Results 41 to 50 of about 5,053,828 (347)

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Multifunctional Protein Eutectogels Based on Polyphenolic: Zwitterionic Low‐Transition‐Temperature Mixtures

Advanced Functional Materials, EarlyView.
This work presents the first example of multifunctional protein eutectogels based on a tannic acid: betaine low‐transition‐temperature mixture, exhibiting elastomeric behavior, strong adhesion to various substrates, including biological tissues, and notable anti‐inflammatory properties derived from the natural polyphenol and zwitterion.
Sergio Martin‐Saldaña, Alberto de León, María de la Mata, Nikolaos Politakos, Jorge L. Olmedo‐Martínez, Alejandro J. Müller, Ana Beloqui, Marcelo Calderón, Matias L. Picchio   +8 more
wiley   +1 more source

Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Nature Communications, 2019
Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and ...
Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser   +10 more
doaj   +1 more source

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

Frontiers in Aging Neuroscience, 2012
Protein folding occurs in several intracellular locations including the endoplasmic reticulum (ER) and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery.
Sebastián eBernales, Marisol Andrea Morales Soto, Marisol Andrea Morales Soto, Emma eMcCullagh   +3 more
doaj   +1 more source

Aprender a vivir. Existencia, pensamiento, huella en/de Derrida.

Pensamiento. Revista de Investigación e Información Filosófica, 2020
En este trabajo abordo el problema de la herencia nietzscheana en el pensamiento de Jacques Derrida como base para plantear la cuestión de la huella de éste último en la filosofía actual.
Domingo Fernández Agis
doaj   +1 more source

Sequential Tumor Microenvironment Reprogramming by Nanoplatform Potentiates Sonodynamic‐Chemodynamic Therapy and Immune Checkpoint Blockade in Breast Cancer

Advanced Science, EarlyView.
A modular nanoplatform capable of sequentially reprogramming tumor microenvironment via cascade actions and responsive therapeutic functions is reported for breast cancer therapy. Via a dual‐targeting mechanism and responsive PD‐L1 antibody release, this nanoplatform enables amplified sonodynamic‐chemodynamic therapy and elicits robust immune response ...
Yang Yu, Zheming Song, Anni Zhu, Jingchao Li, Rujia Fan, Bing Xiao   +5 more
wiley   +1 more source

La vida como proyecto y sentido

Pensamiento. Revista de Investigación e Información Filosófica, 2020
El propósito de este artículo es aproximarnos al tratamiento que la cuestión del sentido antropológico ha recibido por parte de dos egregios filósofos españoles.
Guillem Turró-Ortega, Miquel Seguró-Mendlewicz   +1 more
doaj   +1 more source

Rhinebeck Central School District and Rhinebeck Teachers Association, New York State United of Teachers (NYSUT), American Federation of Teachers (AFT), AFL-CIO (2011) [PDF]

, 2011
Recent trends in transport and communication infrastructures have had a profound impact on the tourism industry. Despite the growing number and importance of online travel agencies and travel metasearch sites tourism literature addressing this issue is ...
Boros, Lajos, Dudás, Gábor, Vida, György   +2 more
core   +2 more sources

Using community‐based participatory research to contextualize Latino exposure to community violence: A mixed qualitative and spatial analysis approach

American Journal of Community Psychology, EarlyView.
Abstract While the relationship between community violence exposure and maladaptive outcomes has been established, the dynamic between violence exposure and resilience factors in youth is not well understood. The current study utilizes a community‐based participatory research (CBPR) framework and employs a novel mixed‐methods approach integrating ...
Kyle C. Deane, Maureen T. S. Burns, Maryse H. Richards, Catherine DeCarlo Santiago, Ogechi “Cynthia” Onyeka, Amanda White, Felix K. So   +6 more
wiley   +1 more source