Results 101 to 110 of about 604,621 (302)

Input-Driven Tissue P Automata [PDF]

, 2018
We introduce several variants of input-driven tissue P automata where the rules to be applied only depend on the input symbol. Both strings and multisets are considered as input objects; the strings are either read from an input tape or defined by the
Alhazov, Artiom, Freund, Rudolf, Ivanov, Sergiu, Oswald, Marion, Verlan, Sergey   +4 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway

Journal of Lipid Research, 2018
HDL apoA-1-mediated cholesterol efflux pathway requires multiple cellular proteins and signal transduction processes, including adenylyl cyclase (AC)/cAMP signaling. Due to the existence of multiple transmembrane AC isoforms, it was not known how many AC
Wanze Tang, Weilie Ma, Hang Ding, Margarita Lin, Le Xiang, Guorong Lin, Zhizhen Zhang   +6 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Aggregation Behavior and Application Properties of Novel Glycosylamide Quaternary Ammonium Salts in Aqueous Solution

Molecules
Amidation of lactobionic acid with N,N-dimethylaminopropyltriamine was conducted to obtain N-(3′-dimethylaminopropyl)-lactamido-3-aminopropane (DDLPD), which was quaternized with bromoalkanes of different carbon chain lengths to synthesize double ...
Yunkai Wang, Zeyu Chen, Erzhuang Zhang, Lifei Zhi, Martino Di Serio, Guoyong Wang, Yan Wang, Xiaoming Li, Xudong Liu, Ying Huang   +9 more
doaj   +1 more source

Impermeability effects in three-dimensional vesicles

, 2004
We analyse the effects that the impermeability constraint induces on the equilibrium shapes of a three-dimensional vesicle hosting a rigid inclusion. A given alteration of the inclusion and/or vesicle parameters leads to shape modifications of different ...
Abramowitz M, Biscari P, Biscari P, Biscari P Napoli G, Dan N, Dan N, Delaunay C, Deuling H J, Dommersnes P G, Fourcade B, G Napoli, Goulian M, Helfrich W, Jülicher F, Miao L, Nielsen C, P Biscari, Pólya G, S M Canevese, Schekman R, Seifert U, Weikl T R, Wiese W, Zhong-can O-Y   +23 more
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Vesicle Morphogenesis in Amphiphilic Triblock Copolymer Solutions

Colloids and Interfaces
Coarse-grained molecular dynamics simulations are employed to investigate the spatiotemporal evolution of vesicles (polymersomes) through the self-assembly of randomly distributed amphiphilic BAB triblock copolymers with hydrophilic A and hydrophobic B ...
Senyuan Liu, Mohammad Sadegh Samie, Radhakrishna Sureshkumar   +2 more
doaj   +1 more source

Phenotypic Changes Exhibited by E. coli Cultured in Space

Frontiers in Microbiology, 2017
Bacteria will accompany humans in our exploration of space, making it of importance to study their adaptation to the microgravity environment. To investigate potential phenotypic changes for bacteria grown in space, Escherichia coli was cultured onboard ...
Luis Zea, Michael Larsen, Frederico Estante, Klaus Qvortrup, Ralf Moeller, Sílvia Dias de Oliveira, Louis Stodieck, David Klaus   +7 more
doaj   +1 more source