Results 1 to 10 of about 9,455 (159)

Serotonin signaling modulates growth and motility in juvenile Fasciola hepatica. [PDF]

PLoS Neglected Tropical Diseases
Fasciola hepatica causes fasciolosis, a parasitic disease that poses significant animal and human health challenges. Control relies on flukicides, most of which are adulticides, with only triclabendazole effective against the pathogenic migratory ...
Emily Robb, Sarah Muise, Lana Watt, Rebecca Armstrong, Duncan Wells, Paul McCusker, John Harrington, Andreas Krasky, Paul M Selzer, Nikki J Marks, Aaron G Maule   +10 more
doaj   +2 more sources

Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice. [PDF]

Eur J Pharmacol
Perturbation of dopamine transmission has been implicated as a contributing factor in HIV-1 associated neurocognitive disorders with concurrent methamphetamine (METH) abuse. We have demonstrated that the HIV-1 protein, transactivator of transcription (Tat), decreases dopamine transport through inhibition of vesicular monoamine transporter2 (VMAT2 ...
Zhu J, Cirincione AB, Strauss MJ, Davis SE, Eans SO, Tribbitt DK, Alshakhshir N, McLaughlin JP.   +7 more
europepmc   +3 more sources

HIV‐1 protein Tat inhibits vesicular monoamine transporter‐2 activity in rat striatum [PDF]

Synapse, 2012
HIV-1 neurodegeneration is often associated with symptoms of motor dysfunction (Navia et al., 1986). The basal ganglia, which are critical for the execution of voluntary motor tasks, may be a prominent target of HIV-1 in the brain (Nath et al., 2000). The HIV-1 transactivator of transcription protein (Tat) has been shown to play an active role in HIV-1-
Shaji, Theodore, Wayne A, Cass, Linda P, Dwoskin, William F, Maragos   +3 more
openaire   +2 more sources

SDS-resistant aggregation of membrane proteins: application to the purification of the vesicular monoamine transporter [PDF]

Biochemical Journal, 1996
The vesicular monoamine transporter, which catalyses a H+/monoamine antiport in monoaminergic vesicle membrane, is a very hydrophobic intrinsic membrane protein. After solubilization, this protein was found to have a high tendency to aggregate, as shown by SDS/PAGE, especially when samples were boiled in the classical Laemmli buffer before ...
C, Sagné, M F, Isambert, J P, Henry, B, Gasnier   +3 more
openaire   +2 more sources

Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma [PDF]

Endocrine Pathology, 2019
Neuroblastoma (NB), the most common extracranial cancer in childhood, exhibits neuroendocrine (NE) differentiation. Two well-established NE markers, chromogranin A (CgA) and synaptophysin (syn), are used in the histopathological diagnostics. Our aims were to explore if the NE markers synaptic vesicle protein 2 (SV2) and vesicular monoamine transporter ...
Kleopatra Georgantzi, Apostolos V. Tsolakis, Åke Jakobson, Rolf Christofferson, Eva Tiensuu Janson, Lars Grimelius   +5 more
openaire   +3 more sources

Distribution of Vesicular Monoamine Transporter 2 Protein in Human Brain: Implications for Brain Imaging Studies [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2011
The choice of reference region in positron emission tomography (PET) human brain imaging of the vesicular monoamine transporter 2 (VMAT2), a marker of striatal dopamine innervation, has been arbitrary, with cerebellar, whole cerebral, frontal, or occipital cortices used.
Junchao, Tong, Isabelle, Boileau, Yoshiaki, Furukawa, Li-Jan, Chang, Alan A, Wilson, Sylvain, Houle, Stephen J, Kish   +6 more
openaire   +2 more sources

The First Luminal Domain of Vesicular Monoamine Transporters Mediates G-protein-dependent Regulation of Transmitter Uptake [PDF]

Journal of Biological Chemistry, 2006
The activity of vesicular monoamine transporters (VMATs) is down-regulated by the G-protein alpha-subunits of G(o2) and G(q), but the signaling pathways are not known. We show here that no such regulation is observed when VMAT1 or VMAT2 are expressed in Chinese hamster ovary (CHO) cells.
Brunk, I., Blex, C., Rachakonda, S., Höltje, M., Winter, S., Pahner, I., Walther, D., Ahnert-Hilger, G.   +7 more
openaire   +3 more sources

HIV-1 Tat Protein Decreases Dopamine Transporter Cell Surface Expression and Vesicular Monoamine Transporter-2 Function in Rat Striatal Synaptosomes [PDF]

Journal of Neuroimmune Pharmacology, 2012
The dopamine (DA) transporter (DAT) and vesicular monoamine transporter (VMAT2) proteins interact as a biochemical complex to regulate dopaminergic neurotransmission. We have reported that HIV-1Tat(1-86) decreases the specific [(3)H]DA uptake and [(3)H]WIN 35,428 binding sites without a change in total DAT immunoreactivity in rat striatum (Zhu et al ...
Narasimha M, Midde, Adrian M, Gomez, Jun, Zhu   +2 more
openaire   +2 more sources

Subcellular localization of the antidepressant-sensitive norepinephrine transporter

BMC Neuroscience, 2009
Background Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis.
Winder Danny G, Moore Jessica L, Wright Jane, Shields Angela, Han Qiao, Matthies Heinrich JG, Galli Aurelio, Blakely Randy D   +7 more
doaj   +1 more source

Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: Implications for MDMA neurotoxicity [PDF]

Neurotoxicology and Teratology, 2010
J. Neurochem.(2009)112, 951–962.Abstract3,4‐Methylenedioxymethamphetamine (MDMA; ‘Ecstasy’) is a popular recreational drug used worldwide. This study aimed to determine the effects of this compound on the expression of nerve terminal serotonergic markers in rats.
Dominik K, Biezonski, Jerrold S, Meyer
openaire   +2 more sources