Results 51 to 60 of about 83,942 (295)

Molecular mechanisms of Sar/Arf GTPases in vesicular trafficking in yeast and plants

Frontiers in Plant Science, 2014
Small GTPase proteins play essential roles in the regulation of vesicular trafficking systems in eukaryotic cells. Two types of small GTPases, secretion-associated Ras-related protein (Sar) and ADP-ribosylation factor (Arf), act in the biogenesis of ...
Tomohiro eYorimitsu, Ken eSato, Masaki eTakeuchi   +2 more
doaj   +1 more source

GLTP mediated non-vesicular GM1 transport between native membranes. [PDF]

PLoS ONE, 2013
Lipid transfer proteins (LTPs) are emerging as key players in lipid homeostasis by mediating non-vesicular transport steps between two membrane surfaces. Little is known about the driving force that governs the direction of transport in cells.
Ines Lauria, Jan van Üüm, Esmina Mjumjunov-Crncevic, David Walrafen, Luis Spitta, Christoph Thiele, Thorsten Lang   +6 more
doaj   +1 more source

A Review Study of the Participation of Late Domains in Sorting and Transport of Viral Factors to Exosomes

Life, 2023
Cellular communication depends heavily on the participation of vesicular systems generated by most cells of an organism. Exosomes play central roles in this process. Today, these vesicles have been characterized, and it has been determined that the cargo
Manuel Adrián Velázquez-Cervantes, Yazmín Rocío Benítez-Zeferino, Arturo Flores-Pliego, Addy Cecilia Helguera-Repetto, David Eduardo Meza-Sánchez, José Luis Maravillas-Montero, Guadalupe León-Reyes, Javier Mancilla-Ramírez, Jorge Francisco Cerna-Cortés, María Isabel Baeza-Ramírez, Moises León-Juaárez   +10 more
doaj   +1 more source

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]

, 2011
Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Tatu, Utpal, Yera, H., Yera, Helene, Talabani, Hana, Talabani, H., Dandavate, V., Dandavate, Vrushali, Langsley, Gordon, Tatu, U., Langsley, G., Bourdoncle, P., Meissner, M., Ben Rached, Fathia, Ndjembo-Ezougou, Carinne, Rached, F.B., Chandran, S., Chandran, Syama, Ndjembo-Ezougou, C., Bourdoncle, Pierre, Meissner, Markus   +19 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Non-vesicular glycerolipids transport in plant cells

, 2022
International audienceIn Eukaryotic cells, organelles are delineated by one or several membranes that are composed of a specific assembly of lipids and proteins ensuring the identity of each cell compartment and regulating their biogenesis and function ...
Michaud, Morgane, Morgane Michaud, Leterme, Sébastien, Sébastien Leterme   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

FGF2 Affects Parkinson’s Disease-Associated Molecular Networks Through Exosomal Rab8b/Rab31

Frontiers in Genetics, 2020
Ras-associated binding (Rab) proteins are small GTPases that regulate the trafficking of membrane components during endocytosis and exocytosis including the release of extracellular vesicles (EVs).
Rohit Kumar, Rohit Kumar, Rohit Kumar, Sainitin Donakonda, Stephan A. Müller, Kai Bötzel, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Thomas Koeglsperger, Thomas Koeglsperger   +10 more
doaj   +1 more source

Dual Color, Live Imaging of Vesicular Transport in Axons of Cultured Sensory Neurons

Bio-Protocol, 2021
The function of neurons in afferent reception, integration, and generation of electrical activity relies on their strikingly polarized organization, characterized by distinct membrane domains.
Yoko Bekku, James Salzer
doaj   +1 more source