Results 51 to 60 of about 9,455 (159)

Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats [PDF]

, 2016
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During 29 menopause, this complex signaling declines, leading to impaired learning and memory.
Hrabovszky, Erik, Kalló, Imre, Liposits, Zsolt, Solymosi, Norbert, Sárvári, Miklós   +4 more
core   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Identification of a mammalian vesicular polyamine transporter [PDF]

, 2014
Spermine and spermidine act as neuromodulators upon binding to the extracellular site(s) of various ionotropic receptors, such as N-methyl-d-aspartate receptors. To gain access to the receptors, polyamines synthesized in neurons and astrocytes are stored
Harada, Yuika, Haruna, Yuka, Hiasa, Miki, Miyaji, Takaaki, Moriyama, Sawako, Moriyama, Yoshinori, Omote, Hiroshi, Takeuchi, Tomoya, Yamamoto, Akitsugu   +8 more
core   +1 more source

When Pathways Converge: Iron, Lipid Peroxidation, and α‐Synuclein in Ferroptosis‐Driven Dopaminergic Neurodegeneration

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Dopaminergic neurons are particularly susceptible to ferroptosis. Pacemaking activity–driven calcium (Ca2+) influx increases metabolic demand and reactive oxygen species (ROS) production, promoting iron release from aconitase. Alpha‐synuclein (α‐syn) enhances iron uptake via transferrin receptor 1 (TfR1) and exhibits ferrireductase activity, converting
Carmem L. Sperlich, Brent R. Stockwell, Marcelo Farina   +2 more
wiley   +1 more source

DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis [PDF]

, 2017
DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson’s disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD.
Alvarez-Erviti, Lydia, Bansal, Vikas, Bjorkblom, Benny, Bonn, Stefan, Breuer, Peter, Gargano, Daniela, Gegg, Matthew E., Geir Moller, Simon, Kaut, Oliver, Larsen, Jan Petter, Maple-Grødem, Jodie, Odell, Mark, Piston, Dominic, Puno, M. Rhyan, Schapira, Anthony H. V., Szabadkai, Gyorgy, Wullner, Ullrich, Yao, Zhi   +17 more
core   +3 more sources

Phenotypic Clues in Infantile‐Onset Parkinsonism‐Dystonia‐2: A Treatable Neurotransmitter Disorder

Movement Disorders Clinical Practice, EarlyView.
Sangeetha Yoganathan, Haya S. AlFaris, Lindsey Vogt, Michele Eid, Anika Menetrey, Sayoni Roy Chowdhury, Dawn Codeiro, Pradeep Krishnan, Liali Aljouda, Emily W.Y. Tam, Carolina Gorodetsky   +10 more
wiley   +1 more source

Methylglyoxal Affects Dopamine Homeostasis in SH‐SY5Y Cells Through the Modulation of miR‐190a and miR‐214

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Alessandra Croce, Paola Mirra, Francesca Chiara Pignalosa, Federica Zatterale, Immacolata Prevenzano, Domenico Conza, Luca Ulianich, Claudia Miele, Francesco Beguinot, Francesca Fiory   +9 more
wiley   +1 more source

Interactions of Cathinone NPS with Human Transporters and Receptors in Transfected Cells [PDF]

, 2017
Pharmacological assays carried out in transfected cells have been very useful for describing the mechanism of action of cathinone new psychoactive substances (NPS).
A Chamba, A Derungs, A Rickli, A Rickli, A Rickli, AJ Eshleman, AJ Eshleman, AJ Eshleman, AV Kalueff, B Bang-Andersen, B Cara Di, B Hilber, B O’Neill, BG Wilhelm, BJ Thompson, BL Murray, BT Burlingham, C Achat-Mendes, C Hysek, C Pifl, CD Verrico, CG Tate, CM Hysek, CM Hysek, CM Hysek, CM Hysek, CM Hysek, CT Bauer, D Groskreutz, D Marazziti, D Sulzer, D Viggiano, DE Nichols, DM Mueller, EA Ross, EL Barker, F Xu, FA Ran, FG Revel, G Rudnick, H Khoshbouei, HA Borek, HC Prasad, I Sora, J Talvenheimo, JJ Maguire, JO Marcusson, L Iversen, L Jing, L Simmler, LD Simmler, LD Simmler, LD Simmler, LK Henry, LL Howell, LR Watterson, LR Watterson, M Liechti, M Raiteri, M Tatsumi, M Torok, MA Mergy, ME Liechti, MH Baumann, MH Baumann, MS Mazei-Robison, MT Brown, OT Ukairo, P Scholze, PJ Nelson, R Rosenauer, R Torre de la, R Zhang, RA Johnson, RA Prosser, RB Rothman, RB Rothman, RB Rothman, RB Rothman, S Chaudhary, S Ramamoorthy, S Wee, SB Caine, SL Hill, T Steinkellner, Y Cheng, Y Schmid, Y Schmid   +87 more
core   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, Volume 13, Issue 14, 9 March 2026.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder [PDF]

, 2016
Several reports suggest obesity and bipolar disorder (BD) share some physiological and behavioural similarities. For instance, obese individuals are more impulsive and have heightened reward responsiveness, phenotypes associated with BD, while bipolar ...
Akram, M, Ambrosi, V, Dnyansagar, R, Eriksson, A, Fredriksson, R, Hallqvist, E, Kasagiannis, A, Kheder, S, Klockars, A, Schiöth, HB, Voisin, Sarah, Wiemerslage, L, Williams, MJ   +12 more
core   +3 more sources