The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction [PDF]
A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired.
Benzer, Seymour +4 more
core
Alfalfa Snout Beetle, \u3ci\u3eOtiorhynchus Ligustici\u3c/i\u3e L. (Coleoptera: Curculionidae): Methods for Egg Collection and Larval Rearing [PDF]
The alfalfa snout beetle, Otiorhynchus ligustici L., is the most serious pest of alfalfa in northern New York State. Recent research efforts focused on the biological control of this insect require the availability of all life stages.
Neumann, Gabor +2 more
core +2 more sources
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Report to the New York City Housing Authority on Applying and Lifting Permanent Exclusions for Criminal Conduct [PDF]
The New York City Housing Authority (NYCHA) is conducting an internal review of its policies related to permanent exclusions for criminal conduct on NYCHA property. Permanent exclusion (PE) occurs when a NYCHA tenant—rather than risk eviction—enters into
Gregory Umbach +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Background/Objectives: Early gut colonization by bifidobacteria, occurring more favorably in vaginally born infants than in those delivered via C-section, is crucial for maintaining overall health.
Barbara Giordani +10 more
doaj +1 more source
Realizing Health Reform's Potential: When Unemployed Means Uninsured: The Toll of Job Loss on Health Coverage, and How the Affordable Care Act Will Help [PDF]
Examines how the 2010 healthcare reform will significantly expand affordable health coverage options for the unemployed who cannot afford COBRA. Calls for re-establishing COBRA premium subsidies to bridge coverage gaps until it is implemented in ...
Michelle M. Doty +3 more
core
Preventing extinction and outbreaks in chaotic populations
Interactions in ecological communities are inherently nonlinear and can lead to complex population dynamics including irregular fluctuations induced by chaos.
Hilker, Frank M., Westerhoff, Frank H.
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source

