Results 51 to 60 of about 949,943 (203)

Metagenomic analysis of bile salt biotransformation in the human gut microbiome

BMC Genomics, 2019
Background In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human ...
Promi Das, Simonas Marcišauskas, Boyang Ji, Jens Nielsen   +3 more
doaj   +1 more source

Cholesterol Solubilization by Solutions of Bile Salts and Bile Salts Plus Lecithin

Experimental Biology and Medicine, 1968
SummaryModel synthetic solutions were used to study cholesterol solubilization by the 6 conjugated bile salts found in human bile individually and as a mixture, and by lecithin in combination with bile salts. In the range of concentrations found in bile, bile salts alone solubilized only about one third as much cholesterol as might be found in ...
D H, Neiderhiser, H P, Roth
openaire   +2 more sources

Relation of Gallbladder Motility to Viscosity and Composition of Gallbladder Bile in Patients with Cholesterol Gallstones [PDF]

, 2009
Background/Aims: Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones.
Straub, Gundula, Juengst, Christoph, Schneider, Berthold, del Pozo, Reginald, Juengst, Dieter, Neubrand, Michael, Spelsberg, Fritz W., Althaus, Rupert, Gruendel, Denis, Huettl, Thomas P.   +9 more
core   +1 more source

Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice

JHEP Reports
Background & Aims: Intestine-restricted inhibitors of the apical sodium-dependent bile acid transporter (ASBT, or ileal bile acid transporter) are approved as treatment for several inheritable forms of cholestasis but are also associated with ...
Roni F. Kunst, Isabelle Bolt, Rychon D.J. van Dasselaar, Bart A. Nijmeijer, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf   +6 more
doaj   +1 more source

The sodium bile salt cotransport family SLC10 [PDF]

, 2004
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known.
Dawson, Paul, Hagenbuch, Bruno
core   +1 more source

Method for removal of surface-active impurities and calcium from conjugated bile salt preparations: comparison with silicic acid chromatography.

Journal of Lipid Research, 1995
Some commercial preparations of common natural conjugated bile salts contain impurities (e.g., amines, lipids, and calcium) that are likely to affect their physicochemical properties. A method was developed for purifying commercial preparations of sodium
S. Del Vecchio, J.D. Ostrow, P. Mukerjee, H.T. Ton-Nu, C.D. Schteingart, A.F. Hofmann, C. Cerrè, A. Roda   +7 more
doaj   +1 more source

Immobilized artificial membrane chromatography: a rapid and accurate HPLC method for predicting bile salt-membrane interactions.

Journal of Lipid Research, 1996
To predict bile salt-membrane interactions physiologically, we used an immobilized artificial membrane HPLC column that contains dimyristoyl-phosphatidylcholine molecules covalently linked to silica microspheres.
D E Cohen, M R Leonard
doaj   +1 more source

Bile salt‐stimulated lipase in human milk

, 1993
Human milk bile salt-stimulated lipase ensures efficient triacylglycerol utilization in breast-fed newborns. For activity against long-chain triacylglycerol, primary bile salts are a prerequisite.
Olle Hernell, Lars Bläckberg, Hernell, Olle,, Bläckberg, Lars,   +3 more
core   +1 more source

Determinants of bile secretion: effect of bile salt structure on bile flow and biliary cation secretion

, 1989
The effect of five bile salts, deoxycholate, chenodeoxycholate, cholate, ursodeoxycholate, and ursocholate, possessing (in decreasing order) different hydrophobicity, on bile flow and biliary secretion of total calcium, magnesium, sodium, and potassium ...
LORIA, Paola, MEDICI G., TRIPODI A., IORI R., ROMANI M., CARULLI, Nicola, ROSI A., BERGOMI, Margherita, ROVESTI, Sergio   +8 more
core   +1 more source

Comparative genomics of lactic acid bacteria reveals a niche-specific gene set [PDF]

, 2009
peer-reviewedBackground: The recently sequenced genome of Lactobacillus helveticus DPC4571 1 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM 2. This led us to hypothesise that
O\u27Callaghan, John, Callanan, Michael J., Fitzgerald, Gerald F, Gerald F Fitzgerald, Sangrador-Vegas, Amaia, Kaleta Pawel, O'Callaghan John, O'Sullivan, Orla, Fitzgerald Gerald F, Callanan Michael, O\u27Sullivan, Orla, Ross, R. Paul, Fitzgerald, Gerald F., Michael Callanan, O'Callaghan, John, Tom Beresford, Orla O'Sullivan, O'Sullivan Orla, Beresford, Thomas P., John O'Callaghan, Ross R Paul, Kaleta, Pawel, McAuliffe Olivia, Beresford, Tom, Olivia McAuliffe, Lydia Slattery, Amaia Sangrador-Vegas, McAuliffe, Olivia, Slattery Lydia, Pawel Kaleta, R Paul Ross, Slattery, Lydia, Beresford Tom, Ross, R Paul, Callanan, Michael, Sangrador-Vegas Amaia, O'Sullivan, Orla, O'Callaghan, John   +37 more
core   +1 more source