Results 71 to 80 of about 66,107 (232)

Targeted siRNA Delivery Using Cetuximab‐Conjugated Starch for Epidermal Growth Factor Receptor‐Driven Head and Neck Squamous Cell Carcinoma

Small Science, EarlyView.
A starch‐based carrier conjugated to cetuximab enables targeted siRNA delivery to epidermal growth factor receptor‐overexpressing tumors. The complexes exhibit dual passive and active tumor targeting, effective cellular uptake, and gene silencing, offering a versatile platform for RNA therapeutics in head and neck cancer.
Chen Benafsha, Limor Cohen, Leah Shimonov, Riki Goldbart, Tamar Traitel, Eliz Amar‐Lewis, Ramesh Chintakunta, Manu Parasad, Uzi Hadad, Moshe Elkabets, Joseph Kost   +10 more
wiley   +1 more source

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Ohba, Tomoyuki, Schirmer, Eric C   +3 more
core   +2 more sources

Untargeted Lipidomics of Vesicular Stomatitis Virus-Infected Cells and Viral Particles

Viruses, 2021
The viral lifecycle is critically dependent upon host lipids. Enveloped viral entry requires fusion between viral and cellular membranes. Once an infection has occurred, viruses may rely on host lipids for replication and egress.
Katherine E. Havranek, Judith Mary Reyes Ballista, Kelly Marie Hines, Melinda Ann Brindley   +3 more
doaj   +1 more source

Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes

Small Methods, EarlyView.
This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang, Taesoo Kim, Su‐jin Hong, Se‐yeon Kim, Hyeseung Hwang, Siwon Kim, Su‐a Kang, Nabin Won, Dogeun Kim, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Kyubong Jo, Kwang‐il Lim   +13 more
wiley   +1 more source

Nonlinearities of Penman and Penman-Monteith Equations across Multiple Timescales [PDF]

arXiv, 2023
The nonlinear Penman and Penman-Monteith equations, widely used for estimating surface evapotranspiration at regional and global scales, were derived from turbulent transport of heat fluxes and thus apply to subhourly scale. However, these equations have been directly applied with hydrometeorological variables averaged at longer time intervals, leading
arxiv  

When does vapor pressure deficit drive or reduce evapotranspiration? [PDF]

Journal of Advances in Modeling Earth Systems, 11. (2019), 2018
Increasing vapor pressure deficit (VPD) increases atmospheric demand for water. While increased evapotranspiration (ET) in response to increased atmospheric demand seems intuitive, plants are capable of reducing ET in response to increased VPD by closing their stomata. We examine which effect dominates the response to increasing VPD: atmospheric demand
arxiv   +1 more source

p53 Deficiency in Colon Cancer Cells Promotes Tumor Progression Through the Modulation of Meflin in Fibroblasts

Cancer Science, EarlyView.
TP53 deficiency in colon cancer cells suppresses Meflin expression in fibroblasts and promotes fibroblast‐mediated tumor growth. Suppression of Meflin expression could transform normal fibroblasts into ones exhibiting a CAF‐like phenotype, promoting colon cancer cell growth.
Eiji Kimura, Yoshito Hayashi, Kentaro Nakagawa, Hirotsugu Saiki, Minoru Kato, Ryotaro Uema, Takanori Inoue, Takeo Yoshihara, Akihiko Sakatani, Hiromu Fukuda, Ayaka Tajiri, Yujiro Adachi, Kazuhiro Murai, Shunsuke Yoshii, Yoshiki Tsujii, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara   +17 more
wiley   +1 more source

In Vitro Expansion and Transduction of Primary NK Cells Using Feeder Cells Expressing Costimulatory Molecules and IL‐21

Cancer Science, EarlyView.
Our findings show that feeder cells expressing CD80, 41BBL and membrane‐bound IL‐21 promote optimal NK cell expansion. We also evaluated CAR transduction efficiency into expanded NK cells using different lentiviral vectors. The results indicate that NK cells transduced with the BaeV lentivirus exhibit high cytotoxicity toward target cells.
Thi Bao Tram Tran, Thi Van Anh Bui, Thi Minh Thu Tran, Nguyen Minh Nguyen, Hoang Thien Phuc Nguyen, Thi Phuong Diem Tran, Duc Minh Quan Nguyen, Thai Minh Quan Ngo, Thanh Binh Nguyen, Els Verhoeyen, Nhat Thang Tran, Hoai‐Nghia Nguyen, Le Son Tran   +12 more
wiley   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B., Dong, C., Dong, H., Elliott, R., Li, P.   +4 more
core   +1 more source

Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines

Emerging Infectious Diseases, 2019
Use of the vesicular stomatitis virus (VSV)–based Ebola virus vaccine during outbreaks and the potential use of a similar VSV-based Lassa virus vaccine has raised questions about the vaccines’ stability should the cold chain fail.
Derek R. Stein, Patrycja Sroga, Bryce M. Warner, Yvon Deschambault, Guillaume Poliquin, David Safronetz   +5 more
doaj   +1 more source