Results 81 to 90 of about 498,271 (378)
Vesicle Priming in a SNAP [PDF]
Neuron, 2010 In this issue of Neuron, Burgalossi et al. investigate synaptic vesicle priming by using presynaptic Ca(2+) uncaging at a small, glutamatergic, central synapse. Combining this technique with mouse genetics, the authors demonstrate that vesicle priming during ongoing neural activity can be limited by the recycling of recently used SNARE complexes.
Müller Martin, Davis Graeme W
openaire +3 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Dynamics of Three-Dimensional Vesicles in DC Electric fields [PDF]
, 2015 A numerical and systematic parameter study of three-dimensional vesicle electrohydrodynamics is presented to investigate the effects of different fluid and membrane properties. The dynamics of vesicles in the presence of DC electric fields is considered, both in the presence and absence of linear shear flow.
arxiv +1 more source
Morphology of axisymmetric vesicles with encapsulated filaments and impurities
, 2002 The shape deformation of a three-dimensional axisymmetric vesicle with encapsulated filaments or impurities is analyzed by integrating a dissipation dynamics.
Allan D. +19 more
core +1 more source
Individual Vesicle-Vesicle and Vesicle-Planar Bilayer Fusion Events Mediated by DNA [PDF]
Biophysical Journal, 2011 We have previously reported that DNA-lipid conjugates, when inserted into lipid vesicles, can mediate interactions between vesicles such as docking and fusion∗. These DNA-mediated interactions are a model for the biological machinery (SNARE proteins) employed in synaptic vesicle fusion. We can also use DNA-lipids to build model membrane platforms, such
Bob J. Rawle +4 more
openaire +2 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Journal of Systems Chemistry, 2011 While studying fatty acid vesicles as model primitive cell membranes, we encountered a dramatic phenomenon in which light triggers the sudden rupture of micron-scale dye-containing vesicles, resulting in rapid release of vesicle contents. We show that such vesicle explosions are caused by an increase in internal osmotic pressure mediated by the ...
Ting F. Zhu, Jack W. Szostak
openaire +2 more sources
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Shape deformation of a vesicle under axisymmetric non-uniform alternating electric field [PDF]
, 2018 Non-uniform fields are commonly used to study vesicle dielectrophoresis and can be used to hitherto relatively unexplored areas of vesicle deformation and electroporation. A common but perplexing problem in vesicle dynamics is the cross over from the entropic to enthalpic (stretching) tension during vesicle deformation.
arxiv +1 more source
Contrasted Reactivity to Oxygen Tensions in Frankia sp. Strain CcI3 throughout Nitrogen Fixation and Assimilation [PDF]
, 2014 Reconciling the irreconcilable is a primary struggle in aerobic nitrogen-fixing bacteria. Although nitrogenase is oxygen and reactive oxygen species-labile, oxygen tension is required to sustain respiration.
Beauchemin, Nicholas +6 more
core +4 more sources