Results 1 to 10 of about 949,943 (203)

The LiaFSR-SpxA2 regulatory axis governs bile salt resistance and virulence in Group B Streptococcus [PDF]

Virulence
Streptococcus agalactiae, also known as Group B Streptococcus (GBS), colonizes the intestinal tract, where it must overcome bile salt-mediated membrane disruption to establish infection.
Linhong Wang, Ruoyu Li, Jianhao Lin, Fengyang Li, Yujiao Wu, Yong-An Zhang, Hui Zeng   +6 more
doaj   +2 more sources

The acidic microenvironment in the perisinusoidal space critically determines bile salt-induced activation of hepatic stellate cells [PDF]

Communications Biology
Cholestatic liver diseases, accompanied by the hepatic accumulation of bile salts, frequently lead to liver fibrosis, while underlying profibrogenic mechanisms remain incompletely understood.
Jingguo Li, Shun Yao, Sebastian Zimny, Dennis Koob, Hai Jin, Ralf Wimmer, Gerald Denk, Biguang Tuo, Simon Hohenester   +8 more
doaj   +2 more sources

Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1−/− Ldlr−/− mice [PDF]

Journal of Lipid Research
Bile salts can strongly influence energy metabolism through systemic signaling, which can be enhanced by inhibiting the hepatic bile salt transporter Na+ taurocholate cotransporting polypeptide (NTCP), thereby delaying hepatic reuptake of bile salts to ...
Begoña Porteiro, Reinout L.P. Roscam Abbing, Wietse In het Panhuis, Dirk R. de Waart, Suzanne Duijst, Isabelle Bolt, Esther W. Vogels, Johannes H.M. Levels, Laura A. Bosmans, Winnie G. Vos, Ronald P.J. Oude Elferink, Esther Lutgens, Stan F.J. van de Graaf   +12 more
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Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs [PDF]

Communications Biology
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C.
Rongji Sum, Sylvester Jian Ming Lim, Ajitha Sundaresan, Sudipta Samanta, Muthukaruppan Swaminathan, Wayne Low, Madhumitha Ayyappan, Ting Wei Lim, Marvin Dragon Choo, Gabriel Junming Huang, Ian Cheong   +10 more
doaj   +2 more sources

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

JHEP Reports, 2022
Background & Aims: Non-absorbable inhibitors of the apical sodium-dependent bile acid transporter (ASBT; also called ileal bile acid transporter [IBAT]) are recently approved or in clinical development for multiple cholestatic liver disorders and ...
Roni F. Kunst, Dirk R. de Waart, Frank Wolters, Suzanne Duijst, Esther W. Vogels, Isabelle Bolt, Joanne Verheij, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +9 more
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Comparative Genomic Analysis Determines the Functional Genes Related to Bile Salt Resistance in Lactobacillus salivarius

Microorganisms, 2021
Lactobacillus salivarius has drawn attention because of its promising probiotic functions. Tolerance to the gastrointestinal tract condition is crucial for orally administrated probiotics to exert their functions.
Qiqi Pan, Xudan Shen, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai   +7 more
doaj   +1 more source

New Kids on the Block: Bile Salt Conjugates of Microbial Origin

Metabolites, 2022
Biotransformation of host bile salts by gut microbes results in generation of secondary bile salt species that have biological and physicochemical properties that are distinct from the parent compounds.
Ümran Ay, Martin Leníček, Arno Classen, Steven W. M. Olde Damink, Carsten Bolm, Frank G. Schaap   +5 more
doaj   +1 more source

Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration

Hepatology Communications, 2021
The involvement of bile salt–fibroblast growth factor 19 (FGF19) signaling in human liver regeneration (LR) is not well studied. Therefore, we studied aspects of bile salt–FGF19 signaling shortly after liver resection in patients. We compared plasma bile
Kiran V.K. Koelfat, Kim M.C. vanMierlo, Toine M. Lodewick, Johanne G. Bloemen, Gregory van derKroft, Iakovos Amygdalos, Ulf P. Neumann, Cornelis H.C. Dejong, Peter L.M. Jansen, Steven W.M. Olde Damink, Frank G. Schaap   +10 more
doaj   +1 more source

The economy of the enterohepatic circulation of bile acids in the baboon. 1. Studies of controlled enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
A primate model with controlled enterohepatic circulation has been developed which allowed short-term evaluation of bile salt pool size, cycling frequency, and fecal losses.
R N Redinger, J W Hawkins, D M Grace
doaj   +1 more source

A new insight into the physiological role of bile salt hydrolase among intestinal bacteria from the genus Bifidobacterium. [PDF]

PLoS ONE, 2014
This study analyzes the occurrence of bile salt hydrolase in fourteen strains belonging to the genus Bifidobacterium. Deconjugation activity was detected using a plate test, two-step enzymatic reaction and activity staining on a native polyacrylamide gel.
Piotr Jarocki, Marcin Podleśny, Paweł Glibowski, Zdzisław Targoński   +3 more
doaj   +1 more source