Results 71 to 80 of about 138,493 (297)

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [PDF]

, 2018
Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood.
Bendor, Jacob, Edwards, Robert H, Levy, Jonathan, Nicoll, Roger A, Pham, Ellen, Seifikar, Helia, Silm, Katlin, Sohal, Vikaas S, Sullivan, Michael, Ullman, Julie C, Yang, Jing   +10 more
core   +3 more sources

The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae [PDF]

Proceedings of the National Academy of Sciences, 2000
To investigate the factors involved in the sorting of cargo proteins into COPII endoplasmic reticulum (ER) to Golgi apparatus transport vesicles, we have created a strain of S. cerevisiae (p24Δ8) that lacks all eight members of the p24 family of transmembrane proteins (Emp24p, Erv25p, and Erp1p to Erp6p).
S, Springer, E, Chen, R, Duden, M, Marzioch, A, Rowley, S, Hamamoto, S, Merchant, R, Schekman   +7 more
openaire   +2 more sources

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. [PDF]

, 2017
Capitalizing on CRISPR/Cas9 gene-editing techniques and super-resolution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.
Baddeley, David, Bewersdorf, Joerg, Bottanelli, Francesca, Erdmann, Roman S, Ernst, Andreas M, Kilian, Nicole, Kromann, Emil B, Lessard, Mark D, Rivera-Molina, Felix, Rothman, James E, Schepartz, Alanna, Schroeder, Lena K, Toomre, Derek   +12 more
core   +2 more sources

Deciphering Small Molecule Diffusion Parameters Across Light Responsive Polymersome Membranes

Advanced Functional Materials, EarlyView.
Light‐responsive polymersomes bearing donor–acceptor Stenhouse adducts (DASAs) enable programmable control over small‐molecule transport across synthetic membranes. By systematically varying DASA density, an optimal functionalization regime is identified that maximizes light‐gated permeability.
Farzina Matubbar, Beyzanur Kaya, Buse Ipek, Tenzin Dorjee, Shoghik Hakobyan, Mohamed Chami, Julien E. Gautrot, Omar Rifaie‐Graham   +7 more
wiley   +1 more source

Regulation of Plasma Membrane Sterol Homeostasis by Nonvesicular Lipid Transport

Contact, 2021
Sterol contributes to the structural integrity of cellular membranes and plays an important role in the regulation of cell signaling in eukaryotes. It is either produced in the endoplasmic reticulum or taken up from the extracellular environment. In most
Dylan Hong Zheng Koh, Yasunori Saheki
doaj   +1 more source

Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport

Biological Chemistry, 2016
Abstract Our understanding of the manner in which Rab proteins regulate intracellular vesicular transport has progressed remarkably in the last one or two decades by application of a wide spectrum of biochemical, biophysical and cell biological methods, augmented by the methods of chemical biology.
Goody, R., Müller, M., Wu, Y.
openaire   +3 more sources

Legionella pneumophila Subversion of Host Vesicular Transport by SidC Effector Proteins [PDF]

Traffic, 2014
Tethering proteins play a key role in vesicular transport, ensuring that cargo arrives at a specific destination. The bacterial effector protein SidC and its paralog SdcA have been described as tethering factors encoded by the intracellular pathogen Legionella pneumophila. Here, we demonstrate that SidC proteins are important for early events unique to
Horenkamp, Florian A, Mukherjee, Shaeri, Alix, Eric, Schauder, Curtis M, Hubber, Andree M, Roy, Craig R, Reinisch, Karin M   +6 more
openaire   +4 more sources

Structure Formation in Butterfly Scales: Interplay of Genetic Control, Mechanical Instabilities, and Dynamic Material Properties

Advanced Functional Materials, EarlyView.
Butterfly wing scales are intricate cuticular functional nanosctructures. This perspective suggests that spatially varying material properties, cytoskeletal constraints, and growth‐driven mechanical instabilities shape the resulting nanoscale architectures created from single cells.
Anupama Prakash, Victoria Lloyd, Yi Yang, Anna‐Lee Jessop, Anthony McDougal, Primož Pirih, Guillaume Duclos, Andrew Parnell, Mathias Kolle, Nicola J. Nadeau, Bodo D. Wilts   +10 more
wiley   +1 more source

The Autopalmitoylated Vesicular Transport Protein Bet3

, 2018
In eukaryotic cells the transport along secretory and endocytic pathways is performed by vesicular carriers. The initial attachment of a vesicle to the target membrane is called tethering. In case of ER-to-Golgi transport this step is performed by the TRAPP (transport protein particle) complex. The subunit Bet3 is present twice in the complex.
openaire   +2 more sources