Results 231 to 240 of about 57,494 (245)

Anti lag3 vhhs and their use

2022
The present disclosure relates to field of immune checkpoints in onco-immunology and their identification as potential targets for the treatment of cancer patients : it provides VHHs (Single-domain antibody fragments, also known as 'heavy-chain variable domains' or 'nanobodies') to detect and quantify in a non-invasive way the immune checkpoint LAG-3.
Breckpot, Karine, Broos, Katrijn, Devoogdt, Nick, Lecocq, Quentin, Keyaerts, Marleen, Raes, Geert   +5 more
openaire   +4 more sources

Structure and Function of Camelid VHH

2016
The humoral immune response of camels and llama’s is unique in containing two types of IgG antibodies: classical heterotetrameric and homodimeric heavy chain-only antibodies (HCAbs). Remarkably, these heavy chain antibodies are functional in antigen binding and reach high titers and affinities after immunizing a camelid. Antigen recognition by HCAbs is
Vincke, Cecile, Muyldermans, Serge
openaire   +2 more sources

VHH Atmospheric concentration in urban/rural areas and biological monitoring

Toxicological & Environmental Chemistry, 1991
Volatile halogenated hydrocarbon (VHH) represent an important human risk factor consequently to their mutagenic and carcinogenic properties. The present study has considered the following items: i) evaluation of VHH air contamination in an urban and in a rural site, during winter and summer, ii) measurement of VHH in blood of donors living in the same ...
GILLI, Giorgio, BONO, Roberto, BREZZO E, GUERRINI E, SCURSATONE, Vincenzo   +4 more
openaire   +3 more sources

A high affinity and specificity anti-HER2 single-domain antibody (VHH) that targets trastuzumab’s epitope with versatile biochemical, biological, and medical applications

Immunologic research, 2023
S. K. Nikkhoi, Hediyeh Heydarzadeh, V. Vandavasi, Ge Yang, Pedro Louro, M. Polunas, Hajar Owji, A. Hatefi   +7 more
semanticscholar   +1 more source

TUNABLE HYDROGEL-BASED VHH DELIVERY FOR INTRA-ARTICULAR OSTEOARTHRITIS THERAPY

Osteoarthritis and Cartilage
Purpose (the aim of the study): Current osteoarthritis (OA) treatments based on intra-articular injections provide only temporary relief due to fast clearance from the joint. This calls for innovative therapeutic strategies for the long-term sustained release of therapeutics inside the joint space.
Larrea, Carolina Serrano, Morshuis, Lisanne, Le, Thanh, Zhong, Lin, Zoetebier, Bram, Karperien, Marcel   +5 more
openaire   +1 more source

Introduction of PMMA-Tag to VHH for improving recovery and immobilization rate of VHHs

3rd Annual International Conference on Chemistry, Chemical Engineering and Chemical Process (CCECP 2015), 2015
Bongmun Kang, Yoiichi Kumada
openaire   +1 more source

Development of an ^18F-labeled anti-human CD8 VHH for same-day immunoPET imaging

European Journal of Nuclear Medicine and Molecular Imaging, 2022
S. Sriraman, C. Davies, H. Gill, J. Kiefer, Jianping Yin, A. Ogasawara, A. Urrutia, Vincent Javinal, Zhonghua Lin, D. Seshasayee, Ryan Abraham, P. Haas, C. Koth, J. Mařík, J. T. Koerber, Simon-Peter Williams   +15 more
semanticscholar   +1 more source

VHH

2011
openaire   +1 more source

VHH

2006
openaire   +1 more source

Intra-cellular VHH targeting the FSHR and LHR

Intracellular variable fragments from heavy-chain antibody from camelids (intra-VHH) have beensuccessfully used as chaperones to solve the 3D structure of active G protein-coupled receptors(GPCRs) bound to their cognate transducers. They may also provide a better understanding onthe relationships between receptor conformation and signalling activity ...
openaire   +1 more source