Golgi Apparatus Regulates Plasma Membrane Composition and Function
Cells, 2022 Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp ...
Ilenia Agliarulo +1 more
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Signal peptide peptidase‐like 2c impairs vesicular transport and cleaves SNARE proteins [PDF]
EMBO reports, 2019 Members of the GxGD-type intramembrane aspartyl proteases have emerged as key players not only in fundamental cellular processes such as B-cell development or protein glycosylation, but also in development of pathologies, such as Alzheimer's disease or hepatitis virus infections.
Alkmini A Papadopoulou +11 more
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Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. [PDF]
, 2018 L-type CaV1.2 channels are key regulators of gene expression, cell excitability and muscle contraction. CaV1.2 channels organize in clusters throughout the plasma membrane.
Brust-Mascher, Ingrid +8 more
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Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells
Cell & Bioscience, 2020 Background Eukaryotic cells demonstrate two tightly linked vesicular transport systems, comprising intracellular vesicle transport and extracellular vesicle transport system.
Leila Salimi +9 more
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Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]
, 1981 Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
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Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. [PDF]
Proceedings of the National Academy of Sciences, 1988 N-Ethylmaleimide (NEM) inhibits protein transport between successive compartments of the Golgi stack in a cell-free system. After inactivation of the Golgi membranes by NEM, transport can be rescued by adding back an appropriately prepared cytosol fraction. This complementation assay has allowed us to purify the NEM-sensitive factor, which we term NSF.
M R, Block +4 more
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Non-vesicular Lipid Transport Machinery in Entamoeba histolytica
Frontiers in Cellular and Infection Microbiology, 2018 Eukaryotic cells are organized into separate membrane-bound compartments that have specialized biochemical signature and function. Maintenance and regulation of distinct identity of each compartment is governed by the uneven distribution and intra ...
Koushik Das, Tomoyoshi Nozaki
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Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells [PDF]
, 2017 Wolbachia are intracellular maternally inherited bacteria that can spread through insect populations and block virus transmission by mosquitoes, providing an important approach to dengue control.
Ant, Thomas H. +9 more
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Ganglioside GM2-Activator Protein and Vesicular Transport in Collecting Duct Intercalated Cells [PDF]
Journal of the American Society of Nephrology, 1999 Abstract. This study describes the molecular characterization of an antigen defined by an autoantibody from a woman with habitual abortion as GM2-activator protein. The patient showed no disorder of renal function. Accidentally with routine serum screening for autoantibodies, an immunoreactivity was found in kidney collecting ...
T M, Mundel +4 more
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Vesicular Transport and Amyloids: The Growing Relationship
BiologicsProtein aggregation may lead to detrimental changes in brain and several other tissues. Amyloids or large protein aggregates are formed in different brain areas under multiple diseases classified as proteinopathies.
Arun Upadhyay
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