by Recombinant SjVAMP2 in Mice. [PDF]
PLoS ONE, 2015 The outer-tegument membrane covering the schistosome is believed to maintain via the fusion of membranous vesicles. Fusion of biological membranes is a fundamental process in all eukaryotic cells driven by formation of trans-SNARE (soluble N ...
Qian Han +10 more
doaj +1 more source
Vesicle-associated Membrane Protein-2/Synaptobrevin Binding to Synaptotagmin I Promotes O-Glycosylation of Synaptotagmin I [PDF]
Journal of Biological Chemistry, 2002 Synaptotagmin I (Syt I), an evolutionarily conserved integral membrane protein of synaptic vesicles, is now known to regulate Ca2+-dependent neurotransmitter release. Syt I protein should undergo several post-translational modifications before maturation and subsequent functioning on synaptic vesicles (e.g.
openaire +2 more sources
Chronic Blockade of Glutamate Receptors Enhances Presynaptic Release and Downregulates the Interaction between Synaptophysin-Synaptobrevin–Vesicle-Associated Membrane Protein 2 [PDF]
The Journal of Neuroscience, 2001 During development of neuronal circuits, presynaptic and postsynaptic functions are adjusted in concert, to optimize interneuronal signaling. We have investigated whether activation of glutamate receptors affects presynaptic function during synapse formation, when constitutive synaptic vesicle recycling is downregulated.
Bacci, A +8 more
openaire +3 more sources