Results 21 to 30 of about 9,455 (159)

Presynaptic Molecular Determinants of Quantal Size [PDF]

, 2016
The quantal hypothesis for the release of neurotransmitters at the chemical synapse has gained wide acceptance since it was first worked out at the motor endplate in frog skeletal muscle in the 1950s.
Shigeo Takamori
core   +2 more sources

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]

, 2009
Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Baur, Dorothee M., Besig, Sophie, Braun, Thomas, Hoefler, Heinz, Langer, Rupert, Perren, Aurel, Prinz, Christian, Rad, Roland, Voland, Petra   +8 more
core   +2 more sources

Chromogranin A and Vesicular Monoamine Transporter 2 Immunolocalization in Protein Bodies of Human Locus Coeruleus Neurons

Ultrastructural Pathology, 2013
Our previous histochemical and ultrastructural studies have identified, in human catecholamine neurons, abundant spherical acidophilic protein bodies (pb), which originate from regular mitochondria, retaining their double membrane. In locus coeruleus (LC) neurons, pb have somatodendritic distribution and are unequivocal storage vesicles for ...
Kloukina-Pantazidou, I., Chrysanthou-Piterou, M., Havaki, S., Issidorides, M.R.   +3 more
openaire   +3 more sources

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

AGC1-malate aspartate shuttle activity is critical for dopaminehandling in the nigrostriatal pathway [PDF]

, 2013
This is the pre-peer reviewed version of the following article: Llorente-Folch, I. et al. "AGC1-malate aspartate shuttle activity is critical for dopaminehandling in the nigrostriatal pathway".
Casarejos, María José, Contreras, Laura, Dierssen, Mara, Grau, Josep María, Llorente-Folch, Irene, Mena, María Angeles, Pardo, Beatriz, Saheki, Takeyori, Sahún, Ignasi, Satrústegui, Jorgina   +9 more
core   +2 more sources

Monoaminergic modulation of photoreception in ascidian:evidence for a proto-hypothalamo-retinal territory [PDF]

, 2012
Background : The retina of craniates/vertebrates has been proposed to derive from a photoreceptor prosencephalic territory in ancestral chordates, but the evolutionary origin of the different cell types making the retina is disputed.
Brown, Euan R, Callebert, Jacques, Horie, Takeo, Joly, Jean-Stéphane, Kusakabe, Takehiro G, Razy-Krajka, Florian, Sasakura, Yasunori, Vernier, Philippe   +7 more
core   +5 more sources

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. [PDF]

, 2009
Uptake through the dopamine transporter (DAT) represents the primary mechanism used to terminate dopaminergic transmission in brain. Although it is well known that dopamine (DA) taken up by the transporter is used to replenish synaptic vesicle stores for
Baust, Tracy B, Cuevas, Rolando A, Dorostkar, Mario M, Egaña, Loreto A, Hochendoner, Sarah, Hong, Weimin C, Janz, Roger, Leak, Rehana K, Parra, Leonardo A, Peña, Karina, Quiroz, Marisol, Sitte, Harald H, Torres, Gonzalo E   +12 more
core   +1 more source

Is Parkinson's disease a vesicular dopamine storage disorder?: Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum [PDF]

, 2014
The cause of degeneration of nigrostriatal dopamine (DA) neurons in idiopathic Parkinson’s disease (PD) is still unknown. Intraneuronally, DA is largely confined to synaptic vesicles where it is protected from metabolic breakdown.
Blesa, Javier, Cavada, Carmen, Hornykiewicz, Oleh, Obeso, José A., Pifl, Christian, Rajput, Alex, Rajput, Ali H., Reither, Harald   +7 more
core   +3 more sources

Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]

, 1971
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W., Ashwell M., Beattie D. S., Beattie D. S., Brunner G., Burstone M. S., Davis K. A., Delbruck A., Fiske C. H., Folch J., Gear A. R. L., Gear A. R. L., Gear A. R. L., Gelder B. F., Gotterer G. S., Hasegawa E., Hawley E. S., Johnson A. B., Klingenberg M., Kuntzel H., Labbe R. F., Lentz P. E., Neupert W., Neupert W., Novikoff A. B., Ohnishi K., Omura T., Parsons D. F., Parsons D. F., Pette D., Pollak J. K., Pullmann M. E., Raw J., Raw J., Reith A., Schneider W. C., Schuel H., Schumacher H.-H., Sebald W., Sebald W., Seligman A. M., Sies H., Sottocasa G. L., Stoffel W., Strecker H. J., Swick R. W., Szarkowska L., Tabor C. W., Tol A., Vazquez J. J., Yonetani T.   +50 more
core   +1 more source

Engineering of a mammalian VMAT2 for cryo-EM analysis results in non-canonical protein folding

Nature Communications
Vesicular monoamine transporter 2 (VMAT2) belongs to the major facilitator superfamily (MFS), and mediates cytoplasmic monoamine packaging into presynaptic vesicles. Here, we present two cryo-EM structures of VMAT2, with a frog VMAT2 adopting a canonical
Ying Lyu, Chunting Fu, Haiyun Ma, Zhaoming Su, Ziyi Sun, Xiaoming Zhou   +5 more
doaj   +1 more source