Results 81 to 90 of about 83,942 (295)

"In vitro" reconstitution of "trans"-Golgi exit and the effect of GAG attachment on protein sorting [PDF]

, 2007
The trans-Golgi network is one of the main sorting stations for proteins and lipids in the eukaryotic endomembrane system. Yet, the mechanisms for sorting and transport out of the trans-Golgi network remain poorly understood.
Kobialka, Szymon
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg

Microbial Cell, 2019
Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility.
Joana N. Bugalhão, Luís Jaime Mota
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Rab8a/SNARE complex activation promotes vesicle anchoring and transport in spinal astrocytes to drive neuropathic pain

Biomolecules & Biomedicine
Neuropathic pain (NPP) remains a clinically challenging condition, driven by the activation of spinal astrocytes and the complex release of inflammatory mediators.
Yunqiao Xiao, Gengyi Wang, Guiqiong He, Wanxiang Qin, Ying Shi   +4 more
doaj   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

RETRACTED: Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer

eLife, 2019
Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with Leptospira-containing animal urine-contaminated water.
Yang Li, Kai-Xuan Li, Wei-Lin Hu, David M Ojcius, Jia-Qi Fang, Shi-Jun Li, Xu'ai Lin, Jie Yan   +7 more
doaj   +1 more source

Signal peptide peptidase‐like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins [PDF]

, 2019
Members of the GxGD-type intramembrane aspartyl proteases have emerged as key players not only in fundamental cellular processes such as B-cell development or protein glycosylation, but also in development of pathologies, such as Alzheimer's disease or ...
Torben Mentrup, Mentrup, T., Bernd Schröder, Regina Fluhrer, Schröder, Bernd, Mayerhofer, Artur, Schroeder, B., Fluhrer, R., Alkmini A Papadopoulou, Mueller, S., Martina Haug‐Kröper, Haug-Kroeper, Martina, Lichtenthaler, Stefan F., Müller, Stephan A., Niemeyer, J., Mayerhofer, A., Shmueli, M., Haug‐Kröper, Martina, Regina Feederle, Niemeyer, Johannes, Artur Mayerhofer, Haug-Kroeper, M., von Blume, J., Mentrup, Torben, Papadopoulou, A., Fluhrer, Regina, Feederle, Regina, Stefan F Lichtenthaler, Shmueli, Merav D., Stephan A Müller, Müller, Stephan A, Papadopoulou, Alkmini A., Johannes Niemeyer, Feederle, R., von Blume, Julia, Blume, Julia von, Shmueli, Merav D, Lichtenthaler, S., Merav D Shmueli, Julia von Blume   +39 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

Advanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk, Eylul Gulsen Yilmaz, Yusuf Aslan, Emre Ece, Özgecan Erdem, Murat Alp Gungen, Bengi Özgün Öztürk, Fatih Inci   +7 more
wiley   +1 more source