Results 61 to 70 of about 83,942 (295)

Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast [PDF]

, 2014
Lipids synthesized at the endoplasmic reticulum (ER) are delivered to the Golgi by vesicular and non-vesicular pathways. ER-to-Golgi transport is crucial for maintaining the different membrane lipid composition and identities of organelles. Despite their
Funato, Kouichi, Muñiz Guinea, Manuel, Aguilera Romero, María Auxiliadora, Castillon, Guillaume Alain, Ikeda, Atsuko, Kajiwara, Kentaro, Kagiwada, Satoshi   +6 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Sphingolipid Metabolism at the ER-Golgi Contact Zone and Its Impact on Membrane Trafficking

Contact, 2020
Proteins and lipids represent the two major constituents of biological membranes. Different organelles have different lipid compositions, which may be crucial for the execution and control of various organelle-specific functions.
Asako Goto, Aya Mizuike, Kentaro Hanada
doaj   +1 more source

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]

, 2012
Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P., Coley, Helen M., Neves, V, Flahaut, E, Gerondopoulos, Andreas, Heister, Elena, Neves, Vera, Tîlmaciu, Carmen, Coley, HM, Flahaut, Emmanuel, Gerondopoulos, A, Heister, E, McFadden, J, McFadden, Johnjoe, Soula, Brigitte, Soula, B, Tîlmaciu, C, Silva, SRP   +17 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Ca2+-independent phospholipase A2 participates in the vesicular transport of milk proteins

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
Changes in the lipid composition of intracellular membranes are believed to take part in the molecular processes that sustain traffic between organelles of the endocytic and exocytic transport pathways. Here, we investigated the participation of the calcium-independent phospholipase A2 in the secretory pathway of mammary epithelial cells.
Péchoux, Christine, Boisgard, R., Chanat, Eric, Lavialle, F.   +3 more
openaire   +2 more sources

Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. [PDF]

Proceedings of the National Academy of Sciences, 1988
N-Ethylmaleimide (NEM) inhibits protein transport between successive compartments of the Golgi stack in a cell-free system. After inactivation of the Golgi membranes by NEM, transport can be rescued by adding back an appropriately prepared cytosol fraction. This complementation assay has allowed us to purify the NEM-sensitive factor, which we term NSF.
M R, Block, B S, Glick, C A, Wilcox, F T, Wieland, J E, Rothman   +4 more
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Virus infection and vesicle trafficking

Frontiers in Immunology
Vesicle trafficking mechanisms play indispensable roles throughout the viral replication cycle, though their stage-specific regulatory mechanisms during infection require further elucidation.
Guo-Xiu Cao, Fan-Xin Liu, Chun-Chun Meng, Chan Ding, Jun Dai, Xu-Sheng Qiu   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source