Results 91 to 100 of about 509,068 (300)

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism, but not in suckling [PDF]

, 2012
The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been ...
Abramowitz J, Balthasar N, Bamshad M, Bartness TJ, Bastepe M, Bastepe M, Baxendale RW, Bunting M, Castrop H, Cattanach BM, Cattanach BM, Chen M, Chen M, Chen M, Chotalia M, Crawford JA, de Bovis B, de Paula FJ, Ducy P, Elefteriou F, Friedman JM, Fu L, Fukao M, Germain-Lee EL, Hayward BE, Holmes R, Ivanova E, Kawai M, Kaya AI, Kehlenbach RH, Kelly ML, Kelsey G, Klemke M, Klemke M, Kublaoui BM, Lam DD, Liu J, Maffei M, Moore T, Oswal A, Pasolli HA, Pasolli HA, Peters J, Peters J, Peters J, Plagge A, Plagge A, Sakamoto A, Sakamoto A, Schmidt-Nielsen K, Shin JY, Shrestha YB, Skinner JA, Sleutels F, Storck T, Weinstein LS, Weinstein LS, Williamson CM, Williamson CM, Williamson CM, Wroe SF, Xie T, Yadav VK, Youngstrom TG, Yu S, Yu S   +65 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Circumstantial Disconnection: Homelessness and Parental Relationships with Children [PDF]

, 2016
This article looks at homeless individuals to see how they think their residential situation affects their relationship with their non-homeless children. Using a survey of 75 homeless parents in Houston, Texas this analysis finds that homeless parents of
Branham, David, Sr., Holland, Jonathan
core   +1 more source

Advances in imaging chest tuberculosis: blurring of differences between children and adults [PDF]

, 2009
This article reviews the ongoing role of imaging in the diagnosis of tuberculosis (TB) and its complications. A modern imaging classification of TB, taking into account both adults and children and the blurring of differences in the presentation patterns,
Ahmad, Al-Nasser, Andronikou, Andronikou, Andronikou, Andronikou, Andronikou, Bosch-Marcet, Bosch-Marcet, Buckingham, Burrill, Casas, Conces, De Backer, De Backer, De Villiers, den Boon, du Plessis, Erlank, Erlank, Fraser, Glicklich, Goodman, Goussard, Griffith-Richards, Grobbelaar, Gulati, Hamilton, Haramati, Hartman, Hopewell, Im, Jeong, Kim, Kim, Lee, Lee, Leung, Lighter, Marais, Maydell, Moon, Morris, Nakanishi, Neufang, Perlman, Raviglione, Reid, Rodriguez, Santelli, Scheepers, Stead, Swingler, Theron, Van Dyck, Van Rie, Vanhoenacker, Verver, Verver, Wall, Westcott, Woodring, Yilmaz, Zellweger   +63 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Commentary: Needle goniotomy in adults: Is it a viable minimally-invasive glaucoma surgery option?

Indian Journal of Ophthalmology, 2022
Vanita Pathak Ray
doaj   +1 more source

Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up [PDF]

, 2017
The overall number of day-case otologic surgery cases is increasing; however, there is limited experience about performing canal wall down tympanoplasty in patients with chronic suppurative otitis media with cholesteatoma in this setting.
GRASSO, MICHELE, NOLA, GIUSEPPE, RALLI, Giovanni, RALLI, MASSIMO, TAGLIONI, ALBERTO   +4 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The persistence of wishful thinking: Response to "Updated thinking on positivity ratios" [PDF]

, 2014
This is a response to Barbara Fredrickson's comment [American Psychologist 68, 814-822 (2013)] on our article arXiv:1307.7006. We analyze critically the renewed claims made by Fredrickson (2013) concerning positivity ratios and "flourishing", and ...
Brown, Nicholas J. L., Friedman, Harris L., Sokal, Alan D.   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source