Results 101 to 110 of about 146,054 (301)

Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry

Journal of Neuroscience, 2013
The use of neurotropic viruses as transsynaptic tracers was first described in the 1960s, but only recently have such viruses gained popularity as a method for labeling neural circuits.
Kevin T. Beier, B. Borghuis, R. El-Danaf, A. Huberman, J. Demb, C. Cepko   +5 more
semanticscholar   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch [PDF]

, 2010
The bacterial flagellar switch that controls the direction of flagellar rotation during chemotaxis has a highly cooperative response. This has previously been understood in terms of the classic two-state, concerted model of allosteric regulation.
F. Bai, R. W. Branch, D. V. Nicolau, T. Pilizota, B. C. Steel, P. K. Maini, R. M. Berry, Monod, Duke, Duke, Changeux, Sowa, Cluzel, Bray, Turner, Alon, Kudo, Block, Scharf, Korobkova, Sowa, Ryu, Korobkova, Lapidus, Block, van Albada, Yuan, Karpen, Dyer, Van Way   +29 more
core   +3 more sources

Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein

Nature Communications, 2018
Glycoprotein G of vesicular stomatitis virus (VSV) enables viral entry by binding to the major VSV receptor LDL-R. Here the authors present crystal structures of G in complex with two distinct CR domains of LDL-R, identifying structural determinants for ...
Jovan Nikolic, Laura Belot, Hélène Raux, Pierre Legrand, Yves Gaudin, Aurélie A. Albertini   +5 more
doaj   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Low‐Background His‐Tag‐Targeting Probes for Turn‐On Fluorescence Detection of Cell Surface Proteins and Their Binding Interactions

Small, EarlyView.
Conjugating a tri‐nitrilotriacetic acid unit to quinoline‐based cyanine dyes generated probes that fluoresce upon binding to His‐tagged proteins on cell surfaces. Using the thiazole orange‐bearing probe, the binding of the receptor binding domain (RBD) of the SARS‐CoV‐2 virus to host cells is readily detected, enabling the straightforward ...
Pragati Kishore Prasad, Suraj Toraskar, Suman Khan, Tom Granot, Yael Fridmann Sirkis, Eliane Hadas Yardeni, Shira Albeck, Tamar Unger, Ekaterina Petrovich‐Kopitman, Yoseph Addadi, Rakesh Raigawali, Saurabh Anand, Sharath S. Vishweshwara, Chethan D. Shanthamurthy, Noa Oppenheimer‐Low, Raghavendra Kikkeri, Ori Avinoam, Leila Motiei, David Margulies   +18 more
wiley   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B., Dong, C., Dong, H., Elliott, R., Li, P.   +4 more
core   +1 more source

Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

Emerging Infectious Diseases, 2015
The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs.
Emmie de Wit, Andrea Marzi, Trenton Bushmaker, Doug Brining, Dana Scott, Juergen A. Richt, Thomas W. Geisbert, Heinz Feldmann   +7 more
doaj   +1 more source

Mapping the Interface between New World Hantaviruses and Their Receptor, PCDH1

Proceedings, 2020
Hantaviruses are found throughout the world and can cause deadly diseases in humans, specifically, hantavirus cardiopulmonary syndrome (HCPS) in the New World and hemorrhagic fever with renal syndrome (HFRS) in the Old World.
Megan M. Slough, Andrew S. Herbert, Ana I. Kuehne, John M. Dye, Kartik Chandran, Rohit K. Jangra   +5 more
doaj   +1 more source

Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes

Small Methods, EarlyView.
This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang, Taesoo Kim, Su‐jin Hong, Se‐yeon Kim, Hyeseung Hwang, Siwon Kim, Su‐a Kang, Nabin Won, Dogeun Kim, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Kyubong Jo, Kwang‐il Lim   +13 more
wiley   +1 more source