Results 81 to 90 of about 152,465 (288)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation
Cells, 2020 Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport.
Anna Frappaolo +3 more
doaj +1 more source
Molecular Mechanisms of Secreting Vesicle Biogenesis and Secretion in Chronic Degenerative Diseases [PDF]
, 2012 Regulated trafficking and secretion of insulin by the β cell of the endocrine pancreas is critical to maintain our body energy homeostasis. Disruption of these processes typically leads to hyperglycemia and the complications of diabetes.
Qiao, Xinxian
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The WDR11 complex facilitates the tethering of AP-1-derived vesicles
Nature Communications, 2018 Trafficking from endosomes to the trans-Golgi network requires recognition of vesicle tethers during membrane docking. Here, the authors identify a complex localised to AP-1 generated vesicles containing WDR11, C17orf75 and FAM91A, which together with ...
Paloma Navarro Negredo +4 more
doaj +1 more source
The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
Biochemistry Research International, 2020 Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking.
Wanqiong Yuan, Chunli Song
doaj +1 more source
GhRabA4c coordinates cell elongation via regulating actin filament–dependent vesicle transport
Life Science Alliance, 2022 GhRabA4c is required for cotton fiber cell elongation via functioning in actin filament assembly and bundling, vesicle transport, and deposition of multiple cell wall components. Plant cell expands via a tip growth or diffuse growth mode. In plants, RabA
Xiaoguang Shang +10 more
doaj +1 more source
Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. [PDF]
, 2015 Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease.
Goldstein, Lawrence SB +2 more
core +1 more source
LRRK2: A Problem Lurking in Vesicle Trafficking? [PDF]
Journal of Neuroscience, 2011 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the major genetic cause of Parkinson's disease (PD), accounting for ∼5% of familial and 0.5–2% of sporadic cases ([Dachsel and Farrer, 2010][1]).
Sybille, Dihanich, Claudia, Manzoni
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source