Results 1 to 10 of about 4,725,133 (183)

Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV Replication

open access: yesBiomedicines, 2021
Hepatitis B virus (HBV) X protein (HBx) is a viral regulatory and multifunctional protein. It is well-known that the canonical HBx reading frame bears two phylogenetically conserved internal in-frame translational initiation codons at Met2 and Met3, thus
Sergio Hernández   +5 more
doaj   +1 more source

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

open access: yesScientific Reports, 2021
Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders.
Cristian Doñas   +8 more
doaj   +1 more source

Pre- and Post-Transcriptional Control of HBV Gene Expression: The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions

open access: yesBiomedicines, 2023
Hepatitis B virus (HBV) is an enveloped DNA human virus belonging to the Hepadnaviridae family. Perhaps its main distinguishable characteristic is the replication of its genome through a reverse transcription process. The HBV circular genome encodes only
Rodrigo A. Villanueva, Alejandra Loyola
doaj   +1 more source

Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity

open access: yesJournal of Neuroinflammation, 2021
Background Recent evidence has shown dopamine as a major regulator of inflammation. Accordingly, dopaminergic regulation of immune cells plays an important role in the physiopathology of inflammatory disorders.
Carolina Prado   +6 more
doaj   +1 more source

A Large-Scale Genome-Based Survey of Acidophilic Bacteria Suggests That Genome Streamlining Is an Adaption for Life at Low pH

open access: yesFrontiers in Microbiology, 2022
The genome streamlining theory suggests that reduction of microbial genome size optimizes energy utilization in stressful environments. Although this hypothesis has been explored in several cases of low-nutrient (oligotrophic) and high-temperature ...
Diego Cortez   +5 more
doaj   +1 more source

Nanosecond pulsed electric field (nsPEF) and vaccines: a novel technique for the inactivation of SARS-CoV-2 and other viruses?

open access: yesAnnals of Medicine, 2022
Since the beginning of 2020, worldwide attention has been focused on SARS-CoV-2, the second strain of the severe acute respiratory syndrome virus.
A. R. Ruiz-Fernández   +2 more
doaj   +1 more source

Correlação entre uso de álcool e drogas e o risco de suicídio em pessoas diagnosticadas com transtorno afetivo bipolar: uma visão geral

open access: yesDebates em Psiquiatria, 2023
Introdução: O transtorno afetivo bipolar (TAB) é uma condição psiquiátrica complexa, caracterizada por alterações extremas de humor, incluindo episódios de mania e depressão. A relação entre o uso de álcool, drogas e o risco de suicídio em pacientes com
Stéfanie Venturini Fanton   +5 more
doaj   +1 more source

Draft genome sequence of the type strain of the sulfur-oxidizing acidophile, Acidithiobacillus albertensis (DSM 14366)

open access: yesStandards in Genomic Sciences, 2017
Acidithiobacillus albertensis is an extremely acidophilic, mesophilic, obligatory autotrophic sulfur-oxidizer, with potential importance in the bioleaching of sulfidic metal ores, first described in the 1980s. Here we present the draft genome sequence of
Matías Castro   +11 more
doaj   +1 more source

Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

open access: yesBiological Research, 2021
Background The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, apoptosis and invasiveness ...
Nicole Farfán   +4 more
doaj   +1 more source

Evaluation of the safety and satisfaction of rheumatic patients with accelerated infliximab infusion

open access: yesAdvances in Rheumatology, 2018
Introduction Infliximab infusion generally occurs in 2–4 h. Recent studies have suggested the possibility of accelerated infusion (1 h) of this drug. Objective To evaluate the safety of accelerated infliximab infusion in patients with rheumatic diseases.
Jozélio Freire de Carvalho   +5 more
doaj   +1 more source

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