Results 61 to 70 of about 521,692 (352)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity

mBio, 2018
Mycobacterium tuberculosis releases membrane vesicles (MV) that modulate host immune responses and aid in iron acquisition, although they may have additional unappreciated functions.
Dylan W. White, Sarah R. Elliott, Evan Odean, Lynne T. Bemis, Anna D. Tischler   +4 more
doaj   +1 more source

Vesicle Priming in a SNAP [PDF]

Neuron, 2010
In this issue of Neuron, Burgalossi et al. investigate synaptic vesicle priming by using presynaptic Ca(2+) uncaging at a small, glutamatergic, central synapse. Combining this technique with mouse genetics, the authors demonstrate that vesicle priming during ongoing neural activity can be limited by the recycling of recently used SNARE complexes.
Müller Martin, Davis Graeme W
openaire   +3 more sources

Influence of shear flow on vesicles near a wall: a numerical study

, 2001
We describe the dynamics of three-dimensional fluid vesicles in steady shear flow in the vicinity of a wall. This is analyzed numerically at low Reynolds numbers using a boundary element method. The area-incompressible vesicle exhibits bending elasticity.
B. Lorz, C. Pozrikidis, D. Barthés-Biesel, F. Moazzam, G.I. Taylor, H.A. Stone, I. Cantat, I. Cantat, J.M. Rallison, J.R. Blake, Kai-Chien Chang, M. Kraus, M.R. Kennedy, P. Bongrand, P. Olla, P.F. Davies, R. Bruinsma, R. Lipowsky, S. Gudi, S. Ramanujan, S.R. Keller, Sreejith Sukumaran, U. Seifert, U. Seifert, Udo Seifert   +24 more
core   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Micro- and Nano-vesicles from First Trimester Human Placentae Carry Flt-1 and Levels Are Increased in Severe Preeclampsia

Frontiers in Endocrinology, 2017
Background/objectivesPreeclampsia is a life-threatening hypertensive disease affecting 3–5% of pregnancies. While the pathogenesis of preeclampsia remains unclear, it is known that placenta-derived factors trigger the disease by activating maternal ...
Mancy Tong, Qi Chen, Joanna L. James, Peter R. Stone, Lawrence W. Chamley   +4 more
doaj   +1 more source

Individual Vesicle-Vesicle and Vesicle-Planar Bilayer Fusion Events Mediated by DNA [PDF]

Biophysical Journal, 2011
We have previously reported that DNA-lipid conjugates, when inserted into lipid vesicles, can mediate interactions between vesicles such as docking and fusion∗. These DNA-mediated interactions are a model for the biological machinery (SNARE proteins) employed in synaptic vesicle fusion. We can also use DNA-lipids to build model membrane platforms, such
Bob J. Rawle, Bettina van Lengerich, Steven G. Boxer, Poul Martin Bendix, Minsub Chung   +4 more
openaire   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Tank-treading as a means of propulsion in viscous shear flows

, 2011
The use of tank-treading as a means of propulsion for microswimmers in viscous shear flows is taken into exam. We discuss the possibility that a vesicle be able to control the drift in an external shear flow, by varying locally the bending rigidity of ...
Farutin, Golestanian, Happel, Lighthill, PIERO OLLA, Subramanian   +5 more
core   +1 more source

Contrasted Reactivity to Oxygen Tensions in Frankia sp. Strain CcI3 throughout Nitrogen Fixation and Assimilation [PDF]

, 2014
Reconciling the irreconcilable is a primary struggle in aerobic nitrogen-fixing bacteria. Although nitrogenase is oxygen and reactive oxygen species-labile, oxygen tension is required to sustain respiration.
Beauchemin, Nicholas, Ghodhbane-Gtari, Faten, Gtari, Maher, Hezbri, Karima, Ktari, Amir, Sbissi, Imed, Tisa, Louis S.   +6 more
core   +4 more sources