Results 61 to 70 of about 498,271 (378)

Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells

Diseases, 2021
Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects.
Elise Aasebø, Annette K. Brenner, Maria Hernandez-Valladares, Even Birkeland, Olav Mjaavatten, Håkon Reikvam, Frode Selheim, Frode S. Berven, Øystein Bruserud   +8 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles

Journal of Extracellular Biology
5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair. However, 5‐FU is
Shimian Qu, Hannah M. Nelson, Xiao Liu, Yu Wang, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton   +13 more
doaj   +1 more source

Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling

Frontiers in Cellular Neuroscience, 2018
Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity.
Ira Milosevic
doaj   +1 more source

Accurate determination of elastic parameters for multi-component membranes [PDF]

, 2007
Heterogeneities in the cell membrane due to coexisting lipid phases have been conjectured to play a major functional role in cell signaling and membrane trafficking.
C. Dietrich, Cornelis Storm, K. Brakke, Laurent Holtzer, M. do Carmo, M. Yanagisawa, Stefan Semrau, Thomas Schmidt, Timon Idema, W. Helfrich   +9 more
core   +3 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity

mBio, 2018
Mycobacterium tuberculosis releases membrane vesicles (MV) that modulate host immune responses and aid in iron acquisition, although they may have additional unappreciated functions.
Dylan W. White, Sarah R. Elliott, Evan Odean, Lynne T. Bemis, Anna D. Tischler   +4 more
doaj   +1 more source

Visualization of membrane loss during the shrinkage of giant vesicles under electropulsation [PDF]

, 2009
We study the effect of permeabilizing electric fields applied to two different types of giant unilamellar vesicles, the first formed from EggPC lipids and the second formed from DOPC lipids.
Abidor, Abidor, Abidor, Angelova, Antov, Barnett, Belehradek, Carvalho, Crowley, Cyril Favard, David S. Dean, Derjaguin, Dimova, Escoffre, Favard, Franc Camps i Febrer, Gabriel, Gehl, Gilbert, Glaser, Golzio, Golzio, Gothelf, Hu, Hu, Isambert, Israelachvili, Jean-Michel Escoffre, Khalifat, Kinosita, Kummrow, Leontiadou, Marie-Pierre Rols, Marszalek, Needham, Neu, Neu, Neumann, Neumann, Pasenkiewicz-Gierula, Pastushenko, Pavlin, Powell, Riske, Riske, Robello, Rodriguez, Rodriguez, Rols, Rols, Sens, Sersa, Sugàr, Tarek, Teissié, Teissié, Tekle, Thomas Portet, Tieleman, Tieleman, Tsong, Weaver, Weaver, Winterhalter, Wohlert   +64 more
core   +6 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Extracellular vesicles

GENETICS
Abstract Extracellular vesicles (EVs) encompass a diverse array of membrane-bound organelles released outside cells in response to developmental and physiological cell needs. EVs play important roles in remodeling the shape and content of differentiating cells and can rescue damaged cells from toxic or dysfunctional content. EVs can send
Juan Wang, Maureen M Barr, Ann M Wehman
openaire   +4 more sources