Results 1 to 10 of about 5,256,511 (351)

Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV Replication

Biomedicines, 2021
Hepatitis B virus (HBV) X protein (HBx) is a viral regulatory and multifunctional protein. It is well-known that the canonical HBx reading frame bears two phylogenetically conserved internal in-frame translational initiation codons at Met2 and Met3, thus
Sergio Hernández, Francisca Álvarez-Astudillo, Daniel Garrido, Cristian Prieto, Alejandra Loyola, Rodrigo A. Villanueva   +5 more
doaj   +1 more source

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Scientific Reports, 2021
Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders.
Cristian Doñas, Jocelyn Neira, Francisco Osorio-Barrios, Macarena Carrasco, Dominique Fernández, Carolina Prado, Alejandra Loyola, Rodrigo Pacheco, Mario Rosemblatt   +8 more
doaj   +1 more source

Pre- and Post-Transcriptional Control of HBV Gene Expression: The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions

Biomedicines, 2023
Hepatitis B virus (HBV) is an enveloped DNA human virus belonging to the Hepadnaviridae family. Perhaps its main distinguishable characteristic is the replication of its genome through a reverse transcription process. The HBV circular genome encodes only
Rodrigo A. Villanueva, Alejandra Loyola
doaj   +1 more source

Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity

Journal of Neuroinflammation, 2021
Background Recent evidence has shown dopamine as a major regulator of inflammation. Accordingly, dopaminergic regulation of immune cells plays an important role in the physiopathology of inflammatory disorders.
Carolina Prado, Francisco Osorio-Barrios, Paulina Falcón, Alexandra Espinoza, Juan José Saez, María Isabel Yuseff, Rodrigo Pacheco   +6 more
doaj   +1 more source

A Large-Scale Genome-Based Survey of Acidophilic Bacteria Suggests That Genome Streamlining Is an Adaption for Life at Low pH

Frontiers in Microbiology, 2022
The genome streamlining theory suggests that reduction of microbial genome size optimizes energy utilization in stressful environments. Although this hypothesis has been explored in several cases of low-nutrient (oligotrophic) and high-temperature ...
Diego Cortez, Gonzalo Neira, Carolina González, Eva Vergara, David S. Holmes, David S. Holmes   +5 more
doaj   +1 more source

Nanosecond pulsed electric field (nsPEF) and vaccines: a novel technique for the inactivation of SARS-CoV-2 and other viruses?

Annals of Medicine, 2022
Since the beginning of 2020, worldwide attention has been focused on SARS-CoV-2, the second strain of the severe acute respiratory syndrome virus.
A. R. Ruiz-Fernández, M. Rosemblatt, T. Perez-Acle   +2 more
doaj   +1 more source

Draft genome sequence of the type strain of the sulfur-oxidizing acidophile, Acidithiobacillus albertensis (DSM 14366)

Standards in Genomic Sciences, 2017
Acidithiobacillus albertensis is an extremely acidophilic, mesophilic, obligatory autotrophic sulfur-oxidizer, with potential importance in the bioleaching of sulfidic metal ores, first described in the 1980s. Here we present the draft genome sequence of
Matías Castro, Ana Moya-Beltrán, Paulo C. Covarrubias, Mónica Gonzalez, Juan Pablo Cardenas, Francisco Issotta, Harold Nuñez, Lillian G. Acuña, Gonzalo Encina, David S. Holmes, D. Barrie Johnson, Raquel Quatrini   +11 more
doaj   +1 more source

Correlação entre uso de álcool e drogas e o risco de suicídio em pessoas diagnosticadas com transtorno afetivo bipolar: uma visão geral

Debates em Psiquiatria, 2023
Introdução: O transtorno afetivo bipolar (TAB) é uma condição psiquiátrica complexa, caracterizada por alterações extremas de humor, incluindo episódios de mania e depressão. A relação entre o uso de álcool, drogas e o risco de suicídio em pacientes com
Stéfanie Venturini Fanton, Marilene Ferraz Cavalieri, Carla Tereza Ruiz Cerqueira, Lucas Pilla Garcia, Marcela Bezerra Zanusso, Carolina Capelasso de Oliveira   +5 more
doaj   +1 more source

Detecting activity cycles of late-type dwarfs in Kepler data [PDF]

, 2013
Using data of fast-rotating active dwarf stars in the Kepler database, we perform time-frequency analysis of the light curves in order to search for signs of activity cycles.
Oláh, K., Vida, K.
core   +1 more source

Commitments, Intentions, Truth and Nash Equilibria [PDF]

, 2013
Games with multiple Nash equilibria are believed to be easier to play if players can communicate. We present a simple model of communication in games and investigate the importance of when communication takes place. Sending a message before play captures
Schlag, Karl H., Vida, Péter
core   +2 more sources