Results 81 to 90 of about 503,736 (302)
The iTRAPs: guardians of synaptic vesicle cargo retrieval during endocytosis
Frontiers in Synaptic Neuroscience, 2016 The reformation of synaptic vesicles during endocytosis is essential for the maintenance of neurotransmission in central nerve terminals. Newly formed synaptic vesicles must be generated with the correct protein cargo in the correct stoichiometry to be ...
Sarah Louise Gordon, Michael Alan Cousin
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Vesicle movement prior to fusion with the plasma membrane.
, 2012 Vesicle movements prior to fusion with the plasma membrane were determined in 3T3-L1 adipocytes (n = 4 cells) transfected with mCherry-IRAP-pHluorin and stimulated with 100 nM insulin.aVesicle movements were scored as unknown when high local vesicle ...
E. Michael Ostap (142104) +2 more
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Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]
, 2012 Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665) +41 more
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Human Vaccines & ImmunotherapeuticsChlamydia trachomatis is an obligate intracellular pathogen responsible for the most prevalent bacterial sexually transmitted disease globally. The high prevalence of chlamydial infections underscores the urgent need for licensed and effective vaccines ...
Dung T. Huynh +6 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Energetic and Entropic Motifs in Vesicle Morphogenesis in Amphiphilic Diblock Copolymer Solutions
Colloids and InterfacesCoarse-grained molecular dynamic simulations are employed to investigate the spatiotemporal evolution of vesicles (polymersomes) via self-assembly of randomly distributed amphiphilic diblock copolymers PB-PEO (Poly(Butadiene)-b-Poly(Ethylene Oxide)) in ...
Senyuan Liu, Radhakrishna Sureshkumar
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, 2011 The flocculation of liposomes is theoretically studied. An expression for the flocculation activation energy is derived, accounting for the electrostatic and hydrophobic interactions as well as for the correlation area of floc-spots.
openaire +2 more sources
Vesicle-free transition zones, dense core vesicles, and vesicle pool redistribution contribute to synapse growth [PDF]
, 2012 textLong-term potentiation (LTP) is a widely studied cellular mechanism of learning and memory. LTP occurs at excitatory synapses on dendritic spines.
Bell, Maria Elizabeth
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