Results 41 to 50 of about 59,410 (160)

Cholesterol Solubilization by Solutions of Bile Salts and Bile Salts Plus Lecithin

Experimental Biology and Medicine, 1968
SummaryModel synthetic solutions were used to study cholesterol solubilization by the 6 conjugated bile salts found in human bile individually and as a mixture, and by lecithin in combination with bile salts. In the range of concentrations found in bile, bile salts alone solubilized only about one third as much cholesterol as might be found in ...
D H, Neiderhiser, H P, Roth
openaire   +2 more sources

Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice

JHEP Reports
Background & Aims: Intestine-restricted inhibitors of the apical sodium-dependent bile acid transporter (ASBT, or ileal bile acid transporter) are approved as treatment for several inheritable forms of cholestasis but are also associated with ...
Roni F. Kunst, Isabelle Bolt, Rychon D.J. van Dasselaar, Bart A. Nijmeijer, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +6 more
doaj   +1 more source

Method for removal of surface-active impurities and calcium from conjugated bile salt preparations: comparison with silicic acid chromatography.

Journal of Lipid Research, 1995
Some commercial preparations of common natural conjugated bile salts contain impurities (e.g., amines, lipids, and calcium) that are likely to affect their physicochemical properties. A method was developed for purifying commercial preparations of sodium
S. Del Vecchio, J.D. Ostrow, P. Mukerjee, H.T. Ton-Nu, C.D. Schteingart, A.F. Hofmann, C. Cerrè, A. Roda   +7 more
doaj   +1 more source

Immobilized artificial membrane chromatography: a rapid and accurate HPLC method for predicting bile salt-membrane interactions.

Journal of Lipid Research, 1996
To predict bile salt-membrane interactions physiologically, we used an immobilized artificial membrane HPLC column that contains dimyristoyl-phosphatidylcholine molecules covalently linked to silica microspheres.
D E Cohen, M R Leonard
doaj   +1 more source

Mechanistic insights into the inhibition of NTCP by myrcludex B

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Joanne M. Donkers, Monique D. Appelman, Stan F.J. van de Graaf   +2 more
doaj   +1 more source

The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities.

Journal of Lipid Research, 1982
To examine quantitatively the hydrophobic-hydrophilic properties of bile salts, we determined the reverse-phase high performance liquid chromatographic (HPLC) mobilities of monomeric bile salt solutions and the equilibrium cholesterol-solubilizing ...
M J Armstrong, M C Carey
doaj   +1 more source

Mathematical model of biliary lipid secretion: a quantitative analysis of physiological and biochemical data from man and other species.

Journal of Lipid Research, 1984
We propose a simple mathematical model to account for the coupling of secretion rates of bile salts, lecithin, and cholesterol into bile. The model assumes that: 1) molecules of ''biliary'' lecithin and cholesterol enter a functional compartment located ...
N A Mazer, M C Carey
doaj   +1 more source

Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.

Journal of Lipid Research, 1988
The role of the hepatocyte microtubular system in the transport and excretion of bile salts and biliary lipid has not been defined. In this study the effects of microtubule inhibition on biliary excretion of micelle- and non-micelle-forming bile salts ...
J M Crawford, C A Berken, J L Gollan
doaj   +1 more source

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

Journal of Lipid Research, 2007
The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.
Henkjan J. Verkade, Rick Havinga, David J. Shields, Henk Wolters, Vincent W. Bloks, Folkert Kuipers, Dennis E. Vance, Luis B. Agellon   +7 more
doaj   +1 more source

Hepatic Transport of Bile Salts

Seminars in Liver Disease, 2000
The vectorial secretion of bile salts from blood into bile is a major driving force for bile formation. The basolateral hepatocyte membrane extracts bile salts from sinusoidal blood via Na(+)-dependent and Na(+)-independent membrane transporters. Na(+)-dependent uptake of bile salts is mediated by the Na(+)-taurocholate co-transporting polypeptide, a ...
Kullak-Ublick, G. A., Stieger, B., Hagenbuch, B., Meier, P. J.   +3 more
openaire   +3 more sources