Results 41 to 50 of about 9,455 (159)

Innovative Nanomaterial‐Based Approaches for the Recognition of Amphetamine in Attention Deficit Hyperactivity Disorder Management

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT The rising incidence of amphetamine misuse, particularly in the context of attention deficit hyperactivity disorder treatment, underscores the urgent need for sensitive and effective detection methods. This review examines innovative nanomaterial‐based approaches for AMP detection, emphasizing their advantages over conventional analytical ...
Ilghar Zeinaly, Ghazal Koohkansaadi, Majid Hassanzadeh‐Khanmiri, Ahmad Mobed, Saeid Charsouei, Arash Mohagheghi   +5 more
wiley   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, Volume 183, Issue 9, Page 2123-2138, May 2026.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Superoxide Dismutase (SOD)-mimetic M40403 is protective in cell and fly models of paraquat toxicity: Implications for Parkinson disease [PDF]

, 2016
Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting 3c1-2% of people over 65 years of age. Oxidative damage is considered to play a central role in the progression of Parkinson disease and strong evidence links chronic
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Casella, Luigi, Ferrari, Emanuele, Filograna, Roberta, Godena, Vinay K., Sanchez Martinez, Alvaro, Whitworth, Alexander J.   +8 more
core   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya, Kirsteen N. Browning   +1 more
wiley   +1 more source

Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. [PDF]

, 2012
Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder. Patients have episodes that last 1 to 4 hours and are precipitated by alcohol, coffee, and stress.
Edwards, Robert H, Fan, Xueliang, Fu, Ying-Hui, Hess, Ellen J, Karouani, Maha, Lee, Hsien-yang, Nakayama, Junko, Pothos, Emmanuel N, Ptácek, Louis J, Shen, Yiguo, Xu, Ying   +10 more
core   +2 more sources

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+ exchanger [PDF]

, 2017
This work was funded in part by a Royal Society Wolfson Research Merit Award (to J.P.D). It was also supported by the Wellcome Trust (grant number WT079272AIA) which funded the MALDI TOF-TOF analyser at the BSRC Mass Spectrometry and Proteomics Facility,
Botting, Catherine H., Chahrour, Osama, Dalton, John, Duckett, Katie, Labarbuta, Paola, Law, Christopher, Malone, John   +6 more
core   +1 more source

International Registry of NKX2‐1‐Related Disorders: Clinical, Genetic, and Imaging Perspectives

Movement Disorders, Volume 41, Issue 4, Page 889-900, April 2026.
Abstract Background NKX2‐1–related disorders result from heterozygous variants in NKX2‐1, a gene crucial for brain, lung, and thyroid development. Although movement disorders, hypothyroidism, and neonatal respiratory distress are recognized, the full phenotype and genotype–phenotype relationships remain incompletely defined.
Laia Nou‐Fontanet, Claudia Ravelli, Lydie Burglen, Sol Balsells Mejia, Angel Valls‐Villalba, Elies Roman Schiffels, Alice Innocenti, Beatriz Villafuerte, Ainara Salazar‐Villacorta, Vicente Quiroz, Andrea Sariego Jamardo, Giulia Bonato, Asun Díaz‐Gomez, Alexandra Afenjar, Catheline Vilain, Patricia Dumke da Silva Möller, Deyanira Garcia‐Navas Nuñez, Magdalena Krygier, Maria Judit Molnar, Łukasz Milanowski, Katrin Õunap, Micaela Pauni, Patricia Vega, Raphael Borie, Milena Villamil‐Osorio, Sanem Yilmaz, Dénes Zádori, Marta Zawadzka, Tahsin Stefan Barakat, Sebastian Neuens, Daniel de Natera‐de Benito, Dídac Casas‐Alba, Luca Soliani, Claudio M. de Gusmao, Giacomo Garone, Nicola Specchio, Miryam Carecchio, José C. Moreno, Francesca Magrinelli, Kailash P. Bhatia, Darius Ebrahimi‐Fakhari, Claudia Castiglioni, Manju Ann Kurian, João Nuno Carvalho, Roser Pons, Emmanuel Roze, Diane Doummar, Juan Darío Ortigoza‐Escobar   +47 more
wiley   +1 more source

Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission.: Accumbic DA system in STOP KO mice [PDF]

, 2008
International audienceThe microtubule-associated stable tubule only polypeptide (STOP) protein plays a key-role in neuron architecture and synaptic plasticity.
Bouvrais-Veret C., Brenner E., Eastwood S. L., Giros B., Gurevich E. V., Lowry O. H., Owen M. J., Shimizu H., Stanwood G. D., Weiss S., Winklbaur B., Zervas M.   +11 more
core   +3 more sources

Chemically Selective Nanoelectrode Arrays for Real‐Time, Parallel Neurotransmitter and Electrical Recording

Small Science, Volume 6, Issue 4, April 2026.
In this work, the authors demonstrate proof‐of‐concept, multimodal recordings of dopamine and intracellular electrical activity from differentiated SH‐SY5Y neuronal networks using graphite‐modified nanopillar electrode arrays. This study paves the way for multimodal, single cell experiments on neuronal networks to elucidate the dynamics between ...
Shivani Shukla, An‐Yi Chang, Anum Tahir, Muhammad Inam Khan, Maria Reynoso, Ashley Pham, Yuma Dugas, Ian McGregor, Nawab John Dar, Noel Sebastien D Mallari, Dhivya Pushpa Meganathan, Adam T. Woolley, Joseph Wang, Zeinab Jahed   +13 more
wiley   +1 more source