Results 91 to 100 of about 503,736 (302)

Vesicle Geometries Enabled by Semiflexible Polymer

, 2022
Understanding and controlling vesicle shapes is fundamental challenge in biophysics and materials design. In this paper, we employ the Monte Carlo method to investigate the shape of soft vesicle induced by semiflexible polymer outside in two dimensions ...
Aihua Chai, Zhiyong Yang, Shuiping Luo, Ping Li, Dan Lu, Nianqiang Kang   +5 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds

EXCLI Journal : Experimental and Clinical Sciences
Niosomes are drug delivery systems with widespread applications in pharmaceutical research and the cosmetic industry. Niosomes are vesicles of one or more bilayers made of non-ionic surfactants, cholesterol, and charge inducers.
Mohammad Saleh Fadaei, Mohammad Reza Fadaei, Amir Emad Kheirieh, Pouria Rahmanian-Devin, Mohammad Mahdi Dabbaghi, Kiarash Nazari Tavallaei, Abouzar Shafaghi, Hooman Hatami, Vafa Baradaran Rahimi, Ali Nokhodchi, Vahid Reza Askari   +10 more
doaj   +1 more source

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

Frontiers in Cellular Neuroscience, 2019
Previous studies have demonstrated that T cells and microglia could fight against cerebral Listeria monocytogenes (Listeria); however, their synergistic anti-Listeria mechanisms remain unknown.
Chao Wang, Yang Wang, Xiaochen Shi, Xudong Tang, Wei Cheng, Xueyan Wang, Yanan An, Shulin Li, Hongyue Xu, Yan Li, Wenjing Luan, Xuefei Wang, Zhaobin Chen, Zhaobin Chen, Mingyuan Liu, Mingyuan Liu, Lu Yu   +16 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Synaptic vesicles are primed for fast clathrin-mediated endocytosis at the ribbon synapse

Frontiers in Molecular Neuroscience, 2014
Retrieval of synaptic vesicles can occur 1-10 s after fusion, but the role of clathrin during this process has been unclear because the classical mode of clathrin-mediated endocytosis (CME) is an order of magnitude slower, as during retrieval of surface ...
Ilaria ePelassa, Ilaria ePelassa, CongJian eZhao, CongJian eZhao, Mathias ePasche, Benjamin eOdermatt, Benjamin eOdermatt, Leon eLagnado, Leon eLagnado   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway

Journal of Lipid Research, 2018
HDL apoA-1-mediated cholesterol efflux pathway requires multiple cellular proteins and signal transduction processes, including adenylyl cyclase (AC)/cAMP signaling. Due to the existence of multiple transmembrane AC isoforms, it was not known how many AC
Wanze Tang, Weilie Ma, Hang Ding, Margarita Lin, Le Xiang, Guorong Lin, Zhizhen Zhang   +6 more
doaj   +1 more source