Results 21 to 30 of about 478,651 (249)

Study of Physico-Chemical Properties and Morphology of Phospholipid Composition of Indomethacin

Nanomaterials, 2022
Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of cyclooxygenase-2, an enzyme involved in the formation of anti-inflammatory prostaglandin PGE2, are the most common treatment for chronic inflammatory diseases, such as, for example, arthritis ...
Elena G. Tikhonova, Yulia A. Tereshkina, Lyubov V. Kostryukova, Yulia Yu. Khudoklinova, Maxim A. Sanzhakov, Anna O. Tamarovskaya, Oleksandr I. Ivankov, Mikhail A. Kiselev   +7 more
doaj   +1 more source

Extracellular Vesicles Mediate Epimastigogenesis in Trypanosoma cruzi: Strain-Specific Dynamics and Temperature-Dependent Differentiation

Life
Trypanosoma cruzi, the causative agent of Chagas disease, undergoes epimastigogenesis—a critical differentiation step in which trypomastigotes transform into epimastigotes. While this process is essential for the parasite’s survival in its insect vector,
Abel Sana, Izadora Volpato Rossi, Bruna Sabatke, Marcel Ivan Ramirez   +3 more
doaj   +1 more source

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +1 more source

LIPOSOMES AND NANOSOMES: STRUCTURE, PROPERTIES, PRODUCTION [PDF]

Biotechnologia Acta, 2013
Liposomes are hollow particles which content is limited to a lipid membrane. They belong to a large family of vesicular (bubble) structures formed by amphiphilic molecules. Liposomes consisting of one or more phospholipid bilayers were first described in
S. M. Shulga
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Scientific Reports
Traditional investigations of viral infection mechanisms have predominantly relied on two-dimensional (2D) cell culture models, which lack the structural organization and physiological relevance of native tissues.
Yi-Wen Chen, Huan-Jung Chiang, Kuan-Ting Liu, Chun-Wei Kao, Shan-Ren Xie, Chao-Ming Su, Yu-Yin Shih   +6 more
doaj   +1 more source

The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson’s disease

Frontiers in Cellular Neuroscience
Parkinson’s disease is a pathology with a wide range of in vivo and in vitro models available. Among these, the SH-SY5Y neuroblastoma cell line is one of the most employed.
Angel Carvajal-Oliveros, Camila Román-Martínez, Enrique Reynaud, Eduardo Martínez-Martínez   +3 more
doaj   +1 more source

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

Viruses, 2016
The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the plasma membrane.
Inés Romero-Brey, Ralf Bartenschlager
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source