Results 61 to 70 of about 9,455 (159)

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae, Jessica Marie Hunter Alberhasky, Marion Baillet, Debra A. Bangasser, Michael E. Belloy, Anne S. Berry, Chiara Berteotti, Hannah Bow, Rachel Buckley, Jessica Z. K. Caldwell, Matteo Carpi, Benjamin J. Clark, Claire J. Ciampa, Alexander C. Conley, Martin J. Dahl, Zoe R. Donaldson, Alexander J. Ehrenberg, Gillian Einstein, Neus Falgàs, Haley A. Fenlon, Megan C. Fitzhugh, Robert C. Froemke, Clara Gallay, Lea Tenenholz Grinberg, Derek A. Hamilton, Zia Hasan, Oihane Uriarte Huarte, Shaista Jabeen, Heidi I. L. Jacobs, Louis John Kolling, Elouise A. Koops, Sabrina Lenzoni, Claudio Liguori, Riccardo Manca, Catherine A. Marcinkiewcz, Tamunotonye Omoluabi, Rademene Oria, Caitlin A. Orsini, Nancy Elizabeth Ortega, Judy Pa, Nathan S. Pentkowski, Joana B. Pereira, Rhudovic Ramos, Derya Sargin, Abhijit Satpati, Maria Clara Selles, Mabel Seto, Shabana M. Shaik, Shireen Sindi, Gowoon Son, Valentine Ucheagwu, Maxime Van Egroo, Qi Yuan, Michael A. Kelberman   +53 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Transporters [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +150 more
core   +4 more sources

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Tyrosine hydroxylase deficiency (THD) is a rare genetic disorder caused by biallelic pathogenic variants in the Th gene, leading to a deficiency in the rate‐limiting enzyme for the synthesis of dopamine (DA) and other catecholamine neurotransmitters.
Tie‐Jun Sten Shi, Kunwar Jung‐KC, Gong‐Wei Lyu, Liang Han, Ming Ying, Beat Thöny, Aurora Martinez   +6 more
wiley   +1 more source

The golgin coiled-coil proteins capture different types of transport carriers via distinct N-terminal motifs [PDF]

, 2017
Background The internal organization of cells depends on mechanisms to ensure that transport carriers, such as vesicles, fuse only with the correct destination organelle.
Wong, Mie, Gillingham, Alison K, Munro, Sean   +2 more
core   +1 more source

Acetylcholine release and the cholinergic genomic locus [PDF]

, 2018
Choline acetyltransferase and vesicular acetylcholine-transporter genes are adjacent and coregulated. They define a cholinergic locus that can be turned on under the control of several factors, including the neurotrophins and the cytokines. Hirschprung's
Dunant, Yves, Israël, Maurice
core  

Post translational changes to α-synuclein control iron and dopamine trafficking : a concept for neuron vulnerability in Parkinson's disease [PDF]

, 2017
Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a
A Binolfi, A Binolfi, A Binolfi, A Iyer, A Lundby, AA Belaidi, AL Bartels, AM Snyder, AS Maltsev, AS Maltsev, AW Oaks, B Alvarez-Castelao, B Butler, B Fauvet, B Greten-Harrison, B Todorich, B Van Do, B Winner, B Wu, Bruce X. Wong, BX Wong, BX Wong, C Follmer, CB Glaser, CC Winterbourn, CL Kragh, CL Pham, David Devos, David P. Smith, DG Graham, DJ Hare, DJ Surmeier, DS Goldstein, DT Dexter, DT Dexter, E Dragicevic, E Sofic, EA Waxman, EH Norris, EV Mosharov, F Schmidt, FX Theillet, G Lee, G Yamin, G Yin, GS Nubling, H Fujiwara, H Jiang, Hannah Durham, HS Maker, I Dikiy, I Dikiy, ISS Bharathi, J Burre, J Kosten, J Salazar, J Segura-Aguilar, J Sian-Hulsmann, J Wang, JA Duce, James A. Duce, Jean-Christophe Devedjian, JM Graham, JP Anderson, JT Rogers, K Neupane, K Schulz, K Taguchi, KA Conway, KA Conway, KA Jellinger, KE Paleologou, KE Paleologou, KJ Vargas, KR Chaudhuri, KY Chau, L Chen, L Chen, L Hopes, L Yavich, LH Sanders, LR Lemkau, M Bisaglia, M Fiske, M Lundblad, M Sharma, M Takahashi, M Ulla, MB Fares, MG Spillantini, MH Polymeropoulos, MJ Diogenes, MJ Hokenson, MK Mbefo, N Golts, N Jahanshad, N Ostrerova, N Ostrerova-Golts, N Pandey, N Plotegher, N Song, NJ Rutherford, NP Visanji, O Wise-Scira, OM El-Agnaf, OS Gorbatyuk, P Lei, P Munoz, QX Li, R Cappai, R Kruger, R Porcari, RA Fredenburg, RC Carter, RG Perez, RT MacGillivray, S Arawaka, S Ayton, S Ayton, S Ayton, S Azeredo da Silveira, S Baksi, S Bhatnagar, S Chandra, S Hara, S Lesage, S Olivieri, S Schreurs, SA Schneider, SL Leong, SY Jeong, T Bartels, TF Outeiro, U Dettmer, V Sancenon, VM Nemani, VN Uversky, VN Uversky, VN Uversky, VS Kokhan, W Choi, WS Woods, WW Smith, Y Lu, Y Peng, ZI Cabantchik   +145 more
core   +2 more sources

Vesicular Amine Transporter VMAT2 in the Rat Ileum: from Principal Mechanism to Clinical Applications [PDF]

, 2015
Besides the role of a classical neurotransmitter, histamine plays a key role in the immune/inflammatory processes in the gastrointestinal tract. Specific transport proteins pack the amine neurotransmitters into vesicles so that their release can be ...
Stoyanova, I.I.
core   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. [PDF]

, 2011
Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD).
Akil, H, Barchas, JD, Bernard, R, Bunney, WE, Jones, EG, Kerman, IA, Myers, RM, Schatzberg, AF, Thompson, RC, Watson, SJ   +9 more
core  

Dopamine and Acetylcholine, a Circuit Point of View in Parkinson’s Disease [PDF]

, 2017
Data from the World Health Organization (National Institute on Aging, 2011) and the National Institutes of Health (He et al., 2016) predicts that while today the worldwide population over 65 years of age is estimated around 8.5%, this number will reach ...
Rizzi, Giorgio, Tan , Kelly R.
core   +2 more sources